results 421-432 of 704
Tailor-made, Tumor-Targeted Vitaprotein Nanoparticles of Lapatinib and Letrozole as NanoChemo-Cocktail for Hormone-Receptor-Amplified Advanced Metastatic Breast Cancers Treatment
09/01/2023
Inventors: Swati Biswas, Balaram Ghosh
The study develops tailor-made, tumor-targeted vitaprotein nanoparticles designed to deliver a combination of lapatinib and letrozole for treating hormone-receptor-amplified advanced metastatic breast cancers. Vitaprotein nanoparticles are engineered to target tumor cells specifically, enhancing the delivery of therapeutic agents directly to cancer sites. Lapatinib, a tyrosine kinase inhibitor, and letrozole, an...
The study develops tailor-made, tumor-targeted vitaprotein nanoparticles designed to deliver a combination of lapatinib and letrozole for treating hormone-receptor-amplified advanced metastatic breast cancers. Vitaprotein nanoparticles are engineered to target tumor cells specifically, enhancing the delivery of therapeutic agents directly to cancer sites. Lapatinib, a tyrosine kinase inhibitor, and letrozole, an aromatase inhibitor, are used together to tackle both hormone receptor-positive and HER2-positive breast cancer cells. The goal is to create a nano-chemo-cocktail that improves drug efficacy, minimizes side effects, and offers a more effective treatment strategy for advanced metastatic breast cancer. (Pharmacy)
Synthesis of Transition Metal-Phosphate-Based Nanocomposites and Investigation of their Applications towards Thermal Energy Storage, Thermal Management and Solar Thermal Energy Storage
01/11/2022
Inventors: Sandip S Deshmukh, Rudrarapu Aravind
The study focuses on synthesizing transition metal-phosphate-based nanocomposites and evaluating their applications in thermal energy storage, thermal management, and solar thermal energy storage. Transition metal-phosphate nanocomposites are engineered materials with potentially high thermal stability and energy storage capacity. The research involves:
Synthesis: Developing methods to create these nanocomposites with controlled properties.
Characterization:...
The study focuses on synthesizing transition metal-phosphate-based nanocomposites and evaluating their applications in thermal energy storage, thermal management, and solar thermal energy storage. Transition metal-phosphate nanocomposites are engineered materials with potentially high thermal stability and energy storage capacity. The research involves:
Synthesis: Developing methods to create these nanocomposites with controlled properties.
Characterization: Analyzing their structural, thermal, and performance characteristics.
Applications: Investigating how these materials can be utilized in thermal energy storage systems, thermal management solutions, and solar thermal energy storage, aiming to improve efficiency and effectiveness in managing and storing thermal energy.
The goal is to advance the development of high-performance materials for energy storage and management technologies. (Mechanical Engineering)
Systematic Evaluation of the Role of IRE1 in the Modulation of Chronological Aging via ER -Mitochondrial Crosstalk during Chronic ER Stress
14/10/2022
Inventors: Shuvadeep Maity
The study systematically evaluates the role of IRE1 in regulating chronological aging through its influence on ER-mitochondrial crosstalk during chronic endoplasmic reticulum (ER) stress. IRE1 is a key component of the unfolded protein response (UPR) pathway, which manages cellular stress. The research investigates how IRE1 affects interactions between the ER...
The study systematically evaluates the role of IRE1 in regulating chronological aging through its influence on ER-mitochondrial crosstalk during chronic endoplasmic reticulum (ER) stress. IRE1 is a key component of the unfolded protein response (UPR) pathway, which manages cellular stress. The research investigates how IRE1 affects interactions between the ER and mitochondria, crucial for maintaining cellular homeostasis and aging. By examining these mechanisms under chronic ER stress conditions, the study aims to uncover how IRE1-mediated signaling influences aging processes and cellular longevity, potentially identifying new targets for interventions in age-related diseases and stress-related cellular dysfunctions. (Biological Science)
Antibacterial, Host-Modulating and Regenerative Nanofibers Membrane for Guided Tissue Regeneration
22/11/2022
Inventors: Kumar Pranav Narayan, Jyotsendu Giri and Piyush Khandelia
The study develops a multifunctional nanofiber membrane for guided tissue regeneration, integrating antibacterial, host-modulating, and regenerative properties. The membrane aims to:
Antibacterial: Prevent infections at the regeneration site by incorporating antibacterial agents within the nanofibers.
Host-Modulating: Enhance the natural healing process by positively interacting with host tissue, promoting better integration and repair.
Regenerative:...
