Prof. Anupam Bhattacharya

Department of Chemistry

Synthesis of fused heterocycles and their applications
Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India



About the Faculty
Ph.D (July, 2005)under supervision of Prof VS Parmar at University of Delhi.
Post Doc (Dec 2005-Dec 2007) at Department of Chemistry, Queens University, Kingston, Canada. Mentor: Prof. David L Zechel 



Research Interest

Fused heterocycle based fluorophores

Our interest lies mainly in the synthesis of small molecule based fluorophores for selective sensing of diverse cations/anions and important biological molecules like cysteine/homocysteine/glutathione. The main idea is to develop sensors with very simple scaffold which can be assembled quickly for on-site testing.

Small molecule total synthesis

Some of the molecules synthesized by our group are aplidiopsamine A (along with other marinoquinolines) and  racemic microthecaline A.

Ph D students

Students who have completed their PhD
1) Dr. Akula Mahesh Jun 2010-Nov 2015
2) Dr. Yadagiri Thigulla April 2012- Nov 2017
3) Dr. Togiti Uday Kumar Jan 2014-Nov 2019
4) Dr. Thirupathi Reddy Penjarla Jan 2016-Apr 2021
Students who are currently pursuing their PhD
1) Mr. Adarash Kumar Shukla Aug 2019
2) Ms. Anamika Bandyopadhyay Nov 2020 
3) Ms. Savita Jan 2022 




Courses taught

General Chemistry: Basic chemistry for first year undergraduate students
Chemistry Laboratory: A practical course that gives exposure to undergraduate students on various aspects of Chemistry experimentation
Organic Chemistry-I: Fundamental Organic chemistry
Chemical Experimentation Lab-I: Basic Organic Laboratory Techniques
Organic Chemistry-II: Stereochemistry and Reaction Mechanism
Instrumental Methods of Analysis: Spectroscopy and Analytical Techniques 
Organic Chemistry-III: Synthetic Organic Chemistry
Organic Chemistry-IV: Heterocyclic Chemistry and Natural Products
Advanced Heterocyclic Chemistry (for Ph. D students)
Physical Methods in Chemistry (for Ph.D. students)



Sponsored Projects

DST SERC Fast-Track
Project title: Synthesis of some selected nitrogen based heterocycles as potential anti tubercular agents
Term of project-3 years (June 2010-July 2013)
Status: Completed
CSIR Project
Project title: Synthesis of modified TosMIC & BetMIC for use as key reagents in the synthesis of boronated heterocycles
Term of project-3 years (Nov 2013-Nov 2016)
Status: Completed
CSIR Project
Project title: Design and synthesis of diverse pyrrole-pyridine based molecules as selective sensors for Zn2+ and F-
Term of project-3 years (June 2019-onwards)





Nickel-assisted selective detection of histidine and histidine-rich proteins via an ON-OFF-ON fluorescent probe and its imaging in live cellsAnamika Bandyopadhyay, Adarash Kumar Shukla, Priti Singh, Ashutosh Mahale, Shivkumar Sharma Irukuvajjula, Ramakrishna Vadrevu, Onkar P Kulkarni, Mudit Dixit, and Anupam Bhattacharya. Journal of Photochemistry & Photobiology, A: Chemistry, 2023, 443, 114885.


Visible light sensing of ions by a cyanoquinoxaline 1,4-dioxide-based probe and its applications, Savita*, Adinarayana Nandikolla*, Adarash Kumar Shukla, Kondapalli Venkata Gowri Chandra Sekhar and Anupam Bhattacharya, Dalton Transactions, 2023, 52, 4103-4111.


A modular approach to fluorescent probes: Extending the scope of β-carboline scaffold to selective fluoride sensing and its application in the visualisation of fluoride-induced ROS. Adarash Kumar Shukla, Savita, Ashutosh Mahale, Onkar P. Kulkarni and Anupam Bhattacharya. Journal of Photochemistry & Photobiology, A: Chemistry, 2023, 437, 114453


Copper acetate catalysed C–C bond formation en route to the synthesis of spiro indanedione cyclopropylpyrazolones. Thirupathi Reddy Penjarla, Adarash Kumar Shukla, Rituparna Hazra, Durba Roy, Maheshwar Kundarapu, Mudit Dixit and Anupam Bhattacharya. Organic and Biomolecular Chemistry, 2022, 20, 3779-3784.


Pyrrole-pyridine chelating motif on the β-carboline skeleton: Selective Zn2+sensing via inhibition of ESIPT. Adarash Kumar Shukla, Rituparna Hazra, Pravesh Sharma, Subit Kumar Saha, Durba Roy, Onkar Prakash Kulkarni and Anupam Bhattacharya. Dyes and Pigments, 2022, 202, 110238.


Pyrrolo[1,2-a]quinoxalines from chalcones: An alternate route. T. Uday Kumar, Adarash K Shukla and A. Bhattacharya. Tetrahedron Letters2021, 70, 153008. 


Iodine assisted synthesis of CF3 appended spirodihydrofuryl/cyclopropyl oxindoles by changing the active methylene sources. T.R. Penjarla, M. Kandarapu, R. Krishnan and A. Bhattacharya. Organic and Biomolecular Chemistry2020, 18, 9623-9631.


