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Prof. Nirmal Jayabalan

Associate Professor
Department of Pharmacy

Ocular Drug Delivery
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Highlights of TPRL

In News       
  • The Times of India September 26th 2023: BITS-Hyd holds drive for medical waste disposal (Click Here). 

Students Fellowship/Awards/Achievements

 

  • Shridula Sankar (PhD Scholar) received CSIR SRF, January 2024.
  • Kendre Sandhya Rani (PhD Scholar) received UGC JRF, August 2023.
  • Sai Shreya Cheruvu (PhD Scholar) received the Lady Tata Memorial Trust Fellowship (LTMT), August 2023.
  • Manisha Malani (PhD Scholar) was awarded with travel fellowship from ARVO-India to attend the 29th Annual meeting of the Indian Eye Research Group, July 2023.  
  • Paulkar Suraj Srihari (PhD Scholar) received CSIR JRF, Nov-2022.
  • Manisha Malani (PhD Scholar) received UGC SRF, Oct-2022.
  • Priyadarshini Sathe (PhD Scholar) received best clinical poster presentation award"Stable, clear nanomicelles for enhanced corneal permeation of natamycin", ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022.
  • Velmurugan K (PhD Scholar) received best oral presentation award "Enhancing the stability of amphotericin-b using polymeric patch for corneal delivery", ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022.
  • Srujana MSK  (B.Pharm. Student) was awarded "Best B.Pharmacy Student 2022", BITS-Pilani, hyderabad Campus.
  • Manthan Hiremath (B.Pharm. Student) was awarded first in "APOGEE 2022, BITS-Pilani, Pilani Campus, April 2022."
    K. Kavana (M.Pharm. Student) was awarded "Tata Medical and Healthcare Scholarship" 2020-21.
  • Manisha Malani (PhD Scholar) received best oral presentation award "Artificial Intelligence in Predicting the Drug Transporter Interaction: Understanding the Entry of Systemic Drugs into Eye", ARVO-India, 27th Annual meeting of Indian Eye Research Group, October 2021.
  • Dr. Rohit (Post. Doc.) was awarded DBT Post Doc. fellowship 2020.
  • Priyadarshini Sathe (PhD Scholar) received ICMR-SRF fellowship, April-2020.
  • Ridahunlang Nongkhlaw (PhD Student) received ICMR-SRF fellowship, April-2020.
  • Manisha Malani (PhD Scholar) received UGC JRF, Sep-2019.
Students Publication
  • Article "Extracellular vesicle-associated Complement cascade 8 - alpha and Calpain-2 in Human vitreous as biomarkers of Infectious Endophthalmitis Authoured by Velmurugan K (PhD Scholar), published in Translational Vision Science & Technology (TVST), 2024, doi: https://doi.org/10.1167%2Ftvst.13.5.14 Impact factor-3.2.

  • Article "Nanomicelles empower natamycin in treating fungal keratitis: An in vitro, ex vivo and in vivo study" Authoured by Priyadarshini Sathe (PhD Scholar) and Velmurugan K.(PhD Scholar), published in International Journal of Pharmaceutics,2024, doi: https://doi.org/10.1016/j.ijpharm.2024.124118 Impact Factor 5.8  