The study develops a multifunctional nanofiber membrane for guided tissue regeneration, integrating antibacterial, host-modulating, and regenerative properties. The membrane aims to:
Antibacterial: Prevent infections at the regeneration site by incorporating antibacterial agents within the nanofibers.
Host-Modulating: Enhance the natural healing process by positively interacting with host tissue, promoting better integration and repair.
Regenerative: Support tissue growth and repair through a scaffold that encourages cell adhesion, proliferation, and tissue formation.
This approach seeks to improve guided tissue regeneration outcomes by providing a comprehensive solution for infection control, tissue integration, and regeneration. (Biological Science)
Glucocorticoid Receptor (GR)-Targeted Liposomal Nano-Platform for Drug Sensitization, EMT-Reversal toward Effective Treatment of Aggressive Oral Cancer
18/11/2022
Inventors: Kumar Pranav Narayan, Rajkumar Banerjee
The study investigates a glucocorticoid receptor (GR)-targeted liposomal nano-platform designed to enhance drug sensitivity and reverse epithelial-to-mesenchymal transition (EMT) in aggressive oral cancer. The nano-platform uses liposomes—small lipid-based carriers—to deliver therapeutic agents specifically to cells expressing GR, a receptor often involved in cancer progression and drug resistance. By targeting GR,...
The study investigates a glucocorticoid receptor (GR)-targeted liposomal nano-platform designed to enhance drug sensitivity and reverse epithelial-to-mesenchymal transition (EMT) in aggressive oral cancer. The nano-platform uses liposomes—small lipid-based carriers—to deliver therapeutic agents specifically to cells expressing GR, a receptor often involved in cancer progression and drug resistance. By targeting GR, the platform aims to improve the effectiveness of existing treatments, reverse EMT (which contributes to cancer metastasis), and overcome drug resistance. The goal is to develop a more effective strategy for managing aggressive oral cancer, potentially leading to better patient outcomes and treatment options. (Biological Science)
Allele Mining for the Epigenetic RegulatorNGRS and other Yield-Associated Gene (GRF4) and their Modulation using MultipleGenomic and Molecular Approaches to Enhance Rice Yield under Low Nitrogen Conditions
05/07/2022
Inventors: Gireesha T M, Sridev Mohapatra
The study focuses on allele mining for the epigenetic regulator NGRS and the yield-associated gene GRF4, aiming to enhance rice yield under low nitrogen conditions. Allele mining involves identifying and characterizing genetic variations that affect these genes. The research employs multiple genomic and molecular approaches to understand how different alleles...
The study focuses on allele mining for the epigenetic regulator NGRS and the yield-associated gene GRF4, aiming to enhance rice yield under low nitrogen conditions. Allele mining involves identifying and characterizing genetic variations that affect these genes. The research employs multiple genomic and molecular approaches to understand how different alleles of NGRS and GRF4 influence rice growth and yield when nitrogen is limited. By modulating these genes through genetic engineering or breeding, the goal is to develop rice varieties with improved yield and resilience in low-nitrogen environments, thereby contributing to more sustainable and efficient agricultural practices. (Biological Science)
Lattice Boltzmann Method (LBM)for Multiphase Flow and Transport in Porous Media
26/12/2022
Inventors: Vikranth Kumar Surasani
The study explores the use of the Lattice Boltzmann Method (LBM) for simulating multiphase flow and transport processes in porous media. LBM is a numerical technique based on lattice gas automata that models fluid dynamics and particle interactions on a discrete lattice. The research focuses on applying LBM to capture...
The study explores the use of the Lattice Boltzmann Method (LBM) for simulating multiphase flow and transport processes in porous media. LBM is a numerical technique based on lattice gas automata that models fluid dynamics and particle interactions on a discrete lattice. The research focuses on applying LBM to capture complex interactions between different fluid phases and their movement through porous structures, which is crucial for applications such as groundwater flow, oil recovery, and chemical reactions in porous media. The goal is to enhance the accuracy and efficiency of simulations, providing valuable insights into the behavior and optimization of multiphase flow systems. (Chemical Engineering)
Development of a Meta-Material based Vibration Isolation Frame for Housing Fuel Bundles
23/01/2020
Inventors: Sabareesh Geetha Rajasekharan
The study focuses on developing a meta-material-based vibration isolation frame designed to protect fuel bundles from vibrations. Meta-materials are engineered materials with properties not found in nature, which can be tailored to control vibrations and reduce their transmission. The research involves designing and constructing a frame that incorporates these meta-materials...
