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Prof. Vivek Sharma

Associate Professor
Department of Biological Sciences

Role of Non-coding RNAs in regulation of gene expression in cancer and neuroinflammation
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Room No. B209, Department Of Biological Sciences Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Research Projects

One of the most significant realizations in the field of genome biology over the last two decades has been that the human genome is pervasively transcribed and encodes a large number of long non-coding RNAs (lncRNAs). They play critical roles in regulating gene expression across all cellular processes by interacting with RNA-binding proteins (RBPs) and other coding and non-coding RNAs.

My lab is interested in understanding the role of lncRNAs, miRNAs, and circRNAs as potential therapeutic targets in Cancer (Brain and Oral Cancer) and host-pathogen (virus)  interaction. Our work utilizes cutting-edge technologies from genomics, molecular biology, biochemistry, and computational biology.

These studies will provide insights into fundamental biological mechanisms and lay the foundation for novel diagnostics and treatments for human diseases.

Current Funding as PI
1.  ANRF CRG May 2024.  Understanding the role of long non-coding RNAs (lncRNAs) during Neuroinflammation in Japanese Encephalitis.
 
Completed Projects as PI
1. ICMR.  Elucidating the role of Transforming Growth Factor-β (TGF-β) regulated long-non-coding RNAs (lncRNAs) in Epithelial to mesenchymal transition (EMT) and as therapeutic targets for Oral Cancer. 20.3.2023 (March 23) - 19.3.26 ( March 26)
2. DBT RLS Fellowship- Identification and characterization of long non-coding RNAs involved in Genome stability. Dec 2016- March 2022
3. DST SERB ECR-Understanding the role of long non-coding RNAs (lncRNAs) in transforming growth factor-beta (TGF-β) pathway in Glioblastoma. Dec 2018-March 2022
4. DBT-Elucidating the role of long non-coding RNAs (lncRNAs) in neuronal cell death during Japanese Encephalitis (JE). March 19- March 21
 
Completed Projects as Co-PI
1. ICMR-  28.2.23-27.2.26. HDAC3 and its Functional Role in the Progression of Cognitive Deficits as a Secondary Complication to Chronic Kidney Disease.  
2. CSIR-  Role of m6A reversible RNA methylation in oral cancer.  
 
 

Projects as PI

Sanctioned Projects. Awaiting Fund Release.

1.  ICMR 2022.  Elucidating the role of Transforming Growth Factor-β (TGF-β) regulated long-non-coding RNAs (lncRNAs) in Epithelial to mesenchymal transition (EMT) and as therapeutic targets for Oral Cancer.

Completed Projects

1. DBT RLS Fellowship- Identification and characterization of long non-coding RNAs involved in Genome stability. Dec 2016- March2022

2. DST SERB ECR-Understanding the role of long non-coding RNAs (lncRNAs) in transforming growth factor-beta (TGF-β) pathway in Glioblastoma. Dec2018-March 2022

3. DBT-Elucidating the role of long non-coding RNAs (lncRNAs) in neuronal cell death during Japanese Encephalitis (JE). March 19- July 21.