BITS Pilani

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Research Projects

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Research Projects

SANCTIONED PROJECTS (2021)


Title of the project: The sySTEMs initiative: Systems biology-augmented, stem cell-derived, multi-tissue panel for rapid screening of approved drugs as potential COVID-19 treatments
Funding agency: Medical Research Future Funds (MRFF)
Duration: 1 year
Amount (lakhs): 12
PI and Co-I: S.S.Vasan, CSIRO, Australia (PI); S. Murugesan

ONGOING PROJECTS (2021)

GOVERNMENT SPONSORED


Title of the project: Design and synthesis of inhibitors of Mycobacterium tuberculosis sigma factor-RNAP protein-protein interaction as potential antimycobacterial agents
Funding agency: ICMR
Duration: 3 years
Amount (lakhs): 41.11
PI and Co-I: Sandeep Sundriyal (PI); Gopal Balasubramanian (Co-I)

Title of the project: Computational design, synthesis and screening of non-hydroxamate lipophilic DXR inhibitors as potential antibacterial/antimalarial/anti-TB agents
Funding agency: SERB
Duration: 3 years
Amount (lakhs): 30.46
PI and Co-I: Sandeep Sundriyal (PI); Mukti N Mishra (Co-I)

Title of the project: Targeting chromatin modifiers- Jumonji Histone Demethylases in tumor cells surviving acute drug stress: an in vitro and in vivo study
Funding agency: ICMR
Duration: 3 years
Amount (lakhs): 37.10
PI and Co-I: Rajdeep Chowdhary (PI); Sandeep Sundriyal (Co-I)

Title of the project: Klotho regulation as a novel therapeutic strategy against acute kidney injury-diabetes comorbidity: Impact of epigenetic driven and epigenetic independent reactivation of endogenous Klotho expression.
Funding agency: SERB
Duration: 3 years
Amount (lakhs): 50.33
PI and Co-I: Gaikwad Anil Bhanudas (PI)

Title of the project: Exploring the mechanism(s) of gut microbiota link to Parkinson Disease pathology and its reversal based on fibroblast growth factor 21 gene delivery through lentivirus system.
Funding agency: ICMR
Duration: 3 years
Amount (lakhs): 42.56
PI and Co-I: Rajeev Taliyan (PI); Sunil k Dubey, Amit Goyal (Co-I)

Title of the project: Exploring the effects of polyamine and associated metabolic regulation of hypothalamic GnRH-GnIH synthesis and release during ageing in BALB/cJ mice.
Funding agency: SERB
Duration: 3 years
Amount (lakhs): 34.35
PI and Co-I: Dr. Arnab Banerjee, BITS Goa (PI); Rajeev Taliyan (Co-I)

Title of the project: Peptide-tethered multifunctional cationic nanocomplexes for delivery of IL- 1 receptor antagonist for treatment of type 2 diabetes mellitus
Funding agency: SERB
Duration: 3 years
Amount (lakhs): 40.46
PI and Co-I: Anupama Mittal (PI); Deepak Chitkara (Co-I)

Title of the project: Development of a complete skin substitute by autologous cell grafting using an in-situ forming bioactive scaffold for burn wound healing
Funding agency: DBT
Duration: 1.5 years
Amount (lakhs): 25
PI and Co-I: Aniruddha Roy (PI); Archana Singh (IGIB) (Co-I)

Title of the project: Develop of novel anti-leishmanial analogues loaded with novel nano- formulations
Funding agency: DBT
Duration: 3 years
Amount (lakhs): 60
PI and Co-I: S. Murugesan (PI); K.V.G.Chandrasekhar (Co-I)

Title of the project: Design, Synthesis, Biological Evaluation and Molecular Modelling Studies of Indolyl Oxoacetamide Quinazolinone Based Hybrid Analogs as Potential Pancreatic Lipase Inhibitors for Obesity Treatment
Funding agency: DST
Duration: 3 years
Amount (lakhs): 35
PI and Co-I: Atish T Paul (PI)

