results 637-648 of 704
Blast Response of Functionally Graded Auxetic Sandwich Structures with Tunable Material Properties
26/09/2023
Inventors: Gaurav Watts
In this study, the research aims to investigate the blast response characteristics of functionally graded auxetic sandwich structures that exhibit tunable material properties. Through detailed analysis and experimentation, the focus will be on determining how the unique combination of auxetic behavior and material gradation influences the structural integrity and energy...
In this study, the research aims to investigate the blast response characteristics of functionally graded auxetic sandwich structures that exhibit tunable material properties. Through detailed analysis and experimentation, the focus will be on determining how the unique combination of auxetic behavior and material gradation influences the structural integrity and energy absorption capabilities of the sandwich structures under blast loading conditions. The objective is to provide insights that can contribute to the development and optimization of advanced protective systems with enhanced blast resistance for various engineering applications. (Mechanical Engineering)
Excited State (Anti)Aromaticity-Guided Charge Transfer Fluorophore Research for Biological Imaging
26/09/2023
Inventors: Avik Kumar Pati
In the realm of research aimed at enhancing biological imaging techniques, a groundbreaking focus has emerged on harnessing the principles of excited state (anti)aromaticity to guide the development of innovative charge transfer fluorophores. This cutting-edge approach not only promises to revolutionize the field of biological imaging but also showcases the...
In the realm of research aimed at enhancing biological imaging techniques, a groundbreaking focus has emerged on harnessing the principles of excited state (anti)aromaticity to guide the development of innovative charge transfer fluorophores. This cutting-edge approach not only promises to revolutionize the field of biological imaging but also showcases the potential for significant advancements in fluorescence-based technologies. By leveraging the unique properties of (anti)aromatic molecules in excited states, researchers are paving the way for a new generation of fluorophores that exhibit enhanced sensitivity and specificity, offering unprecedented opportunities for improving imaging resolution and molecular detection in biological systems. (Chemistry)
Experimental and Numerical Study of Saltwater Intrusion Control Measures under Tidal Influence
26/09/2023
Inventors: Selva Balaji M
In this comprehensive study, both experimental and numerical methods are employed to investigate various strategies aimed at managing saltwater intrusion in coastal areas affected by tidal forces. The research focuses on analyzing the effectiveness of control measures implemented to combat the intrusion of saltwater into freshwater aquifers, taking into account...
In this comprehensive study, both experimental and numerical methods are employed to investigate various strategies aimed at managing saltwater intrusion in coastal areas affected by tidal forces. The research focuses on analyzing the effectiveness of control measures implemented to combat the intrusion of saltwater into freshwater aquifers, taking into account the complex interplay between natural tidal patterns and man-made interventions. Through this integrated approach, a detailed examination of how different factors influence saltwater intrusion dynamics is conducted, providing valuable insights essential for sustainable coastal water resource management practices. (Civil Engineering)
Modeling Travel Time for Two-lane Highways
26/09/2023
Inventors: Durgesh Vikram
Travel time for two-lane highways can be effectively predicted and analyzed through advanced modeling techniques, allowing transportation professionals to make informed decisions regarding route planning, traffic management, and infrastructure development. By employing sophisticated algorithms that consider various factors such as road geometry, traffic volume, and speed limits, these models can...
Travel time for two-lane highways can be effectively predicted and analyzed through advanced modeling techniques, allowing transportation professionals to make informed decisions regarding route planning, traffic management, and infrastructure development. By employing sophisticated algorithms that consider various factors such as road geometry, traffic volume, and speed limits, these models can provide accurate estimates of travel duration, enabling stakeholders to optimize roadway performance and enhance overall transportation efficiency. (Civil Engineering)
Design and Synthesis of Inhibitors of Mycobactgerium tuberculosis sigma factor RNAP protein-protein interaction as potential Antimycobacterial Agents
27/12/2021
Inventors: Sandeep Sundriyal, Syamantak Majumder
The main objective of the research project is to create novel inhibitors specifically tailored to target the protein-protein interaction involving the sigma factor RNA polymerase of Mycobacterium tuberculosis. By focusing on designing and synthesizing these inhibitors, the ultimate goal is to develop effective antimycobacterial agents that can combat tuberculosis infections...
