results 445-456 of 704
EON’s DINI (Diet-Infection-Nutrition-Immunity) Axis approach – Proof of Concept: Immunomodulatory Nutritional Intervention for CRC Management
19/04/2021
Inventors: Kumar Pranav Narayan
The study investigates EON’s DINI (Diet-Infection-Nutrition-Immunity) Axis approach as a proof of concept for managing colorectal cancer (CRC). This approach integrates dietary strategies, infection control, nutritional support, and immune system modulation to enhance CRC management. The research explores how specific nutritional interventions can influence immune responses and microbial environments to...
The study investigates EON’s DINI (Diet-Infection-Nutrition-Immunity) Axis approach as a proof of concept for managing colorectal cancer (CRC). This approach integrates dietary strategies, infection control, nutritional support, and immune system modulation to enhance CRC management. The research explores how specific nutritional interventions can influence immune responses and microbial environments to improve patient outcomes. By examining the effectiveness of this holistic approach, the study aims to demonstrate the potential of immunomodulatory nutritional strategies in supporting CRC treatment and management, potentially offering a complementary method to traditional therapies. (Biological Science)
Second Messenger (p)ppGpp Mediated Bacterial Persistence and Regulation of SpoT”
30/03/2021
Inventors: Kirtimaan Syal
The study explores the role of the second messenger (p)ppGpp in bacterial persistence and its regulation of the SpoT protein. (p)ppGpp is a key signaling molecule involved in bacterial stress responses and survival strategies, particularly under adverse conditions. The research investigates how (p)ppGpp contributes to bacterial persistence by modulating metabolic...
The study explores the role of the second messenger (p)ppGpp in bacterial persistence and its regulation of the SpoT protein. (p)ppGpp is a key signaling molecule involved in bacterial stress responses and survival strategies, particularly under adverse conditions. The research investigates how (p)ppGpp contributes to bacterial persistence by modulating metabolic processes and stress responses. Additionally, the study examines how SpoT, an enzyme that synthesizes and degrades (p)ppGpp, regulates its levels and influences bacterial adaptation. Understanding these mechanisms could provide insights into bacterial resistance and persistence, offering potential targets for novel antimicrobial strategies. (Biological Science)
Design and Simulation of Improved Polysaccharide based Membranes, the Future Must for Food Packaging
07/07/2022
Inventors: Durba Roy
The study focuses on designing and simulating enhanced polysaccharide-based membranes for food packaging applications. These membranes leverage natural polysaccharides to create sustainable, biodegradable, and functional packaging materials. The research involves optimizing membrane properties such as strength, permeability, and resistance to moisture and gases through computational simulations. The aim is to...
The study focuses on designing and simulating enhanced polysaccharide-based membranes for food packaging applications. These membranes leverage natural polysaccharides to create sustainable, biodegradable, and functional packaging materials. The research involves optimizing membrane properties such as strength, permeability, and resistance to moisture and gases through computational simulations. The aim is to improve the performance of these membranes in preserving food quality and extending shelf life, while also addressing environmental concerns associated with traditional packaging materials. By advancing polysaccharide-based membranes, the study seeks to contribute to more sustainable and effective food packaging solutions for the future. (Chemistry)
Synthesis of Novel Coumarin-Based Lignans Targeting Pro-Inflammatory Cytokines for the Treatment of Chronic Kidney Disease
29/01/2021
Inventors: Sajeli Begum
The study focuses on synthesizing novel coumarin-based lignans designed to target pro-inflammatory cytokines for treating chronic kidney disease (CKD). Coumarin-based lignans are compounds with potential anti-inflammatory properties. The research involves developing these novel lignans to specifically inhibit cytokines that contribute to inflammation and progression of CKD. By targeting these inflammatory...