Title of the project: Gel-based composite formulation containing asiaticoside and neurotensin for rapid healing of diabetic wounds
Funding agency: ICMR
Duration: 3 years
Amount (lakhs): 25.67
PI and Co-I: Anupama Mittal (PI); Deepak Chitkara (Co-I)

Title of the project: Self-assembling, pH-sensitive temozolomide conjugate nanomedicine for treatment of glioblastoma multiforme
Funding agency: ICMR
Duration: 3 years
Amount (lakhs): 25.27
PI and Co-I: Deepak Chitkara(PI); Anupama Mittal(Co-I)

Title of the project: cRGD decorated lipo-polymeric nanoplexes of CRISPR/Cas9 ribonucleoprotein (RNP) for the management of retinal dystrophic conditions
Funding agency: DBT
Duration: 3 years
Amount (lakhs): 125.214
PI and Co-I: Deepak Chitkara(PI); Anupama Mittal (Co-I)

Title of the project: Discovery of myeloperoxidase (MPO) inhibitors for the potential treatment of critically ill COVID-19 patients with cytokine storm.
Funding agency: IIT Delhi
Duration: 3 years
Amount (lakhs): 10
PI and Co-I: Vaibhav A. Dixit (PI); Atish Paul (Co-I)

Title of the project: Health TB project: Design and synthesis of Mycobacterium UDG inhibitors
Funding agency: The Office of PSA
Duration: 2 years
Amount (lakhs): 10
PI: Sandeep Sundriyal

Title of the project: Development and evaluation of lipid based nanoparticles of Quinapyramine and Isometamidium chloride for treatment of trypanosomiasis in camels
Funding agency: DBT
Duration: 3 years
Amount (lakhs): 44.72
PI and Co-I: Anil Jindal (PI); Samar Ghorui (NRCC, Bikaner), Atish Paul (Co-I)

Title of the project: Rod-shaped polymeric nanoparticles for targeted delivery of artemisinin- derivatives to plasmodium-infected erythrocytes for improved intravenous therapy of cerebral malaria
Funding agency: SERB
Duration: 3 years
Amount (lakhs): 44.30
PI: Anil Jindal (PI)

Title of the project: Peptide-decorated pH-sensitive nano-conjugate hybrid micelles for co- delivery of temozolamide and an autophagy inducer, rapamycin, for treatment of glioblastoma multiforme.
Funding agency: DBT
Duration: 3 years
Amount (lakhs): 41.94
PI and Co-I: Deepak Chitkara (PI); Gaikwad Anil Bhanudas (Co-I)

Title of the project: Actively targeted nano-formulations for co-delivery of a taxane and antioxidant molecule, alpha lipoic acid, for treating breast cancer.
Funding agency: DST-Rajasthan
Duration: 3 years
Amount (lakhs): 11.13
PI: Deepak Chitkara (PI);

Title of the project: Exploiting the electron transfer (ET) parameters for the prediction of selectivities in Cytochrome P450 (CYP450) catalyzed biotransformations of industrial importance.
Funding agency: NSM, DST, New Delhi
Duration: 2 years
Amount (lakhs): 19.16
PI and Co-I: Vaibhav A. Dixit (PI); Priyanka Bajaj (Co-I)

INDUSTRY SPONSORED


Title of the project: Pharmacological and Safety Evaluation of Protein Based Ketogenic Diet Supplement in STZ induced Alzheimer’s Type of Dementia in rat
Funding agency: Zeon Ltd.
Duration: 2 years
Amount (lakhs): 6.72
PI: Rajeev Taliyan

Title of the project: Nanotechnology based pharmaceuticals, nutraceuticals and cosmetics: development of platform technology.
Funding agency: Incisive Element LLC, USA (Industry Sponsored)
Duration: 3 years
Amount (lakhs): 21.37
PI: Deepak Chitkara

Title of the project: In vitro-In Vivo study design: Evaluation of Cardio-reno Protective Effect of Herbal extract and its molecular mechanisms (Role of NO-cGMP pathway)
Funding agency: Etica ClinPharma
Duration: 2 years
Amount (lakhs): 9.92
PI and Co-I: Rajeev Taliyan (PI); Sunil K Dubey (Co-I)

