results 373-384 of 704
Development of a Novel POC Diagnostic Device
29/11/2023
Inventors: Sanket Goel
This paper focuses on the development of a novel point-of-care (POC) diagnostic device. The device is designed to provide rapid, accurate, and reliable diagnostic results in various healthcare settings. The study covers the device’s design and engineering, including the integration of advanced sensors, sample processing mechanisms, and data analysis tools....
This paper focuses on the development of a novel point-of-care (POC) diagnostic device. The device is designed to provide rapid, accurate, and reliable diagnostic results in various healthcare settings. The study covers the device’s design and engineering, including the integration of advanced sensors, sample processing mechanisms, and data analysis tools. It emphasizes the device’s potential to improve patient outcomes by enabling timely diagnosis and management of diseases. The research also evaluates the device's performance through testing and validation to ensure its effectiveness and reliability in real-world applications. (EEE)
The Neuroprotective Effect of Vitamin D3 Involves a Phosphatidyl-Inositol-3 Kinase Pathway Activation to Enhance Alpha7 Nicotinic Acetylcholine Receptor Function in Schizophrenia
09/11/2023
Inventors: Pragya Komal
This paper investigates the neuroprotective effects of Vitamin D3 and its involvement in enhancing alpha7 nicotinic acetylcholine receptor (α7 nAChR) function in schizophrenia. The study explores how Vitamin D3 activates the phosphatidyl-inositol-3 kinase (PI3K) pathway, which is crucial for neuroprotection and cognitive function. By examining the interaction between Vitamin D3,...
This paper investigates the neuroprotective effects of Vitamin D3 and its involvement in enhancing alpha7 nicotinic acetylcholine receptor (α7 nAChR) function in schizophrenia. The study explores how Vitamin D3 activates the phosphatidyl-inositol-3 kinase (PI3K) pathway, which is crucial for neuroprotection and cognitive function. By examining the interaction between Vitamin D3, the PI3K pathway, and α7 nAChR, the research aims to elucidate mechanisms through which Vitamin D3 may offer therapeutic benefits in schizophrenia, potentially improving symptoms and cognitive deficits associated with the disorder. (Biological Science)
Uncertainty Principles in Generalized Function Spaces: Theory and Applications
10/10/2023
Inventors: Manish Kumar
This paper explores uncertainty principles in generalized function spaces, focusing on both theoretical aspects and practical applications. Uncertainty principles typically describe the trade-off between the precision of a function's representation in time and frequency domains. The study extends these principles to generalized function spaces, which encompass a broader range of...
This paper explores uncertainty principles in generalized function spaces, focusing on both theoretical aspects and practical applications. Uncertainty principles typically describe the trade-off between the precision of a function's representation in time and frequency domains. The study extends these principles to generalized function spaces, which encompass a broader range of mathematical functions and distributions. It examines the theoretical foundations of these principles, including their mathematical proofs and implications. The paper also discusses practical applications in areas such as signal processing, quantum mechanics, and applied mathematics, where understanding uncertainty is crucial for accurate modeling and analysis. (Mathematics)
A Multi-Physics Phase Field Framework for Modeling Hydraulic Fracture
05/10/2023
Inventors: Raghu Piska
This paper introduces a multi-physics phase field framework for modeling hydraulic fractures. It integrates various physical phenomena, such as fluid dynamics, solid mechanics, and phase transitions, into a unified phase field model to accurately simulate the behavior of hydraulic fractures in porous media. The study addresses the complexities of fracture...
This paper introduces a multi-physics phase field framework for modeling hydraulic fractures. It integrates various physical phenomena, such as fluid dynamics, solid mechanics, and phase transitions, into a unified phase field model to accurately simulate the behavior of hydraulic fractures in porous media. The study addresses the complexities of fracture initiation, propagation, and interaction with the surrounding material and fluids. By employing this comprehensive framework, the research aims to improve the understanding and prediction of hydraulic fracture processes, which are crucial for applications like hydraulic fracturing in energy extraction and subsurface engineering. (Civil Engineering)
Development of Intelligent System for Sustainable Micromanufacturing of Microneedle Arrays of Difficult-to-cut Materials with an Application to Biofabrication
03/10/2023
Inventors: Kundan Singh, Brajesh Panigrahi and NSK Reddy
This paper focuses on developing an intelligent system for the sustainable micromanufacturing of microneedle arrays made from difficult-to-cut materials, with applications in biofabrication. The study involves designing a system that can efficiently handle and process challenging materials used in creating microneedles, which are essential for medical and biotechnology applications. It...