The study focuses on synthesizing novel coumarin-based lignans designed to target pro-inflammatory cytokines for treating chronic kidney disease (CKD). Coumarin-based lignans are compounds with potential anti-inflammatory properties. The research involves developing these novel lignans to specifically inhibit cytokines that contribute to inflammation and progression of CKD. By targeting these inflammatory mediators, the goal is to reduce kidney inflammation, slow disease progression, and offer new therapeutic options for CKD patients. The study aims to advance treatment strategies by creating compounds that address underlying inflammation in CKD effectively. (Pharmacy)
Designing Metallo(Salen) Polymers for Detection of Phosphorylated Peptides and Proteins: Amplification of Signal via Disassembly Strategy
13/09/2022
Inventors: Nilanjan Dey
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The study focuses on designing metallo(salen) polymers to detect phosphorylated peptides and proteins, utilizing an amplification strategy through polymer disassembly. Metallo(salen) polymers are advanced materials that incorporate metal complexes within a salen ligand framework, providing enhanced selectivity and sensitivity for biochemical detection. The research involves developing these polymers to specifically...
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The study focuses on designing metallo(salen) polymers to detect phosphorylated peptides and proteins, utilizing an amplification strategy through polymer disassembly. Metallo(salen) polymers are advanced materials that incorporate metal complexes within a salen ligand framework, providing enhanced selectivity and sensitivity for biochemical detection. The research involves developing these polymers to specifically bind phosphorylated targets, and then employing a disassembly strategy to amplify the detection signal. This approach aims to improve the accuracy and sensitivity of assays for phosphorylated biomolecules, which are critical in various biological processes and disease states, thereby advancing diagnostic and research applications. (Chemistry)
Implementation of Ionic Liquids in Crystallization Protocol: Applications in Crystal Engineering
13/09/2022
Inventors: Arijit Mukherjee
The study investigates the use of ionic liquids in crystallization protocols to enhance crystal engineering processes. Ionic liquids, with their unique properties, offer advantages such as improved solubility control, stabilization of diverse crystal forms, and tailored nucleation and growth dynamics. The research explores how these characteristics can be leveraged to...
The study investigates the use of ionic liquids in crystallization protocols to enhance crystal engineering processes. Ionic liquids, with their unique properties, offer advantages such as improved solubility control, stabilization of diverse crystal forms, and tailored nucleation and growth dynamics. The research explores how these characteristics can be leveraged to refine crystallization methods, leading to higher purity, better yield, and more precise control over crystal morphology. Applications include designing novel materials and optimizing the formation of specific crystal structures, which can advance fields like pharmaceuticals and materials science by enabling the production of high-quality, functionally tailored crystals (Chemistry)
Dynamics of Active Particles Near a Non-Isothermal Fluid-Fluid Interface
13/07/2021
Inventors: Sayan Das
The study explores the behavior of active particles—particles that can self-propel or exhibit dynamic activity—near a non-isothermal fluid-fluid interface. In this context, ""non-isothermal"" refers to interfaces where there is a temperature gradient between two immiscible fluids. The research examines how these temperature variations influence the motion, interactions, and distribution of...
The study explores the behavior of active particles—particles that can self-propel or exhibit dynamic activity—near a non-isothermal fluid-fluid interface. In this context, ""non-isothermal"" refers to interfaces where there is a temperature gradient between two immiscible fluids. The research examines how these temperature variations influence the motion, interactions, and distribution of active particles at the interface. By modeling these dynamics, the study aims to understand phenomena such as particle drift, aggregation, and dispersion, which can have implications for applications in material science, microfluidics, and chemical engineering. (Mechanical Engineering)
Development of the Ti6Al4V Alloy Structure using Wire Arc Additive Manufacturing Process for Aerospace Application
01/02/2022
Inventors: Ravi Shanker Vidyarthy
The study focuses on developing Ti6Al4V alloy structures using the wire arc additive manufacturing (WAAM) process for aerospace applications. Ti6Al4V is a high-strength titanium alloy known for its excellent mechanical properties and corrosion resistance, making it ideal for aerospace components. The research involves optimizing WAAM parameters to enhance the quality...
