Prof. Vivek Sharma

Associate Professor
Department of Biological Sciences

Role of Non-coding RNAs in regulation of gene expression in cancer and neuroinflammation
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Room No. B209, Department Of Biological Sciences Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India


Google Scholar



  • Tripathi S, Sengar S, Shree B, Mohapatra S, Basu A*, Sharma V*. An RBM10 and NF-κB interacting host lncRNA promotes JEV replication and neuronal cell death.Journal of Virology. 2023. Vol 97 No.12. doi: (*Corresponding Author)


  • Mohapatra S, Tripathi S, Sharma V*, Basu A*. Regulation of microglia-mediated inflammation by host lncRNA Gm20559 upon flaviviral infection. Cytokine. 2023.172:156383. doi: 10.1016/j.cyto.2023.156383. (*Corresponding Author)


  • Priyadarshini N, Venkatarama Puppala N, Jayaprakash JP, Khandelia P, Sharma V, Mohannath G. Downregulation of ribosomal RNA (rRNA) genes in human head and neck squamous cell carcinoma (HNSCC) cells correlates with rDNA promoter hypermethylation. Gene. 2023 Dec 20;888:147793. doi: 10.1016/j.gene.2023.147793


  • Shree B, Sharma V*. Role of Non-Coding RNAs in TGF-β Signalling in Glioma. Brain Sci. 2023 Sep 27;13(10):1376. doi: 10.3390/brainsci13101376. (*Corresponding Author)


  • Nandikolla A, Khetmalis YM, Sangeetha GPV, A Chandu, Swati, MMK Kumar, Sharma V, Murugesan S, Chandra Sekhar K V G Tetrahydroisoquinoline based 5-nitro-2-furoic acid derivatives: a promising new approach for anti-tubercular agents. 2023 New Journal of Chemistry 47 (32), 15378-15389


  • Khetmalis YM, Sangeetha GP, Chandu A, Swati, Murugesan S, Sharma V, Kumar MM, Kondapalli VG. Design, synthesis and biological evaluation of novel oxindole analogs as antitubercular agents. Future Medicinal Chemistry 2023. Aug;15(15):1323-1342. doi: 10.4155/fmc-2023-0066


  • Khetmalis YM, Shree B, Kumar BVS, Das K, Schweipert M, Debarnot C, Ashna F, Sankarnarayanan M, Trinath J, Sharma V, Almes FJM, Chadra Shekhar KVG. Design synthesis and biological evaluation of tetrahydroisoquinoline based hydroxamate derivatives as HDAC6 inhibitors for cancer therapy. J Molecular Structure. 2023,(1278).


  • Shree B*, Das K,  Sharma V*. Emerging role of  transforming growth factor-beta  regulated long non-coding RNAs in prostate cancer pathogenesis. Cancer Pathogenesis and Therapy  2023 (Vol I issue 3 195-204). (*Corresponding Author)


  • Shree B, Sengar S, Tripathi S, Sharma V*. LINC01711 promotes Transforming growth factor-beta (TGF-β) induced  in Glioblastoma multiforme (GBM) by acting as a competing endogenous RNA for miR-34a and promoting ZEB1 expression. Neuroscience Letters. 2023 (792) 136937. (*Corresponding Author)


  • Roy S, Chakrabarti M, Dasgupta H, Mahale A, Tripathi S, Sharma V, Banerjee M, Kulkarni OP. Inhibition of Autotaxin Ameliorates LPA-mediated Neuroinflammation and Alleviates Neurological Dysfunction in Acute Hepatic Encephalopathy. ACS Chem. Neurosci.2022, 13, 19, 2829-2841


  • Swati, Sharma V*. The interplay of Cytokine Signaling and Non-coding RNAs in Head and Neck Squamous Cell Carcinoma Pathobiology. Mol Biol Rep. 2022 (49) 10825-10847. (*Corresponding Author)


  • Shree B, Tripathi S, Sharma V*. Transforming growth factor-beta (TGF-β) regulated lncRNA-MUF promotes invasion by modulating miR-34a- Snail1 axis in Glioblastoma multiforme (GBM). Front. Oncol. 2022,8 Feb 2022.  ( (*Corresponding Author)