This paper focuses on developing an intelligent system for the sustainable micromanufacturing of microneedle arrays made from difficult-to-cut materials, with applications in biofabrication. The study involves designing a system that can efficiently handle and process challenging materials used in creating microneedles, which are essential for medical and biotechnology applications. It covers advancements in manufacturing technology, including automated precision machining and real-time process control. The goal is to enhance the production efficiency, sustainability, and quality of microneedle arrays, facilitating their use in various biofabrication processes and improving their performance in medical applications. (Mechanical Engineering)
Development of covalent organic framework-based Vis-to NIR electrochromic smart windows for solar heat modulation
03/10/2023
Inventors: Chanchal Chakraborty
This paper discusses the development of covalent organic framework (COF)-based electrochromic smart windows designed for solar heat modulation. The study focuses on creating COF materials that exhibit color changes from visible to near-infrared (NIR) regions when subjected to an electric field. These smart windows can modulate solar heat gain by...
This paper discusses the development of covalent organic framework (COF)-based electrochromic smart windows designed for solar heat modulation. The study focuses on creating COF materials that exhibit color changes from visible to near-infrared (NIR) regions when subjected to an electric field. These smart windows can modulate solar heat gain by adjusting their optical properties in response to applied voltages, thereby improving energy efficiency in buildings. The research covers the synthesis of COF materials, their electrochromic properties, and their performance in regulating solar heat, aiming to enhance building climate control and reduce energy consumption. (Chemistry)
Pharmacological Evaluation and Characterization of a Novel SARM1 Inhibitor in the Preclinical Model of Charcot-Marie-Tooth 2A (CMT2A)
27/09/2023
Inventors: Abhijieet Rajendra Joshi, D Sriram and Punna Rao Ravi
This paper presents the pharmacological evaluation and characterization of a novel SARM1 inhibitor in a preclinical model of Charcot-Marie-Tooth 2A (CMT2A), a genetic neuropathy. SARM1 (Sterile Alpha and Toll/Interleukin-1 receptor motif-containing protein 1) is implicated in neuronal degeneration and axonal loss, making it a target for therapeutic intervention. The study...
This paper presents the pharmacological evaluation and characterization of a novel SARM1 inhibitor in a preclinical model of Charcot-Marie-Tooth 2A (CMT2A), a genetic neuropathy. SARM1 (Sterile Alpha and Toll/Interleukin-1 receptor motif-containing protein 1) is implicated in neuronal degeneration and axonal loss, making it a target for therapeutic intervention. The study includes the synthesis and administration of the SARM1 inhibitor, assessing its efficacy in slowing or reversing disease progression in animal models of CMT2A. Key aspects include the evaluation of the inhibitor's pharmacokinetics, safety profile, and impact on disease-related biomarkers and symptoms, aiming to advance potential treatments for this hereditary neuropathy. (Pharmacy)
Design, Synthesis and Evaluation of Novel Thiochromene Analogs as Potential Anti-Leishmanial Agents
19/09/2023
Inventors: Dr Murugesn S, KVG Chana Sekhar
This paper details the design, synthesis, and evaluation of novel thiochromene analogs as potential anti-leishmanial agents. Thiochromenes are explored for their potential therapeutic properties against leishmaniasis, a parasitic disease caused by protozoa of the genus Leishmania. The study includes the chemical synthesis of various thiochromene derivatives, followed by in vitro...