The main objective of the research project is to create novel inhibitors specifically tailored to target the protein-protein interaction involving the sigma factor RNA polymerase of Mycobacterium tuberculosis. By focusing on designing and synthesizing these inhibitors, the ultimate goal is to develop effective antimycobacterial agents that can combat tuberculosis infections more efficiently. This approach involves studying the molecular mechanisms involved in the interaction process and formulating compounds that can disrupt this crucial pathway, ultimately leading to the identification of potential drug candidates for further testing and development in the fight against tuberculosis. (Pharmacy)
Tweaks of Triplet State Photochemistry for Human and Disease Research
27/12/2022
Inventors: Avik Kumar Pati
The optimization of triplet state photochemistry presents promising opportunities for advancing research in both human health and disease-related studies. These subtle adjustments in the mechanisms of triplet state reactions could significantly impact the field, offering new insights into biological processes and potential therapeutic interventions. By delving deeper into the intricacies...
The optimization of triplet state photochemistry presents promising opportunities for advancing research in both human health and disease-related studies. These subtle adjustments in the mechanisms of triplet state reactions could significantly impact the field, offering new insights into biological processes and potential therapeutic interventions. By delving deeper into the intricacies of this photochemical process, researchers aim to unlock a deeper understanding of various conditions, paving the way for innovative treatments and diagnostic tools. This nuanced approach underscores the critical role that photochemistry plays in shaping the landscape of medical research and its implications for human well-being. (Chemistry)
Understanding the role of Nuclear Membrane associated proteins under differential flow dynamics driving EMT and survival of tumor cells
27/06/2023
Inventors: Sudeshna Mukherjee, Venkatesh K P
In this study, we aim to investigate the intricate mechanisms governing the functions of nuclear membrane associated proteins in response to varying flow dynamics, particularly in driving the processes of epithelial-mesenchymal transition (EMT) and promoting the survival of tumor cells. Our research seeks to shed light on how these proteins...
In this study, we aim to investigate the intricate mechanisms governing the functions of nuclear membrane associated proteins in response to varying flow dynamics, particularly in driving the processes of epithelial-mesenchymal transition (EMT) and promoting the survival of tumor cells. Our research seeks to shed light on how these proteins interact under different fluid conditions and their crucial roles in dictating the behavior and fate of cancer cells. By exploring these relationships, we hope to enhance our understanding of the molecular events that underlie tumor progression and identify potential targets for therapeutic interventions. (Biological Sciences)
On the theoretical studies of Vortex Electron impact scattering and ionization of atoms and molecules
28/01/2022
Inventors: Rakesh Choubisa
The theoretical studies focusing on vortex electron impact scattering and ionization of atoms and molecules investigate the intricate interactions between charged particles and matter, shedding light on the fundamental processes that drive atomic and molecular dynamics in the realm of quantum mechanics. By exploring the complex mechanisms of vortex electron...
The theoretical studies focusing on vortex electron impact scattering and ionization of atoms and molecules investigate the intricate interactions between charged particles and matter, shedding light on the fundamental processes that drive atomic and molecular dynamics in the realm of quantum mechanics. By exploring the complex mechanisms of vortex electron impact, researchers aim to gain deeper insights into the behavior of atoms and molecules under external influence, ultimately contributing to the advancement of theoretical models in the field of atomic and molecular physics. (Physics)
Enriching Unnatural Amino Acids (UAAs) Toolkit via Transition-metal Catalyzed Site Selective Functionalization/Annulation of Distal C(sp2)-H bonds
28/10/2021
Inventors: Rajeev Sakhuja
In our research, we aim to enhance the repertoire of Unnatural Amino Acids (UAAs) by developing a sophisticated toolkit through the innovation of Transition-metal Catalyzed Site Selective Functionalization and Annulation. Our primary focus lies in the strategic transformation of distal C(sp2)-H bonds to achieve targeted modifications of amino acids. This...