The study focuses on developing a meta-material-based vibration isolation frame designed to protect fuel bundles from vibrations. Meta-materials are engineered materials with properties not found in nature, which can be tailored to control vibrations and reduce their transmission. The research involves designing and constructing a frame that incorporates these meta-materials to effectively isolate and absorb vibrations, ensuring the stability and safety of fuel bundles used in various applications, such as energy production or storage. The goal is to enhance the performance and longevity of the equipment by mitigating the effects of vibrations through innovative material design. (Mechanical Engineering)
In-Situ Wittig-Homer Reactions in Dioxygen: Direct And Facile AccessTo Versatile Vinylene-Linked Small And Polymeric X-Conjugates As Potential Molecular Materials
19/12/2022
Inventors: Manab Chakravarty
The study investigates in situ Wittig-Homer reactions in the presence of dioxygen to create vinylene-linked small and polymeric conjugates. Wittig-Homer reactions are used to form vinylene groups, which are crucial for developing conjugated materials. By performing these reactions directly and efficiently with dioxygen, the research aims to simplify the synthesis...
The study investigates in situ Wittig-Homer reactions in the presence of dioxygen to create vinylene-linked small and polymeric conjugates. Wittig-Homer reactions are used to form vinylene groups, which are crucial for developing conjugated materials. By performing these reactions directly and efficiently with dioxygen, the research aims to simplify the synthesis of versatile x-conjugates, which are materials with extensive π-conjugation that can have various applications in molecular electronics and materials science. The approach seeks to provide a straightforward method for accessing these conjugated structures, potentially advancing the development of functional molecular materials with novel electronic properties. (Chemistry)
Design and Simulation of a 325 MHz, 100 kW and 150 kW Inductive Output Tube (IOT)
30/11/2022
Inventors: Harish Dixit
The study involves the design and simulation of a 325 MHz inductive output tube (IOT) with power levels of 100 kW and 150 kW. IOTs are high-power vacuum tubes used in applications such as broadcast transmitters and particle accelerators. The research focuses on developing detailed models to optimize the IOT's...
The study involves the design and simulation of a 325 MHz inductive output tube (IOT) with power levels of 100 kW and 150 kW. IOTs are high-power vacuum tubes used in applications such as broadcast transmitters and particle accelerators. The research focuses on developing detailed models to optimize the IOT's performance at 325 MHz, ensuring efficient operation and power output. Simulations are used to refine the design parameters, including the tube’s geometry, magnetic fields, and electrical characteristics, to achieve the desired power levels while maintaining stability and reliability. The goal is to enhance the IOT's efficiency and performance for advanced technological applications. (EEE)
Single step’ Conversion of CO₂ from Thermal Power Plant Exhaust to Dimethyl Ether
19/12/2022
Inventors: Sounak Roy
The study focuses on a single-step process for converting carbon dioxide (CO₂) from thermal power plant exhaust into dimethyl ether (DME). DME is a valuable chemical and potential clean fuel. The research involves developing a catalytic process that efficiently transforms CO₂, a greenhouse gas, into DME in one step, aiming...
The study focuses on a single-step process for converting carbon dioxide (CO₂) from thermal power plant exhaust into dimethyl ether (DME). DME is a valuable chemical and potential clean fuel. The research involves developing a catalytic process that efficiently transforms CO₂, a greenhouse gas, into DME in one step, aiming to simplify the conversion process compared to traditional multi-step methods. This approach seeks to reduce the carbon footprint of power plants by utilizing CO₂ emissions and producing a useful product, thus contributing to sustainable energy practices and carbon management. The study includes designing the catalyst, optimizing reaction conditions, and evaluating process efficiency (Chemistry)
Design and Synthesis of Microporous Adsorbents for Gas/Vapour Separation and CO₂ Capture
19/12/2022
Inventors: Himanshu Aggarwal
The study focuses on the design and synthesis of microporous adsorbents tailored for gas and vapor separation, with a specific emphasis on carbon dioxide (CO₂) capture. Microporous adsorbents are materials with tiny pores that can selectively adsorb gases and vapors. The research involves creating new adsorbent materials with optimal pore...
The study focuses on the design and synthesis of microporous adsorbents tailored for gas and vapor separation, with a specific emphasis on carbon dioxide (CO₂) capture. Microporous adsorbents are materials with tiny pores that can selectively adsorb gases and vapors. The research involves creating new adsorbent materials with optimal pore structures and chemical properties to enhance their efficiency in separating target gases and capturing CO₂ from industrial emissions or the atmosphere. The study includes developing synthesis methods, characterizing the materials' properties, and evaluating their performance in real-world separation and capture applications, aiming to improve environmental management and sustainability. (Chemistry)