  • Tripathi S#, Shree B#, Mohapatra S, Swati, Basu A *, Sharma V*. The expanding  regulatory mechanisms and cellular functions of long non-coding RNAs (lncRNAs) in Neuroinflammation. Molecular Neurobiology. 58 (2916-2939) 2021. doi: 10.1007/s12035-020-02268-8. (* Corresponding Authors, # Equal Contribution)


  • Pulya S,  Mahale A, Bobde Y, Routholla G,  Patel T, Swati, Biswas S, Sharma V,  Kulkarni OP *, and  Ghosh B*. PT3: A Novel Benzamide Class Histone Deacetylase 3 Inhibitor Improves Learning and Memory in Novel Object Recognition Mouse Model ACS Chem. Neurosci.2021, 12, 5, 883-892


  • Rajappa A, Banerjee S ,  Sharma V* , Khandelia P*. Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics. Front Mol Biosci 2020 Oct 28;7: 577938. doi: 10.3389/fmolb.2020.577938. eCollection 2020. (*Corresponding Author) 


  • Shree B and Sharma V*. Linc‘ing’ RNA to DNA Repair. Proc Indian Natn Sci Acad 84 No. 2 June;  2018 pp. 521-529. (*Corresponding Author)


  • Sharma V *, Khurana S, Kubben N, Abdelmohsen K, Oberdoerffer P, Gorospe M, Misteli T*. A BRCA1 - interacting lncRNA regulates homologous recombination. EMBO reports . 2015, 16(11): 1520 – 1534 (*Corresponding Authors). Highlighted as news and views : A lncRNA to repair DNA. EMBO reports 2015, 16(11) : 1413 - 1414.


  • Jia L, Sun Z, Wu X, Misteli T*, Sharma V * . Gene expression analysis upon lncRNA DDSR1 knockdown in Human fibroblasts. Genom Data . 2015, 6: 277 - 279. ( * Corresponding Authors)


  • Zane L*, Sharma V * and Misteli T. Common features of chromatin in aging and cancer - cause or coincidence? Trends Cell Bio. 2014, 24 (11): 686 - 94 . (* Equal contribution). 


  • Sharma V and Misteli T. Noncoding RNAs in DNA Damage and Repair. FEBS Letters. 2013, 587(13):1832 - 39.


  • Ji J, Sharma V , Qi S, Guarch ME, Zhao P, Luo Z, Fan W, WanY, Mbabaali F, Neculai D, Esteban MA, McPherson JD, Batada NN . Antioxidants supplementation reduces genomic aberrations in human induced pluripotent stem cells. Stem Cell Reports 2014, 2(1):44 - 51. Highlighted with cover image and commentary : Cell Regeneration 2014,3:5.


  • Planello AC, Ji J, Sharma V , Singhania R, Mbabaali F, Müller F, Alfaro JA, Bock C, De Carvalho DD , Batada NN. Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming f actors . Cell Regeneration 2014, 3 :4.


  • Dixit D, Ghildiyal R, Ponnor Anto N, Ghosh S, Sharma V , Sen E. Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT - dependent manner . Cancer Lett . 2013, 336(2):347 - 58.


  • Ji J , Ng S, Sharma V , Neculai D, Hussein S, Sam M, Trinh Q, Church GM, McPherson JD, Nagy A, and Batada NN .Elevated coding mutation rate during the reprogramming of human somatic cells into induced pluripotent stem cells. Stem Cells 2012, 30(3):435 - 440.


  • Dixit D, Sharma V, Ghosh S, Mehta VS, Sen E. Inhibition of Casein kinase - 2 induces p53 - dependent cell cycle arrest and sensitizes glioblastoma cells to tum - induced apoptosis through SIRT1 inhibition . Cell Death Dis 2012 (3) e271.


  • Sharma V , Shaheen SS, Dixit D, Sen E. Farnesyltransferase Inhibitor Manumycin Targets IL1beta - Ras - HIF - 1alpha Axis in Tumor Cells of Dive rse Origin. Inflammation 2012, 35(2):516 – 9


  • Sharma V , Dixit D, Koul N, Mehta VS, Sen E. Ras regulates interleukin - 1beta- induced HIF - 1alpha transcriptional activity in glioblastoma. J Mol Med (Berl) 2011, 89(2):123 - 136. Highlighted with commentary : Kaluz S, Van Meir EG.At the crossroads of cancer and inflammation:Ras rewires an HIF - driven IL - 1 autocrine loop.J Mol Med.2011,89(2):91-4.