The study focuses on developing Ti6Al4V alloy structures using the wire arc additive manufacturing (WAAM) process for aerospace applications. Ti6Al4V is a high-strength titanium alloy known for its excellent mechanical properties and corrosion resistance, making it ideal for aerospace components. The research involves optimizing WAAM parameters to enhance the quality and performance of Ti6Al4V structures, including factors such as deposition rate, temperature control, and material integrity. The goal is to improve the efficiency and cost-effectiveness of producing complex aerospace parts, while ensuring they meet stringent performance and safety standards. (Mechanical Engineering)
Calpain Mediated Disruption of Axon-Glia Interaction in Peripheral Neuropathies
Development And Characterisation ofrLS Polymerase Zeta Subunit MAD2B/Rev7 Targeted Inhibitors As Potential Anticancer Therapeutic Agents Using In-Vitro And In-Vivo Approach
01/11/2021
Inventors: Arti Dhar
The study focuses on developing and characterizing inhibitors targeting the polymerase zeta subunit MAD2B/Rev7 as potential anticancer therapeutic agents. Polymerase zeta, involved in DNA damage tolerance, is a key player in cancer cell resistance to treatment. The research involves designing small molecules or compounds that specifically inhibit MAD2B/Rev7, and evaluating...
The study focuses on developing and characterizing inhibitors targeting the polymerase zeta subunit MAD2B/Rev7 as potential anticancer therapeutic agents. Polymerase zeta, involved in DNA damage tolerance, is a key player in cancer cell resistance to treatment. The research involves designing small molecules or compounds that specifically inhibit MAD2B/Rev7, and evaluating their efficacy through in-vitro (laboratory) and in-vivo (animal) models. By targeting this subunit, the study aims to disrupt cancer cell repair mechanisms, enhance the effectiveness of existing therapies, and offer new treatment options for various cancers. (Pharmacy)
Modeling the Effect of Changing Bio Film Thickness on the Performance of a Microbial Fuel Cell
22/12/2021
Inventors: Balaji Krishnamurthy
The study models how variations in biofilm thickness impact the performance of microbial fuel cells (MFCs). Biofilms, which are layers of microorganisms that form on the electrode surfaces, play a crucial role in MFC efficiency. The research involves creating simulations or experimental setups to analyze how changes in biofilm thickness...
The study models how variations in biofilm thickness impact the performance of microbial fuel cells (MFCs). Biofilms, which are layers of microorganisms that form on the electrode surfaces, play a crucial role in MFC efficiency. The research involves creating simulations or experimental setups to analyze how changes in biofilm thickness affect key performance metrics such as power output, current density, and overall energy conversion. By understanding these effects, the study aims to optimize biofilm characteristics for enhanced MFC performance, contributing to more effective and sustainable bioenergy solutions. (Chemical Engineering)
Prediction of RUL (Remaining Useful Life) of the Lithium-Ion Battery Pack using Machine Learning Techniques for Second Life Usage
14/07/2022
Inventors: Alivelu Manga Parimi, Parikshit Sahatiya, Ankur Bhattacharjee
The study focuses on predicting the Remaining Useful Life (RUL) of lithium-ion battery packs using machine learning techniques, specifically for their second-life applications. This involves developing algorithms that analyze data from battery usage, degradation patterns, and performance metrics to estimate how much longer the batteries will remain functional. The goal...
The study focuses on predicting the Remaining Useful Life (RUL) of lithium-ion battery packs using machine learning techniques, specifically for their second-life applications. This involves developing algorithms that analyze data from battery usage, degradation patterns, and performance metrics to estimate how much longer the batteries will remain functional. The goal is to extend the batteries' usability by accurately forecasting their remaining life, enabling their repurposing for applications such as energy storage or less demanding tasks. The research aims to enhance the lifecycle management of lithium-ion batteries, reduce waste, and promote sustainable practices in energy storage. (EEE)