In our research, we aim to enhance the repertoire of Unnatural Amino Acids (UAAs) by developing a sophisticated toolkit through the innovation of Transition-metal Catalyzed Site Selective Functionalization and Annulation. Our primary focus lies in the strategic transformation of distal C(sp2)-H bonds to achieve targeted modifications of amino acids. This cutting-edge approach not only broadens the scope of synthetic chemistry but also paves the way for novel applications in drug discovery, materials science, and chemical biology. Our goal is to revolutionize UAA synthesis and utilization by leveraging the power of transition-metal catalysis and precise site-specific functionalization. (Chemistry)
Structured Dialogues for Sustaibable Urban Water Management (SDSUWM)
28/11/2019
Inventors: Rajiv Gupta
Structured Dialogues for sustainable urban water management (SDSUWM) serve as a platform for engaging diverse stakeholders, including government bodies, environmental groups, and the public, in collaborative discussions aimed at finding innovative solutions to water-related challenges in urban areas. These dialogues encourage knowledge-sharing, facilitate the exchange of best practices, and promote...
Structured Dialogues for sustainable urban water management (SDSUWM) serve as a platform for engaging diverse stakeholders, including government bodies, environmental groups, and the public, in collaborative discussions aimed at finding innovative solutions to water-related challenges in urban areas. These dialogues encourage knowledge-sharing, facilitate the exchange of best practices, and promote cooperation among different sectors to achieve more efficient and environmentally friendly water management strategies. By fostering open communication and participation, SDSUWM initiatives help build consensus, raise awareness about the importance of sustainable water practices, and contribute to the overall resilience and well-being of urban communities. (Civil Engineering)
Social Media Socialization and Self-engagement: A Qualitative Study of Online Identity Reconstruction
28/03/2023
Inventors: Anupam Yadav
In this qualitative study titled "Social Media Socialization and Self-engagement," we delve into the intricate process of online identity reconstruction. By exploring how individuals interact and engage with various social media platforms, we aim to uncover the ways in which self-perception is shaped in the digital realm. Through qualitative analysis,...
In this qualitative study titled "Social Media Socialization and Self-engagement," we delve into the intricate process of online identity reconstruction. By exploring how individuals interact and engage with various social media platforms, we aim to uncover the ways in which self-perception is shaped in the digital realm. Through qualitative analysis, we seek to understand the impact of social media on personal identity formation and how individuals navigate the complexities of presenting themselves online. This research sheds light on the evolving landscape of socialization in the digital age and provides insights into the role of online platforms in shaping our identities. (Humanities & Social Sciences)
Design, Synthesis, and Evaluation of novel Dual Inhibitors of Angiotensin-II type 1 Receptor and Neprilysin for the treatment of Diabetic Cardiomyopathy
28/08/2023
Inventors: Hemant Jadhav, Gaikwad Anil Bhanudas
The overarching goal of this research project is to meticulously craft, synthesize, and meticulously evaluate groundbreaking novel dual inhibitors targeting both the Angiotensin-II type 1 receptor and Neprilysin. These innovative inhibitors are being developed with a specific focus on addressing the complex issue of diabetic cardiomyopathy, a serious condition that...
The overarching goal of this research project is to meticulously craft, synthesize, and meticulously evaluate groundbreaking novel dual inhibitors targeting both the Angiotensin-II type 1 receptor and Neprilysin. These innovative inhibitors are being developed with a specific focus on addressing the complex issue of diabetic cardiomyopathy, a serious condition that affects the heart muscle in diabetic patients. By combining the unique properties of these inhibitors, our aim is to provide a potential therapeutic solution that can effectively target multiple pathways implicated in diabetic cardiomyopathy, ultimately offering new hope for improved treatment outcomes in patients suffering from this debilitating condition. (Pharmacy)
