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Prof. Kavi Devraj

Associate Professor
Department of Biological Sciences

Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Publications

H-Index: 24  Google Scholar Link 

Journal Articles: 41  (First Author: 6, Senior/Corresponding Author: 12)

Conference Abstracts: 16

*Equal Contribution ;   Senior/corresponding author 

 
JOURNAL ARTICLES 
  1. Laub V*, Devraj K*, Elias L, Schulte D. Bioinformatics for Wetlab Scientists: Practical Application in Sequencing Analysis. BMC Genomics  2023 (in press)
  2. Spitzer D, Pütz T, Khel MI, Zinke J, Devraj G, Jia X, Sommer K, Filipski K, Freiman T, Thorsen F, Plate KH, Reiss Y, Harter PN, Liebner S, Di Tacchio M, Guérit S*Devraj K*#. A flow-cytometry-based method for syngenic isolation of neurovascular unit cells and its application to healthy and diseased murine and human neural tissue. Nature Protocols. 2023. (in press)
  3. Spitzer D, Pütz T, Khel MI, Filipski K, Steinmetz H, Plate KH, Harter PN, Liebner S, Guérit S*Devraj K*#. Optimization of anti-osteopontin therapy in acute ischemic stroke. Scientific Reports. 2022. (in press)
  4. Reiss Y, Bauer S, Bastian D, Devraj K, Fidan E, Hattingen E, Liebner S, Nico Melzer N, Meuth SG, Felix Rosenow F, Theodor R, Willems LM, Plate KH. Neurovasculature as a target in epilepsy. Brain Pathology 2022 (in press)
  5. Schumacher L, Slimani R, Zizmare L, Ehlers J, Borgmann FK, Fitzgerald JC, Fallier-Becker P, Anja Beckmann A, Grissmer A, Meier C, El-Ayoubi A, Devraj K, Mittelbronn M, Trautwein C, Naumann U. TGF-beta modulates the integrity of the blood-brain barrier in vitro, associated with metabolic alterations in pericytes. Biomedicines  2022 (in press)
  6. Spitzer D*, Guérit S*, Pütz T, Khel MI, Armbrust M, Dunst M, Zinke J, Devraj G, Jia X, Sommer K,1 K. Filipski K, Freiman T, Looso M, Günther S, Di Tacchio M, Plate KH, Reiss Y, Liebner S, Harter PN, Devraj K#. Profiling the neurovascular unit unveils detrimental effects of osteopontin on the blood-brain barrier in acute ischemic stroke Acta Neuropathologica. 2022. (in press – June 2022).
  7. Fouani Y, Kirchhof L, Stanicek L ,Luxán G , Heumüller A, Knau A , Fischer A, Devraj K, John D, Neumann P ,Bindereif A, Boon R , Liebner S, Wittig I , Mogler C, Karimova M, Dimmeler S, Jaé N. The splicing-regulatory lncRNA NTRAS sustains vascular integrity. EMBO Reports 2022 (in press)
  8. Martin M, Vermeiren S, Bostaille N, Eubelen M, Spitzer D, Vermeersch M, Profaci CP, Pozuelo E, Toussay X, Raman-Nair J, Tebabi P, America M, De Groote A, Sanderson LE, Cabochette P, Germano RFV, Torres D, Boutry S, de Kerchove d’Exaerde A, Bellefroid EJ, Phoenix TN, Devraj K, Lacoste B, Daneman R, Liebner S, Vanhollebeke B* Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science 2022 Feb 18;375(6582)
  9. Hansen L, Lohfink N, Vutukuri R, Khel MI, Kestner RI, Macas J, Spitzer D, Ferreirós N, Gurke R, Günther S, Waltraud Pfeilschifter W*, Devraj K*#. Endothelial sphingosine-1-phosphate receptor 4 regulates blood-brain barrier permeability and promotes a homeostatic endothelial phenotype. Journal of Neuroscience2021
  10. Wirsik NM, Ehlers J, Mäder L, Ilina EI, Blank AE, Grote A, Feuerhake F, Baumgarten P, Devraj K, Harter PN, Mittelbronn M*, Naumann U*. TGF-β activates pericytes via induction of the epithelial to mesenchymal transition protein SLUG in glioblastoma. Neuropathology and Applied Neurobiology2021
  11. Winkler L, Blasig R, Breitkreuz-Korff O, Berndt P, Dithmer S, Helms HC, Puchkov D, Devraj K, Kaya M, Qin Z, Liebner S, Wolburg H, Andjelkovic A V, Rex A, Blasig IE, Haseloff RF. Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins. Journal of Cerebral Blood Flow and Metabolism 2021. 41: 132–45.