  • Sharma V , Dixit D, Ghosh S, Sen E. COX - 2 regulates the proliferation of glioma stem like cells. Neurochemistry international 2011, 59(5):567 - 571.


  • Sinha S, Koul N, Dixit D, Sharma V , Sen E. IGF - 1 induced HIF - 1alpha - TLR9 cross talk regulates inflamm atory responses in glioma. Cellular signalling 2011, 23(11):1869 - 1875.


  • Koul N, Sharma V , Dixit D, Ghosh S, Sen E. Bicyclic triterpenoid Iripallidal induces apoptosis and inhibits Akt/mTOR pathway in glioma cells. BMC canc er 2010, 10:328.


  • Sharma V , Koul N, Joseph C, Dixit D, Ghosh S, Sen E. HDAC inhibitor, scriptaid, i nduces glioma cell apoptosis through JNK activation and inhibits telomerase activity. Journal of cellular and molecul ar medicine 2010, 14(8):2151 - 2161.


  • Dixit D, Sharma V , Ghosh S, Koul N, Mishra PK, Sen E. Manumycin inhibits STAT3, telomerase activity, and growth of glioma cells by elevating intracellular reactive oxygen species generation . Free radical biology & medicine 2009, 47(4):364 - 374.


  • Tewari R * , Sharma V * , Koul N, Ghosh A, Joseph C, Hossain Sk U, Sen E. Ebselen abrogates TNFalpha induced pro - inflammatory response in glioblastoma. Molecular oncology 2009, 3(1):77 - 83. (* Equal contribution) 


  • Tewari R, Sharma V , Koul N, Sen E. Involvement of miltefosine - mediated ERK activation in glioma cell apoptosis through Fas regulation. Journal of neurochemistry 2008, 107(3):616 - 627.


  • Sharma V , Tewari R, Sk UH, Joseph C, Sen E. Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha) - induced apoptosis through two distinct pathways involving NF - kappaB downregulation and Fas - med iated formation of death inducing signaling complex. International journal of cancer 2008, 123(9):2204 - 2212.


  • Agarwal A, Sharma V , Tewari R, Koul N, Joseph C, Sen E. Epigallocatechin - 3 - gallate exhibits anti - tumor effec t by perturbing redox homeostasis, modulating the release of pro - inflammatory mediators and decreasing the invasiveness of glioblastoma cells. Molecular medicine reports 2008, 1(4):511 - 515.


  • Sharma V , Joseph C, Ghosh S, A garwal A, Mishra MK, Sen E. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Molecular cancer therapeutic s . 2007, 6(9):2544 - 2553.


  • Sharma V , Mishra M, Ghosh S, Tewari R, Basu A, Se th P, Sen E. Modulation of i nterleukin - 1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection. Brain research bulletin 2007, 73(1 - 3):55 - 63.


  • Ghoshal A, Das S , Ghosh S, Mishra MK, Sharma V , Koli P, Sen E, Basu A . Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis. Glia 2007, 55(5):483 - 496



Bicyclic triterpenoid Iripallidal as a novel anti - glioma and anti - neoplastic therapy in vitro. Europe Patent 2.367 784 B1 Issued January 1, 2013.



Lochab S, Ali A, Jha P, Sharma V , Abbey D, and Raghuram N (2010 ). Assay methods for nitrate assimilatory enzymes in Spirulina (Arthospira). Protocols on Algal and Cyanobacterial Research , Bagchi SN, Mohanty P and Kleinber D. (Eds). Narosa Pub. House.


Sharma V and Sen E (2009) Tumor microenvironment and inflammation: role in glioblastoma progression. Treatment of advanced stage cancers: current status and emerging frontiers , GP Talwar and OP Sood (Eds) . Narosa Pub. House.



Sharma V, Oberori HS and Raghuram N (2005). Getting in tune: The new Patents Act and Beyond. Combat Law, 4 (2), Jun - Jul 2005, pp. 44 - 47.