INTERNATIONAL SPONSORED


Title of the project: Development of a Triggered Release Nano-Formulation for Combined Chemo-Immunotherapy of Cancer
Funding agency: Shastri Indo-Canadian Institute
Duration: 2 years
Amount (lakhs): 10
PI and Co-I: Aniruddha Roy (PI); Shyh-Dar Li (UBC) (Co-I)

Title of the project: Development of novel anti-leishmanial analogues loaded with novel nano- formulations
Funding agency: DBT (Indo-Spain)
Duration: 3 years
Amount (lakhs): 60
PI and Co-I: S. Murugesan (PI); K.V.G.Chandra Sekhar (BITS Pilani, Hyderabad Campus) (Co-I)

INSTITUTE SPONSORED


Title of the project: RedoxWare: Exploting the redox enzyme property differences for drug discovery and biotechnological applications
Funding agency: ACRG
Duration: 2 years
Amount (lakhs): 7.5
PI: Vaibhav A. Dixit (PI)

Title of the project: To Decipher the role of oxidative stress-induced inhibition of PKM2 in regulating autophagic induction of Nrf2: Understanding the mechanism of ROS adaptation in breast cancer cells.
Funding agency: ACRG
Duration: 2 years
Amount (lakhs): 1.5
PI: Richa Shrivastava (PI)

PROJECTS COMPLETED IN 2021


Title of the project: Umbilical Cord Mesenchymal Stem Cells Derived Exosomes as Biogenic Nanocarriers of miRNA and Chemotherapeutic Drug for Reversal of Chemoresistance in Breast Cancer
Funding agency: DST-Nanomission
Duration: 3.5 years
Amount (lakhs): 56.46
PI and Co-I: Anupama Mittal (PI); Swasti Tiwari & Amrit Gupta (SGPGI, Lucknow) (Co-I)

Title of the project: To study the role of hyperglycemia on the progression of acute kidney injury
Funding agency: SERB
Duration: 3 years
Amount (lakhs): 47.18
PI: Gaikwad Anil Bhanudas

Title of the project: Exploring the synergism of PPAR-γ agonist and HDAC inhibitor for reversal of Alzheimer’s type of dementia and developing their brain targeted nano-carrier system for effective treatment”
Funding agency: DST- Nano
Duration: 3 years
Amount (lakhs): 32.13
PI and Co-I: Rajeev Taliyan (PI); Deepak Chitkara (Co-I)

Title of the project: Cyclic RGD modified lipopolymeric micelles for targeted delivery of Tamoxifen in ER+ breast cancer
Funding agency: DST- Rajasthan
Duration: 3 years
Amount (lakhs): 12.53
PI: Anupama Mittal

Title of the project: Quality by design based suspension product development and process optimization
Funding agency: Slayback Pharma, Hyderabad, India
Duration: 2 years 6 months
Amount (lakhs): 5.2
PI and Co-I: Gautam Singhvi (PI); Sunil K Dubey (Co-I)

Title of the project: Design of novel ophthalmic drug delivery system
Funding agency: Slayback Pharma, Hyderabad, India
Duration: 2 years 5 months
Amount (lakhs): 7
PI and Co-I: Gautam Singhvi (PI); R.N Saha (Co-I)

Title of the project: Design and Synthesis of conformationally constrained cationic peptidomimetics (CPMs) as antimicrobial agents
Funding agency: ACRG
Duration: 2 years
Amount (lakhs): 9.5
PI and Co-I: Sandeep Sundriyal (PI)

PROJECTS COMPLETED IN 2020


Title of the project : Exploring the synergism of PPAR-γ agonist and HDAC inhibitor for reversal of Alzheimer’s type of dementia and developing their brain targeted nano-carrier system for effective treatment
Funding agency: DST-Nano
Duration: 3 years
Amount (lakhs): 32,13,820
PI and Co-I: Rajeev Taliyan (PI), Deepak Chitkara (Co-I)