  12. Guérit S, Fidan E, Macas J, Czupalla CJ, Figueiredo R, Vijikumar A, Yalcin BH, Thom S, Winter P, Gerhardt H, Devraj K, Liebner S. Astrocyte-derived Wnt growth factors are required for endothelial blood-brain barrier maintenance. Progress in Neurobiology. 2020. 199: 101937.
  13. Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel MI, Heidemann R, Braczynski AK, Ballhorn W, Günther S, Ogunshola OO, Mittelbronn M, Ködel U, Monoranu CM, Plate KH, Hammerschmidt S, Nau R, Devraj K*#, Kempf VAJ*. HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis. Acta Neuropathologica. 2020. 140(2):183–208.
  14. Kestner R-I, Mayser F, Vutukuri R, Hansen L, Günther S, Brunkhorst R, Devraj K*#, Pfeilschifter W*. Gene expression dynamics at the neurovascular unit during early regeneration after cerebral ischemia/reperfusion injury in mice. Frontiers in Neuroscience. Frontiers; 2020;14:280.
  15. Di Tacchio M, Macas J, Weissenberger J, Sommer K, Baehr O, Steinbach JP, Senft C, Seifert V, Glas M, Herrlinger U, Krex D, Meinhardt M, Weyerbrock A, Timmer M, Goldbrunner R, Deckert M, Scheel AH, Buettner R, Grauer OM, Schittenhelm J, Tabatabai G, Harter PN, Guenther S, Devraj K, Plate KH, Reiss Y. Tumor Vessel Normalization, Immunostimulatory Reprogramming, and Improved Survival in Glioblastoma with Combined Inhibition of PD-1, Angiopoietin-2, and VEGF. Cancer Immunology Research. 2019. 7(12): 1910–27.
  16. Bernatz S, Ilina EI, Devraj K, Harter PN, Mueller K, Kleber S, Braun Y, Penski C, Renner C, Halder R, Jennewein L, Solbach C, Thorsen F, Pestalozzi BC, Mischo A, Mittelbronn M. Impact of Docetaxel on blood-brain barrier function and formation of breast cancer brain metastases. Journal of Experimental & Clinical Cancer Research. 2019. 38(1): 434
  17. Dubinski D, Hattingen E, Senft C, Seifert V, Peters KG, Reiss Y*, Devraj K*#, Plate KH*. Controversial roles for dexamethasone in glioblastoma–Opportunities for novel vascular targeting therapies. Journal of Cerebral Blood Flow & Metabolism. 2019. 39(8):1460–8.
  18. Eresch J, Stumpf M, Koch A, Vutukuri R, Ferreiros N, Schreiber Y, Schroeder K, Devraj K, Popp R, Hattenbach L-O, Pfeilschifter J, Pfeilschifter W. Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy. Investigative Ophthalmology & Visual Science 2018. 59(2):653–61.
  19. Vutukuri R, Brunkhorst R, Kestner R, Hansen L, Bouzas NF, Pfeilschifter J, Devraj K*#, Pfeilschifter W*. Alteration of sphingolipid metabolism as a putative mechanism underlying LPS‐induced BBB disruption. Journal of Neurochemistry. 2018;144(2):172–85.
