results 337-348 of 704
To Improve The Efficiency Of Genome Editing With CRISPR-Cas9 And To Create Novel Sources Of Epigenetic Variation In Plants
28/06/2023
Inventors: Gireesha T M, Sridev Mahopatra
This paper aims to improve the efficiency of genome editing using the CRISPR-Cas9 system and to explore novel sources of epigenetic variation in plants. The study focuses on optimizing CRISPR-Cas9 techniques to enhance precision, efficiency, and outcomes of genome editing in plant species. It also investigates how to harness epigenetic...
This paper aims to improve the efficiency of genome editing using the CRISPR-Cas9 system and to explore novel sources of epigenetic variation in plants. The study focuses on optimizing CRISPR-Cas9 techniques to enhance precision, efficiency, and outcomes of genome editing in plant species. It also investigates how to harness epigenetic modifications to introduce new forms of genetic variation that can be used for plant improvement. The research includes developing new CRISPR-Cas9 variants or delivery methods, as well as examining the potential of epigenetic changes for creating beneficial traits in plants. The goal is to advance plant biotechnology by improving genome editing capabilities and expanding the scope of genetic and epigenetic variations available for crop enhancement. (Biological Science)
Human Serum Albumin-Based Nanoparticles As An Anti-Proteasome Therapy For The Treatment Of Advanced Metastatic Triple-Negative Breast Cancer
21/06/2023
Inventors: Swati Biswas, Balaram Ghosh
This paper investigates the use of human serum albumin-based nanoparticles as a therapeutic approach for treating advanced metastatic triple-negative breast cancer (TNBC). Human serum albumin (HSA) nanoparticles are explored for their potential to deliver anti-proteasome agents specifically to cancer cells. The study involves the design and development of these nanoparticles,...
This paper investigates the use of human serum albumin-based nanoparticles as a therapeutic approach for treating advanced metastatic triple-negative breast cancer (TNBC). Human serum albumin (HSA) nanoparticles are explored for their potential to deliver anti-proteasome agents specifically to cancer cells. The study involves the design and development of these nanoparticles, focusing on their ability to target and inhibit proteasome activity in TNBC cells. The research includes evaluating the efficacy of the nanoparticle-based therapy in preclinical models, assessing its impact on tumor growth and metastasis, and determining its safety profile. The goal is to enhance treatment options for TNBC by leveraging targeted nanoparticle delivery systems. (Pharmacy)
Development, Optimization And Evaluation Of Stable Multidose Injectable Formulation Of Anticancer Drug
21/06/2023
Inventors: Akash Chaurasiya
This paper focuses on the development, optimization, and evaluation of a stable multidose injectable formulation for an anticancer drug. The study addresses the challenges of formulating a drug that remains stable over multiple doses and extended storage periods, which is crucial for effective cancer treatment. It involves designing the formulation...
This paper focuses on the development, optimization, and evaluation of a stable multidose injectable formulation for an anticancer drug. The study addresses the challenges of formulating a drug that remains stable over multiple doses and extended storage periods, which is crucial for effective cancer treatment. It involves designing the formulation to ensure chemical stability, efficacy, and safety while optimizing the drug delivery system to maintain its therapeutic properties. The research includes extensive testing to evaluate the stability of the formulation, its performance in delivering the drug, and its overall suitability for clinical use. The aim is to improve the reliability and convenience of administering anticancer treatments. (Pharmacy)
CatCE2: Catalysis for Circular Economy towards Sustainable Energy
21/06/2023
Inventors: Sounak Roy
This paper explores CatCE2, a catalytic approach designed to support the circular economy and advance sustainable energy solutions. The focus is on developing and applying catalytic processes that facilitate the recycling and repurposing of materials, contributing to a more sustainable and resource-efficient economy. The study examines how these catalytic technologies...