Title of the project : Quality by design based suspension product development and process optimization
Funding agency: Slayback Pharma, Hyderabad, India
Duration: 2.5 years
Amount (lakhs): 5,20,000
PI and Co-I: Gautam Singhvi (PI), Sunil K Dubey (Co-I)

Title of the project : Design of novel ophthalmic drug delivery systems
Funding agency: Slayback Pharma, Hyderabad, India
Duration: 2 years
Amount (lakhs): 7,00,000
PI and Co-I: Gautam Singhvi (PI), R.N Saha (Co-I)

PROJECTS COMPLETED IN 2019


Title of the project: Design of Healthcare Supply Chain for Enhancing Availability and Reducing Wastage of Generic Medicines for Rural Areas in Rajasthan.
Funding agency: DST Rajasthan
Duration: 3 years
Amount (lakhs): 5.88
PI and Co-I: Srikanta Routroy (PI); Sunil K Dubey (Co-I)

Title of the project: Insight into dissolution mechanism of amorphous solid dispersions of macitentan
Funding agency: DBT- Foldscope
Duration: 3 years
Amount (lakhs): 8
PI: Murali Manohar Pandey

Title of the project: To study the protective effects of Herbal formulation against Myocardial Ischemia reperfusion injury in rats.
Funding agency: Etica Clinpharm Pvt Ltd
Duration: 3 years
Amount (lakhs): 4
PI: Rajeev Taliyan and Sunil K Dubey

Title of the project: Development of nanoemulsion based formulations of bioactives
Funding agency: Ananta Medicare
Duration: 3 years
Amount (lakhs): 5.1
PI: Anil Jindal

Title of the project: Preliminary investigation, characterization and stability analysis of micelles formulation.
Funding agency: Enaltec Pharma Research Private Limited
Duration: 3 years
Amount (lakhs): 1.41
PI: Sunil K Dubey and Gautam Singhvi

Title of the project: Preparation and characterization of chitosan nanoparticles prepared using a novel micellar system to deliver poorly water soluble drugs.
Funding agency:
Duration: 3 years
Amount (lakhs): 2
PI: Aniruddha Roy

PROJECTS COMPLETED IN 2018


Title of the project : Role of Histone Ubiquitination & Angiotensin Converting Enzyme 2 in the Development of Renal Fibrosis under Type 1 Diabetic condition.
Funding agency: CSIR-EMR
Duration: 3 years
Amount (lakhs): 14.86
PI: Gaikwad Anil Bhanudas

Title of the project : Exploring The Anti-obesity Potential of Selected Ayurvedic Medicinal Plants Using Pancreatic Lipase Inhibition Assay and Synergy Guided Fractionation Approach
Funding agency: DST-SERB
Duration: 3 years
Amount (lakhs): 27.30
PI: Atish T Paul

Title of the project : Combination delivery of small molecules and microRNA for treatment of locally advanced and metastatic breast cancer
Funding agency: DST-SERB
Duration: 3 years
Amount (lakhs): 27.20
PI: Deepak Chitkara

Title of the project : Nano-formulation of lysophylline-fatty acid conjugate for effective treatment of diabetes
Funding agency: DST-SERB
Duration: 3 years
Amount (lakhs): 26.90
PI: Anupama Mittal

Title of the project : Design and characterization of nanocrystals of poorly soluble drug for enhancement of dissolution and oral bioavailability
Funding agency: BITS Pilani (RIG)
Duration: 3 years
Amount (lakhs): 1.50
PI: Murali M Pandey

Research Collaborations

  • Incisive Element LLC, USA
  • Etica ClinPharma
  • Slayback Pharma, Hyderabad, India
  • Morningside Healthcare Ltd
  • Colorcon Asia Private Limited
  • Oniosome Healthcare Private limited
  • Intas Pharmaceutical Ltd
  • GlaxoSmithKline Pharmaceuticals Ltd.
  • Lupin Pharmaceuticals Inc.

Collaborations

  • Collaborations

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