  20. Devraj K, Guérit S, Macas J, Reiss Y. An in vivo blood-brain barrier permeability assay in mice using fluorescently labelled tracers. Journal of visualized experiments: JoVE; 2018;(132).
  21. Hu J, Dziumbla S, Lin J, Bibli S-I, Zukunft S, de Mos J, Awwad K, Froemel T, Jungmann A, Devraj K, Cheng Z, Wang L, Fauser S, Eberhart CG, Sodhi A, Hammock BD, Liebner S, Mueller OJ, Glaubitz C, Hammes H-P, Popp R, Fleming I. Inhibition of soluble epoxide hydrolase prevents diabetic retinopathy. Nature. 2017. 552(7684): 248-52.
  22. Friedlaender F, Bohmann F, Brunkhorst M, Chae J-H, Devraj K, Koehler Y, Kraft P, Kuhn H, Lucaciu A, Luger S, Pfeilschifter W, Sadler R, Liesz A, Scholtyschik K, Stolz L, Vutukuri R, Brunkhorst R. Reliability of infarct volumetry: Its relevance and the improvement by a software-assisted approach. Journal of Cerebral Blood Flow & Metabolism. 2017. 37(8):3015–26.
  23. Leisegang MS, Fork C, Josipovic I, Richter FM, Preussner J, Hu J, Miller MJ, Epah J, Hofmann P, Guenther S, Moll F, Valasarajan C, Heidler J, Ponomareva Y, Freiman TM, Maegdefessel L, Plate KH, Mittelbronn M, Uchida S, Kuenne C, Stellos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP. Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. Circulation. 2017. 136(1): 65-79.
  24. Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D. Cardiovascular Research. 2017. 113(6): 681–91.
  25. Stolz L, Derouiche A, Devraj K, Weber F, Brunkhorst R, Foerch C. Anticoagulation with warfarin and rivaroxaban ameliorates experimental autoimmune encephalomyelitis. Journal of Neuroinflammation. 2017. 14(1): 1–10.
  26. Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T. Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation. Journal of Cerebral Blood Flow & Metabolism. 2017 37(7):2471-84.
  27. Ziegler N, Awwad K, Fisslthaler B, Reis M, Devraj K, Corada M, Minardi SP, Dejana E, Plate KH, Fleming I, Liebner S. beta-Catenin Is Required for Endothelial Cyp1b1 Regulation Influencing Metabolic Barrier Function. Journal of Neuroscience. 2016. 36(34): 8921–35.
  28. Devraj K#, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S. BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer’s disease. Journal of Cerebral Blood Flow & Metabolism. 2016. 36(7): 1281–94.
  29. Gurnik S*, Devraj K*, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signalling. Acta Neuropathologica. 2016. 131(5): 753–73.
  30. Simpson IA, Ponnuru P, Klinger ME, Myers RL, Devraj K, Coe CL, Lubach GR, Carruthers A, Connor JR. A novel model for brain iron uptake: introducing the concept of regulation. Journal of Cerebral Blood Flow & Metabolism. 2015. 35(1):48–57.
  31. Feng Y, Gross S, Wolf NM, Butenschoen VM, Qiu Y, Devraj K, Liebner S, Kroll J, Skolnik EY, Hammes H-P, Wieland T. Nucleoside Diphosphate Kinase B Regulates Angiogenesis Through Modulation of Vascular Endothelial Growth Factor Receptor Type 2 and Endothelial Adherens Junction Proteins. Arteriosclerosis Thrombosis & Vascular biology. 2014. 34(10): 2292-300.