This paper details the design, synthesis, and evaluation of novel thiochromene analogs as potential anti-leishmanial agents. Thiochromenes are explored for their potential therapeutic properties against leishmaniasis, a parasitic disease caused by protozoa of the genus Leishmania. The study includes the chemical synthesis of various thiochromene derivatives, followed by in vitro biological testing to assess their efficacy against leishmania parasites. The aim is to identify promising candidates with potent anti-leishmanial activity, offering new avenues for drug development and treatment strategies for this neglected tropical disease. (Chemistry)
SMA-Based lock and release Mechanism for Defence Application
05/09/2023
Inventors: Amit Kumar Gupta, Abhishek Sarkar and Pardha Saradhi G V
This paper explores the development of a shape memory alloy (SMA)-based lock and release mechanism designed for defense applications. SMA materials exhibit unique properties of changing shape in response to temperature changes, which can be leveraged to create mechanisms that lock and release securely and reliably. The study covers the...
This paper explores the development of a shape memory alloy (SMA)-based lock and release mechanism designed for defense applications. SMA materials exhibit unique properties of changing shape in response to temperature changes, which can be leveraged to create mechanisms that lock and release securely and reliably. The study covers the design principles, material selection, and operational performance of the SMA-based mechanism. It evaluates its effectiveness in various defense scenarios, aiming to enhance the reliability and functionality of locking systems used in military and security applications. (Mechanical Engineering)
Discovery and Biological Evaluation of Novel Dual Inhibitors of DprE1 and InhA as Potential Anti-Tubercular Agents
29/08/2023
Inventors: KVG Chandra Sekhar, Murugesn S
This paper focuses on the discovery and biological evaluation of novel dual inhibitors targeting both DprE1 and InhA as potential anti-tubercular agents. DprE1 and InhA are key enzymes in the biosynthesis of mycolic acids, essential components of the Mycobacterium tuberculosis cell wall. The study involves identifying new compounds that can...
This paper focuses on the discovery and biological evaluation of novel dual inhibitors targeting both DprE1 and InhA as potential anti-tubercular agents. DprE1 and InhA are key enzymes in the biosynthesis of mycolic acids, essential components of the Mycobacterium tuberculosis cell wall. The study involves identifying new compounds that can inhibit both enzymes simultaneously, assessing their efficacy in inhibiting bacterial growth, and evaluating their potential as therapeutic agents. The goal is to develop more effective treatments for tuberculosis by targeting multiple crucial pathways in the bacteria. (Chemistry)
Therapeutic Potential and Functional Role of RIP-1/RIP-3 Mediated Necroptosis Pathway in the Progression of Oral Squamous Cell Carcinoma
30/08/2023
Inventors: Onkar Prakash Kulkarni
This paper investigates the therapeutic potential and functional role of the RIP-1/RIP-3 mediated necroptosis pathway in the progression of oral squamous cell carcinoma (OSCC). It explores how necroptosis, a programmed form of cell death regulated by RIP-1 and RIP-3 proteins, influences tumor development and progression in OSCC. The study evaluates...
This paper investigates the therapeutic potential and functional role of the RIP-1/RIP-3 mediated necroptosis pathway in the progression of oral squamous cell carcinoma (OSCC). It explores how necroptosis, a programmed form of cell death regulated by RIP-1 and RIP-3 proteins, influences tumor development and progression in OSCC. The study evaluates the impact of modulating this pathway on cancer cell survival, proliferation, and response to treatment. By understanding the role of necroptosis in OSCC, the research aims to identify potential therapeutic targets and strategies for improving treatment outcomes in patients with this type of cancer. (Pharmacy)
English for the EDI generation: Predicting and tracking the role of English and digital/mobile technologies in Higher Education across East and South Asia
27/07/2023
Inventors: Agnes Kukulska-Hulme, Santosh Kumar Mahapatra
This paper explores the role of English and digital/mobile technologies in higher education across East and South Asia, focusing on their influence on equity, diversity, and inclusion (EDI) generation. It aims to predict and track how these factors interact and contribute to educational outcomes. The study examines the impact of...
This paper explores the role of English and digital/mobile technologies in higher education across East and South Asia, focusing on their influence on equity, diversity, and inclusion (EDI) generation. It aims to predict and track how these factors interact and contribute to educational outcomes. The study examines the impact of English proficiency and technological integration on student access, participation, and success in higher education. By analyzing trends and correlations, the research provides insights into how these elements shape educational experiences and opportunities, and offers recommendations for enhancing EDI through language and technology in the region. (Humanities & Social Sciences)
