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Prof. Vivek Sharma

Associate Professor
Department of Biological Sciences

Role of Non-coding RNAs in regulation of gene expression in cancer and neuroinflammation
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Room No. B209, Department Of Biological Sciences Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Research Projects

One of the most significant realizations in the field of genome biology for the last decade has been that the human genome is pervasively transcribed and codes for a large number of long non-coding RNAs (lncRNAs). They play critical roles in regulating gene expression in almost all cellular processes by interacting with RNA-binding proteins(RBPs) or other coding and non-coding RNAs.

My lab is interested in understanding the role of lncRNAs, miRNAs and circRNAs as potential therapeutic targets in Cancer (Brain and Oral Cancer) and host-pathogen (virus)  interaction. Our work utilizes cutting-edge technologies from the fields of genomics, molecular biology, biochemistry, and computational biology.

These studies will provide insights into fundamental biological mechanisms and lay the foundation for novel diagnostics and treatments for human diseases.

Funding as PI
1.  ICMR 2022.  Elucidating the role of Transforming Growth Factor-β (TGF-β) regulated long-non-coding RNAs (lncRNAs) in Epithelial to mesenchymal transition (EMT) and as therapeutic targets for Oral Cancer.
 
Completed Projects
1. DBT RLS Fellowship- Identification and characterization of long non-coding RNAs involved in Genome stability. Dec 2016- March2022
2. DST SERB ECR-Understanding the role of long non-coding RNAs (lncRNAs) in transforming growth factor-beta (TGF-β) pathway in Glioblastoma. Dec2018-March 2022
3. DBT-Elucidating the role of long non-coding RNAs (lncRNAs) in neuronal cell death during Japanese Encephalitis (JE). March 19- July 21.

Projects as PI

Sanctioned Projects. Awaiting Fund Release.

1.  ICMR 2022.  Elucidating the role of Transforming Growth Factor-β (TGF-β) regulated long-non-coding RNAs (lncRNAs) in Epithelial to mesenchymal transition (EMT) and as therapeutic targets for Oral Cancer.

Completed Projects

1. DBT RLS Fellowship- Identification and characterization of long non-coding RNAs involved in Genome stability. Dec 2016- March2022

2. DST SERB ECR-Understanding the role of long non-coding RNAs (lncRNAs) in transforming growth factor-beta (TGF-β) pathway in Glioblastoma. Dec2018-March 2022

3. DBT-Elucidating the role of long non-coding RNAs (lncRNAs) in neuronal cell death during Japanese Encephalitis (JE). March 19- July 21.