Fused Chromeno-Thieno/Furo-Pyridines as Potential Analogs of Lamellarin D and their Anticancer Activity Evaluation. T. Uday Kumar, Y. Bobde, S. Pulya, R. Krishnan, B. Ghosh and A. Bhattacharya. Chemistry Select, 2019, 4, 10726-10730. 


Total synthesis of the plant alkaloid racemic Microthecaline A: First example of a natural product bearing tricyclic quinoline-serrulatane scaffold. T.R. Penjarla, M. Kandarapu, S. Baquer and A. Bhattacharya. RSC Advances2019, 923289-23294. 


Iron(III) catalyzed direct C-H functionalization at the C-3 position of chromone for the synthesis of fused chromeno-quinoline scaffolds. T. Uday Kumar, D. Roy and A. Bhattacharya. Tetrahedron Letters2019, 60, 1895-1898. 


Functionalized Chitosan-Carbon Dots: A Fluorescent Probe for Detecting Trace Amount of Water in Organic Solvents. S. Pawar, T. Uday Kumar , A. Bhattacharya and A. Nag. ACS Omega 2019, 4, 11301-11311.


Metal-Enhanced Fluorescence Study in Aqueous Medium by Coupling Gold Nanoparticles and Fluorophores Using Bilayer Vesicle Platform, S. Pawar, A. Bhattacharya and A. Nag. ACS Omega2019, 4, 5983-5990. 


Selective Sensing of Iron by pyrrolo[2,3-c]quinolines, T. Uday Kumar, S. Pawar, A. Nag and Anupam Bhattacharya, Journal of Fluorescence2019, 29, 271-277.


Application of Polyphosphoric Acid-Mediated Acyl Migration for Regiospecific Synthesis of Diverse 2-Acylpyrroles from Chalcones. T. Uday Kumar, Y. Thigulla, K. Rangan and A. Bhattacharya. Journal of Heterocyclic Chemistry2019, 56, 1283-1290. 


Synthesis of 4-substituted pyrrolo [2,3-c]quinolines via microwave assisted C-N bond formation. T.R. Penjarla, M. Kandarapu, S. Baquer and A. Bhattacharya. Chemistry Select2018, 3, 9744-975.


Immobilized lipase from Lactobacillus plantarum in meat degradation and synthesis of flavor esters. S. R. Uppada, M. Akula, A. Bhattacharya and J. R. Dutta. Journal of Genetic Engineering and Biotechnology, 201715331-334.


One pot Two step Nazarov-Schmidt Rearrangement for the synthesis of δ-lactam systems. Y. Thigulla, S. Ranga, S. Ghosal, J. Subbalakshmi and A. Bhattacharya. Chemistry Select2017, 2, 9744-9750.


A straightforward and first total synthesis of Penilumamides B-D. T.R. Penjarla, M. Kandarapu, S. Baquer and A. Bhattacharya. Tetrahedron Letters2017, 58, 3347-3349.


FRET-Mediated Zn2+ Sensing in Aqueous Micellar Solution: Application in Cellular Imaging and Molecular Logic Gate. S.V. Pawar, T. Uday Kumar, P. Trivedi, B. Ghosh, A. Bhattacharya and A. Nag.  Chemistry Select2017, 2, 8731-8737.


One step synthesis of fused chromeno[4,3-b]pyrrolo[3,2-h]quinolin-7(1H)-one Compounds and their Anticancer Activity Evaluation. Y. Thigulla, T. Uday Kumar, P. Trivedi, B. Ghosh and A. Bhattacharya. Chemistry Select2017, 2, 2721-2724. 


Zn(II) Ion Sensing in Aqueous Micellar Solution using Modified Bipyridine based “Turn-On” Fluorescent Probes and its Application in Bioimaging.  S. Pawar, M. Akula, S. Labala, V. V. K. Venuganti, A. Bhattacharya and A. Nag ChemPlusChem2016, 81, 1339-1348.


Synthesis and anti-tubercular activity of fused thieno-/furo-quinoline compounds. M. Akula, P. Yogeeswari, D. Sriram, M. Jha, A. BhattacharyaRSC Advances2016, 646073-46080.


Synthesis and anti-cancer activity of 1, 4-disubstituted imidazo[4,5-c]quinolines. Y. Thigulla, M. Akula, P. Trivedi, B. Ghosh, M. Jha, A. BhattacharyaOrganic and Biomolecular Chemistry2016, 14, 876-883.


Selective detection of fluoride using fused quinoline systems: effect of pyrrole. M. Akula, Y. Thigulla, A. Nag, A. Bhattacharya. RSC Advances2015, 5, 57231-57234.  


Synthesis of 4-substituted oxazolo[4,5-c]quinolines by direct reaction at C-4 position of oxazole. M. Akula, Y. Thigulla, C. Davis, M. Jha, A. Bhattacharya. Organic and Biomolecular Chemistry2015, 13, 2600-2605. 


 Selective Zn2+ sensing using a modified bipyridine complex. M. Akula, P. Z. El-Khoury, A. Nag, A. Bhattacharya.  RSC Advances2014, 4, 25605-25608. 


New class of anti-tubercular compounds: Synthesis and anti-tubercular activity of 4-substituted pyrrolo[2,3-c]quinolines. M. Akula, J. Padma Sridevi, P. Yogeeswari, D. Sriram, A. Bhattacharya. Monatshefte fur Chemie , 2014, 145, 811-819.