  32. Ridder K, Keller S, Dams M, Rupp A-K, Schlaudraff J, Del Turco D, Starmann J, Macas J, Karpova D, Devraj K, Depboylu C, Landfried B, Arnold B, Plate KH, Hoeglinger G, Sueltmann H, Altevogt P, Momma S. Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation. PLOS Biology. 2014. 12(6): e1001874
  33. Paganetti P, Antoniello K*, Devraj K*, Toni N, Kieran D, Madani R, Pihlgren M, Adolfsson O, Froestl W, Schrattenholz A, Liebner S, Havas D, Windisch M, Cirrito JR, Pfeifer A, Muhs A. Increased Efflux of Amyloid-beta Peptides through the Blood-Brain Barrier by Muscarinic Acetylcholine Receptor Inhibition Reduces Pathological Phenotypes in Mouse Models of Brain Amyloidosis. Journal of Alzheimers Disease. 2014. 38(4): 767–86.
  34. Liu H, Devraj K, Möller K, Liebner S, Hecker M, Korff T. EphrinB-mediated reverse signalling controls junctional integrity and pro-inflammatory differentiation of endothelial cells. Thrombosis and Haemostasis. 2014. 112(7):151–63.
  35. Czupalla CJ, Liebner S, Devraj K#. In vitro models of the blood–brain barrier. Methods Molecular Biology 2014. 1135: 415–37.
  36. Paolinelli R, Corada M*, Ferrarini L*, Devraj K*, Artus C, Czupalla CJ, Rudini N, Maddaluno L, Papa E, Engelhardt B, Couraud PO, Liebner S, Dejana E. Wnt Activation of Immortalized Brain Endothelial Cells as a Tool for Generating a Standardized Model of the Blood Brain Barrier In Vitro. PLoS One. 2013. 8(8): e70233
  37. Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S. Endothelial Wnt/beta-catenin signalling inhibits glioma angiogenesis and normalizes tumour blood vessels by inducing PDGF-B expression. Journal of Experimental Medicine. 2012. 209(9): 1611–27.
  38. Devraj K, Klinger ME, Myers RL, Mokashi A, Hawkins RA, Simpson IA. GLUT‐1 glucose transporters in the blood–brain barrier: Differential phosphorylation. Journal of Neuroscience Research. 2011. 89(12):1913–25.
  39. Devraj K, Geguchadze R, Klinger M, Freeman W, Mokashi A, Hawkins R, Simpson I. Improved membrane protein solubilization and clean-up for optimum two-dimensional electrophoresis utilizing GLUT-1 as a classic integral membrane protein. Journal of Neuroscience Methods. 2009;184(1):119–23.
  40. Fisher J, Devraj K, Ingram J, Slagle-Webb B, Madhankumar A, Liu X, Klinger M, Simpson IA, Connor J. Ferritin: a novel mechanism for delivery of iron to the brain and other organs. American Journal of Physiology-Cell Physiology. 2007.  293(2):C641-9
  41. Devraj K, Bonassar LJ, MacKay CA, Mason-Savas A, Gartland A, Odgren PR. A New Histomorphometric Method to Assess Growth Plate Chondrodysplasia and Its Application to the Toothless (tl, Csf1 null Osteopetrotic Rat. Connective Tissue Research. 2004. 45(1):1–10.
 
CONFERENCE ABSTRACTS
  1. Fidan E, Bader F, Plate KH, Harter P, S Guenther S, Freiman T, Konczalla J, Devraj K, Liebner S Increased expression of chemokine receptor CXCR4 in astrocyte endfeet at the neuro-vascular unit from mesial temporal lobe epilepsy patients with hippocampus sclerosis. Glia 2021 69, E495-E495
  2. Hu J, Dziumbla S, Lin J, Bibli S-I, Zukunft S, Devraj K, Sodhi A, Liebner S, Hammes H-P, Popp R, Fleming I. Inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy. Acta Physiologica. 2019. 227: 67-68.
  3. Hu J, Dziumbla S, Lin J, Bibli S, Devraj K, Liebner S, Hammes H, Popp R, Fleming I. P377 Inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy. Cardiovascular Research. 2018. 114: S96–S96.