  • Article "Combination of self-assembling system and N,O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug " Authored by Velmurugan K (PhD Scholar), published in European Journal of Pharmaceutics and Biopharmaceutics, 2024 doi: 10.1016/j.ejpb.2024.114208 Impact factor 4.9. 
  • Article "A Promising ‘Single’ and ‘Dual’ Drug-Nanocomposite Enriched Contact Lens for the Management of Glaucoma in Response to Tear Fluid Enzyme " Authored by Velmurugan K (PhD Scholar), published in Journal of Materials Chemistry B, 2024 doi: 10.1039/d3tb02624h Impact factor 7.5.  
  • Article "Carboxylated nanofibrillated cellulose empowers moxifloxacin to overcome Staphylococcus aureus biofilm in bacterial keratitis" Authored by Manisha Malani (PhD Scholar), published in Carbohydrate Polymers, 2023 doi: https://doi.org/10.1016/j.carbpol.2023.121558 Impact factor 11.2.  
  • Article "Loteprednol etabonate loaded lyotropic liquid crystalline nanoparticles in-situ ophthalmic gel: Qbd driven optimization and in-vitro, ex-vivo evidence of sustained precorneal residence time" Authored by Priyadarshini Sathe (PhD Scholar), published in Journal of Drug Delivery Science and Technology, 2023 doi: https://doi.org/10.1016/j.jddst.2023.105081 Impact factor 5.  
  • Article " Interaction of systemic drugs causing ocular toxicity with organic cation transporter: an artificial intelligence prediction " Authored by Manisha Malani (PhD Scholar), Manthan S Hiremath (PhD Scholar) published in Journal of Biomolecular Structure and Dynamics, 2023 doi: https://doi.org/10.1080/07391102.2023.2226717  Impact factor 5.23.                 
  • Article "Development of Dexamethasone loaded Nanomicelles using a 3D Printed Microfluidic Device for Ocular Drug Delivery Applications" Authored by Velmurugan Kailasam (PhD Scholar) published in Sensors and Actuators A: Physical, 2023 doi: https://doi.org/10.1016/j.sna.2023.114385 Impact factor 4.29.
  • Article "Recent advances in novel formulation approaches for tacrolimus delivery in treatment of various ocular diseases" Authored by Velmurugan Kailasam (PhD Scholar)Sai Shreya Cheruvu (PhD Scholar), Manisha Malani (PhD Scholar), Srujana Mosalikanti Sai Kameshwari (B.Pharm. Student) published in Journal of Drug Delivery Science and Technology (2022), doi: 10.1016/j.jddst.2022.103945 Impact factor 5.06.
  • Article "Retinal Pathophysiological Evaluation in a Rat Model" authored by Manisha Malani (PhD Scholar) published in Journal of Visual Experiments, J. Vis. Exp.(183), e63111, doi:10.3791/63111 (2022), Impact factor 1.4.
  • Article "Repurposing pharmaceutical excipients as an antiviral agent against SARS-CoV-2" authored by Manisha Malani (PhD Scholar)Prerana Salunke (M.Pharm. Student)Shraddha Kulkarni (M.Pharm. Student) published in J Biomater Sci Polym Ed, doi: 10.1080/09205063.2021.1975020 Impact factor 3.5.
  • Article "Smartphone Enabled Miniaturized and automated temperature Controller Platform to Synthesize NiO/CuO and Nanomicelles for Electrochemicals Sensing and Ocular Drug Delivery Applications " authored by Velmurugan K (PhD Scholar) published in Biomedical Microdevices, 2021,6;23(2):31(1-13), PMID: 34091727Impact factor 2.327.
  •  Article "Injectable in-situ gel depot system for targeted delivery of biologics to the retina" authored by Dr. Rohit Bisht (Post. Doc. Fellow) published in Journal of Drug Targeting (2020) doi:10.1080/1061186X.2020.1803886 Impact factor 3.4.
  • Article "Biopolymeric hydrogels prepared via click chemistry as carriers of therapeutic modalities" authored by Dr. Rohit Bisht (Post. Doc. Fellow)Pinto Raveena (M.Pharm. Student) published in Tailor made and Functionalized Biopolymer Systems, Elsevier, 2020 doi: 10.1016/B978-0-12-821437-4.00010-4.
  • Article "Biologics: Delivery options and formulation strategies" authored by Ridahunlang Nangkhlow (PhD Scholar) published in: Drug Delivery Aspects, Volume 4: Expectations and Realities of Multifunctional Drug Delivery Systems, Elsiever Publications, 2020, Pages 115-155.doi: 10.1016/B978-0-12-821222-6.00006-3.
 