This paper explores CatCE2, a catalytic approach designed to support the circular economy and advance sustainable energy solutions. The focus is on developing and applying catalytic processes that facilitate the recycling and repurposing of materials, contributing to a more sustainable and resource-efficient economy. The study examines how these catalytic technologies can transform waste and by-products into valuable energy resources or reusable materials. It includes the design, optimization, and application of catalysts for various circular economy processes, aiming to reduce environmental impact and promote sustainable energy practices. The goal is to integrate catalytic innovations into circular economy frameworks to enhance sustainability and resource efficiency. (Chemistry)
Development of a Wound Dressing Material with a Simultaneous Dual Function of Antibacterial and Visible Colorimetric Detection of Infection
14/06/2023
Inventors: Jayati Ray Dutta, Ramakrishnan Ganesan
This paper discusses the development of a wound dressing material that performs dual functions: providing antibacterial protection and offering visible colorimetric detection of infection. The dressing incorporates antibacterial agents to prevent or reduce bacterial growth, thus promoting wound healing. Simultaneously, it features a colorimetric system that changes color in response...
This paper discusses the development of a wound dressing material that performs dual functions: providing antibacterial protection and offering visible colorimetric detection of infection. The dressing incorporates antibacterial agents to prevent or reduce bacterial growth, thus promoting wound healing. Simultaneously, it features a colorimetric system that changes color in response to infection-related factors, allowing for easy visual detection of infection. The study involves designing and fabricating the dressing, integrating these functionalities, and evaluating its performance in both antibacterial efficacy and infection detection. The goal is to create a multifunctional dressing that enhances wound management by combining effective infection control with real-time monitoring. (Biological Science)
PhysX Based Simulation of the Erection Scheme for a Network Arch Bridge
10/06/2023
Inventors: Amit Kumar Gupta, Pardha Saradhi G V and Abhishek Sarkar
This paper presents a PhysX-based simulation of the erection scheme for a network arch bridge. PhysX is a physics engine used to model complex physical interactions in simulations. The study applies PhysX to simulate the construction process of a network arch bridge, focusing on the dynamic and structural aspects of...
This paper presents a PhysX-based simulation of the erection scheme for a network arch bridge. PhysX is a physics engine used to model complex physical interactions in simulations. The study applies PhysX to simulate the construction process of a network arch bridge, focusing on the dynamic and structural aspects of the erection scheme. It involves modeling the bridge's components, construction sequence, and the interactions between them to predict performance, stability, and potential issues during construction. The goal is to enhance the understanding of bridge erection techniques and improve the design and safety of network arch bridges through detailed, accurate simulations. (Mechanical Engineering)
Early-Universe Physics in Teleparallel Cosmology
05/02/2024
Inventors: Bivudutta Mishra
This paper explores early-universe physics within the framework of teleparallel cosmology. Teleparallel gravity is an alternative theory to general relativity that uses torsion rather than curvature to describe gravitational interactions. The study focuses on applying teleparallel cosmology to understand phenomena in the early universe, such as cosmic inflation, primordial fluctuations,...
This paper explores early-universe physics within the framework of teleparallel cosmology. Teleparallel gravity is an alternative theory to general relativity that uses torsion rather than curvature to describe gravitational interactions. The study focuses on applying teleparallel cosmology to understand phenomena in the early universe, such as cosmic inflation, primordial fluctuations, and the formation of structures. It examines how the teleparallel framework influences cosmological models and compares its predictions with those of general relativity. The goal is to provide insights into the early universe's dynamics and potentially offer new perspectives on cosmological evolution and the fundamental nature of gravity. (Mathematics)
Conjugacy Classes Of Centralizers In Solvable Algebraic Groups
22/01/2024
Inventors: Sushil Bhunia
This paper investigates the conjugacy classes of centralizers in solvable algebraic groups. In the context of algebraic group theory, the centralizer of an element in a group is the set of elements that commute with it, and its conjugacy class is the set of all centralizers related by group conjugation....
This paper investigates the conjugacy classes of centralizers in solvable algebraic groups. In the context of algebraic group theory, the centralizer of an element in a group is the set of elements that commute with it, and its conjugacy class is the set of all centralizers related by group conjugation. The study focuses on characterizing these conjugacy classes within solvable algebraic groups, which are groups that have a series of subgroups where each is normal in the next, and their quotient groups are abelian. The paper explores the structure and properties of these centralizers and their implications for the broader theory of algebraic groups, providing insights into the behavior of solvable groups and their centralizers. (Mathematics)
Physiological and Pharmacological Significance of Formate-Nitrite Type Transporters in Toxoplasma gondii
12/02/2024
Inventors: Nishith Gupta
This paper examines the physiological and pharmacological significance of formate-nitrite type transporters in Toxoplasma gondii. These transporters are involved in the uptake and regulation of formate and nitrite, which are crucial for the parasite's metabolic processes. The study explores how these transporters influence the physiology of T. gondii, including their...