  4. Eresch, J., Stumpf, M., Koch, A., Vutukuri, R., Ferreiros, N., Schreiber, Y., Schroder, K., Devraj, K., Popp, R., Huwiler, A. and Hattenbach, L.O., 2018. Sphingosine Kinase 2 Modulates Retinal Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy Investigative Ophthalmology & Visual Science. 2018 59(6), pp.2503-2503.
  5. Guérit S, Fidan E, Devraj K, C.J. Czupalla CJ, Macas J, Thom S, Plate KH, Gerhardt H, Liebner S Astrocyte-derived Wnts regulate brain vascular permeability in mice affecting BBB maintenance. Fluids and Barriers of the CNS 2017, 14(Supp 2):A19
  6. Leisegang MS, Fork C, Josipovic I, Richler F, Preussner J, Millers MJ, Epah J, Hofmann P, Anther S, Valasarajan C, Moll F, Heidler J, Ponomareva Y, Maegdefesser L, Uchida S, Kunne C, Sleilos K, Schermuly RT, Weissmann N, Devraj K, Wittig I, Boon RA, Dimmeler S, Pullamsetti SS, Looso M, Miller FJ Jr, Brandes RP. LncRNA MANTIS facilitates endothelial angiogenic function. Acta Physiologica. 2017. 219: 58-58.
  7. Stolz L, Brunkhorst R, Devraj K#. Interaction of thrombin and sphingosine-1-phosphate on blood-brain barrier function. Journal of Cerebral Blood Flow & Metabolism 2017. 37: 205–205.
  8. Dziumbla S, Hu J, Popp R, Lin J, Devraj K, Hammes H-P, Fleming I. The omega-3 diol 19, 20-dihydroxydocosapentaenoic acid regulates vascular permeability in diabetic retinopathy. Acta Physiologica. 2016. 216:213–4.
  9. Demolli S, Doddaballapur A, Stark K, Boon RA, Eckart A, Korff T, Hecker M, Manavski Y, Lucas T, Massberg S, Devraj K, Liebner S, Kaluza D, Dimmeler S. Abstract 15187: Shear Stress-regulated Mir-27b Controls Pericyte Recruitment in vitro and in vivo and Contributes to Vessel Maturation. Circulation. 2015. 32(suppl_3):A15187–A15187.
  10. Hu J, Popp R, Dziumbla S, Devraj K, Lin J, Hammes H-P, Fleming I. Pharmacological inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy. Acta Physiologica. 2015. 216: 213-4.
  11. Hu J, Popp R, Dziumbla S, Devraj K, Lin J, Hammes H, Fleming I. Inhibition of the soluble epoxide hydrolase attenuates diabetic retinopathy in ins2akita mice. Journal of vascular research. 2015. 52.
  12. Devraj G, Devraj K, Hammerschmidt S, Kempf V. Role of HIF-1 in Pneumococcal Infections at the Blood-Brain Barrier. International Journal of Medical Microbiology. 2013. 303: 60–60.
  13. Reis M, Czupalla CJ, Ziegler N, Devraj K, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Dimmeler S, Plate KH, Liebner S. Endothelial Wnt/beta-catenin signalling reduces vascularization, barrier breakdown and tumour growth in a mouse glioma model. Vascular Pharmacology. 2012. 5(56):332-32.
  14. Fisher J, Devraj K, Ingram J, Slagle-Webb B, Madhankumar A, Klinger M, Simpson I, Connor J. FERRITIN-A NOVEL MECHANISM FOR DELIVERY OF IRON TO THE BRAIN AND OTHER ORGANS: P-72. American Journal Of Hematology. 2007. 82(6): 72-72
  15. Odgren P, Gartland A, Gartland A, Devraj K, Bonassar L, MacKay C, Mason-Savas A. Osteopetrotic chondrodysplasia in the toothless (CSF-1null) rat: A paradigm for the role of osteoclastogenic factors as integrators of endochondral ossification. Bone. 2004. 34: S38–S38.