Students Placement's/ Higher Education

 
  • Srishti V D  (M.Pharm. Student) placed in Jodas Expoium Pvt. Ltd, Hyderabad, 2022.
  • Samhitha Koduganti  (M.Pharm. Student) placed in Aizant Drug Research Solutions Pvt. Ltd, Hyderabad, 2022.
  • Raj Girish Savla  (M.Pharm. Student) placed in Orbicular Pharmaceutical Technology, Hyderabad, 2022.
  • Manthan S Hiremath (B.Pharm. Student) selected for Ph.D in Birla Institute of Technology and Science, Pilani-Hyderabad Campus, 2022.
  • M.S.K Srujana (B.Pharm. Student) selected for MS specialization in Applied Drug Development in University of Wisconsin, Madison, USA, 2022.
  • Mansi Shah (B.Pharm. Student) selected for MS in Pharmaceutical Sciences in State University of New York at Buffalo, New York, 2022.
  • Sai Shreya Cheruvu (M.Pharm. Student) selected for Ph.D in Birla Institute of Technology and Science, Pilani-Hyderabad Campus, 2022.
  • Kajal Guleria (M.Pharm. Student) placed in Pfizer, Chennai, 2021.
  • Kavana K (M.Pharm. Student) placed in DataZyme, Bangalore, 2021.
  • Salunke Prerana Rajendra (M.Pharm. Student) placed in Pfizer, Chennai, 2021.
  • Shah Manushi Ketankumar (M.Pharm. Student) placed in Jodas Expoim, Hyderabad, 2021.
  • Pinto Raveena Simeona Richard (M.Pharm. Student) placed in GVK Bioscience, Hyderabad, 2021.
  • Shraddha Amarnath Kulkarni (M.Pharm. Student) placed in Cipla, Mumbai, 2021.
  • Shilpa Elsa George (B.Pharm. Student) selected for direct PhD Program at University of Colorado, USA, 2021.
  • J Sai Aarthi (M.Pharm. Student) placed in Novartis, Hyderabad 2019.
  • Shubhangi Golande (M.Pharm. Student) placed in Pfizer, Chennai 2019.
  • Swagatha Sinha (M.Pharm. Student) selected for PhD in BITS Hyderabad 2021.
  • Gajraj Rathod (B.Pharm. Student) selected in ETH Zorich MS pharmaceutical science Switzerland, 2019.
  • Tabitha Grace (B.Pharm. Student) selected for Master in neuroscience in Tel AVIV University Israel, 2021.