This paper examines the physiological and pharmacological significance of formate-nitrite type transporters in Toxoplasma gondii. These transporters are involved in the uptake and regulation of formate and nitrite, which are crucial for the parasite's metabolic processes. The study explores how these transporters influence the physiology of T. gondii, including their role in growth, survival, and pathogenicity. It also investigates the potential of targeting these transporters with pharmacological agents to develop new treatments for toxoplasmosis. The goal is to understand the transporters' functional roles and their impact on the parasite’s biology, providing insights for therapeutic development. (Biological Science)
A Target Guided Approach for Design, Synthesis, and Screening of Host-Directed Therapies for TB and Associated Metabolic Disorder (PCOS) in Women
14/02/2024
Inventors: Ruchi Jain Dey, KVG Chandra Sekhar and Arnab Banerjee
This paper explores a target-guided approach for the design, synthesis, and screening of host-directed therapies aimed at treating tuberculosis (TB) and associated metabolic disorders such as polycystic ovary syndrome (PCOS) in women. The study focuses on developing therapies that target the host’s cellular mechanisms to enhance treatment efficacy for TB...
This paper explores a target-guided approach for the design, synthesis, and screening of host-directed therapies aimed at treating tuberculosis (TB) and associated metabolic disorders such as polycystic ovary syndrome (PCOS) in women. The study focuses on developing therapies that target the host’s cellular mechanisms to enhance treatment efficacy for TB while simultaneously addressing metabolic disturbances linked to the disease. It involves identifying therapeutic targets, synthesizing potential drug candidates, and screening their effectiveness in preclinical models. The goal is to create integrated treatment strategies that can address both TB and its associated metabolic complications, improving overall health outcomes for affected women. (Biological Science)
Revolutionizing Phototherapy with Hypoxia-Reversing Photothermal/Photodynamic Nanoparticles-Laden In Situ Gel for Non-Invasive Tumor Ablation in Oral Cancer
06/02/2024
Inventors: Swati Biswas, Balaram Ghosh
This paper presents a novel approach to phototherapy for oral cancer using hypoxia-reversing photothermal and photodynamic nanoparticles integrated into an in situ gel. The gel, loaded with nanoparticles, is designed to address the challenge of hypoxia, a common condition in tumors that limits the effectiveness of traditional phototherapy. The study...
This paper presents a novel approach to phototherapy for oral cancer using hypoxia-reversing photothermal and photodynamic nanoparticles integrated into an in situ gel. The gel, loaded with nanoparticles, is designed to address the challenge of hypoxia, a common condition in tumors that limits the effectiveness of traditional phototherapy. The study focuses on the development and characterization of these nanoparticles, their integration into a light-responsive gel, and the mechanism by which they reverse hypoxia to enhance the efficacy of photothermal and photodynamic treatments. The goal is to provide a non-invasive, effective method for tumor ablation, improving treatment outcomes and reducing side effects in oral cancer therapy. (Pharmacy)
Antibacterial Nanozyme – Laden in situ Light Responsive Hydrogel for Tissue Regeneration and Quoru Sensing Inhibition to Revert Antimicrobial Resistance in Diabetic Foot Uleers
02/02/2024
Inventors: Swati Biswas, Balaram Ghosh
This paper discusses the development of an antibacterial nanozyme-loaded, light-responsive hydrogel designed for tissue regeneration and quorum sensing inhibition in diabetic foot ulcers. The hydrogel incorporates nanozymes, which are nanomaterial-based enzymes with antibacterial properties, and responds to light stimuli to enhance its functionality. The study explores how this hydrogel can...
This paper discusses the development of an antibacterial nanozyme-loaded, light-responsive hydrogel designed for tissue regeneration and quorum sensing inhibition in diabetic foot ulcers. The hydrogel incorporates nanozymes, which are nanomaterial-based enzymes with antibacterial properties, and responds to light stimuli to enhance its functionality. The study explores how this hydrogel can promote wound healing and inhibit bacterial quorum sensing, a mechanism that contributes to antimicrobial resistance. By targeting both bacterial infection and resistance mechanisms, the hydrogel aims to improve treatment outcomes for diabetic foot ulcers, facilitating tissue regeneration and reducing the risk of chronic infections. (Pharmacy)