Students Conference presentations

  • Manisha Malani (PhD Scholar) presented free paper (oral presentation), "Topical Eye Drop to Prevent the Entry of Anticancer Drugs into the Eye" in the ARVO Annual Meeting held at Seattle,USA,May 2024.
  • Shridula Sankar (PhD Scholar) presented free paper (oral presentation), "Resveratrol loaded polymeric ocular patch for treating corneal diseases" in International conference on Integrative Approach of Ayush Medicine in Healthcare, January 2024, conducted by Captain Srinivasa Murthy Central Ayurveda Research Institute, at National Institute of Ocean Technology, Pallikaranai, Chennai, Tamil Nadu, India.
  • Raj Girish Savla (PhD Scholar) presented a poster titled, "Moxifloxacin loaded carboxylated cellulose particles to treat corneal infections" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Suraj Paulkar (PhD Scholar)presented a poster titled, "Transporter profiling of the lacrimal gland to decipher their role in ocular toxicity" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Manthan S Hiremath (PhD Scholar) presented a poster titled, "Artificial Intelligence delineates the link between Organic Anion Transporting Polypeptide1A2 and systemic drug-induced ocular toxicity" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Sai Shreya Cheruvu (PhD Scholar) presented a poster titled, "Lisinopril-loaded light-responsive in-situ gelling depot to treat retinal diseases" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Shridula Sankar (PhD Scholar) presented a poster titled, "Formulation development and characterization of nanocarriers-loaded polymeric ocular patch" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Velmurugan Kailasam (PhD Scholar) presented a poster titled, "Development of latanoprost loaded N,O-Carboxymethyl chitosan self assembling system to improve ocular residence time" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Priyadarshini Sathe (PhD Scholar) presented a poster titled, "Peptide transporter targeted drug delivery system to treat fungal keratitis" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Manisha Malani (PhD Scholar) presented a poster titled, "Functional role of Organic Cation Transporter 1 in systemic drug induced ocular toxicity" in ARVO-India, 29th Annual meeting of Indian Eye Research Group, July 2023, held at Aravind Medical Research Foundation (AMRF), Madurai, Tamil Nadu, India.
  • Shridula Sankar (PhD Scholar) presented research paper titled, "Physicochemical characterization of resveratrol mixture" in START Herb-Journey from Innovation to entrepreneurship, October 2022, organized by D Y Patil deemed to be university, Mumbai, Maharashtra. 
  • Raj Girish Savla (M.Pharm Student) presented basic science poster titled, "Amphiphilic nanomicelles for topical delivery of difluprednate", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Samhitha Sai Veda Koduganti (M.Pharm Student) presented basic science poster titled, "Comparative study of transferosomes and liposomes for improving transcleral delivery", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Vemuri Durga Srishti (M.Pharm Student) presented basic science poster titled, "Nanofibrillated cellulose carrier for treating bacterial keratitis", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Manthan S Hiremath (PhD Scholar) presented basic science poster titled, "Artificial intelligence and biophysical simulation delineates the potential role of organic anion transporter-1 in systemic drug induced ocular toxicity", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Sai Shreya Cheruvu (PhD Scholar) presented basic science poster titled, Nirmal "Efficacy of phosphodiesterase-4 inhibitor to treat anterior uveitis in invivo model", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Shridula Sankar (PhD Scholar) presented basic science poster titled, "A self-assembled resveratrol loaded nanocarriers for treating keratoconus", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • K Velmurugan (PhD scholar) presented free paper (oral presentation) titled, "Enhancing the stability of amphotericin-b using polymeric patch for corneal delivery", in ARVO 2022 held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Priyadarshini Sathe (PhD Scholar) presented clinical science poster titled "Stable, clear nanomicelles for enhanced corneal permeation of natamycin", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Manisha Malani (PhD Scholar) presented basic science poster titled, "In-silico models to comprehend the drug-transporter interaction", in ARVO-India, 28th Annual meeting of Indian Eye Research Group, September 2022, held at L V Prasad Eye Institute, Hyderabad, Telangana, India.
  • Shridula Sankar (PhD Scholar) presented in a lab challenge titled "Breaking the wall of Invasive Intervention for Keratoconus", in Falling Walls Lab Hyderabad, held at International Institute of Information Technology, Hyderabad, August 2022
  • Manisha Malani (PhD Scholar) presented poster titled, " Artificial intelligence and experimental studies to understand the role of transporters in ocular toxicity of systemic drugs", in ARVO 2022 held at Denver, Colorado, USA, May 2022.
  • Manthan Hiremath (B.Pharm. Student) presented research work titled, "In silico methods to predict interaction between systemic drugs causing ocular toxicity and organic cation transporter, APOGEE-2022, BITS-Pilani, Pilani Campus, April 2022.
  • Manisha Malani (PhD Scholar) presented research paper titled, " Membrane Transporters in Lacrimal Gland: Portal for Systemic Drugs to Enter Eye", in NBRCOM-India, 3rd National Biomedical Research Competition, December 2021.
  • Priyadarshani Sathe (PhD Scholar) presented research paper titled, "Nanocrystal formulation for poorly water-soluble drug" ARVO-India, 27th Annual meeting of Indian Eye Research Group, October 2021.
  • K Velmurugan (PhD scholar) presented research paper titled, "Stereolithography based 3d-printed microfluidic device to develop nanomicelles for ocular drug delivery" in ARVO-India, 27th Annual meeting of Indian Eye Research Group, October 2021.
  • Manisha Malani (PhD Scholar) presented research paper titled, "Artificial Intelligence in Predicting the Drug Transporter Interaction: Understanding the Entry of Systemic Drugs into Eye", in ARVO-India, 27th Annual meeting of Indian Eye Research Group, October 2021.
  • Swagata Sinha (M.Pharm. Student) presented a research paper titled, "Comparison of Various Techniques To Evaluate Encapsulation Efficiency of Model Hydrophobic Drug in Liposomes: An Experimental Study" in 71st Indian Pharmaceutical Conference, Chennai, December 20-22, 2019.