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Prof. Balaram Ghosh 

Associate Professor,
Department of Pharmacy

Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

Sponsored Projects:

 

Sl. No.

Funding Agent

Title of the Project

Amount

Role

Status

Ongoing Projects

30

Blockchain for Impact (BFI)-BIOM

Preclinical Translation of AH22: A Highly Selective and Potent Novel Epigenome-Targeting Anticancer Therapeutic/Diagnostic Molecule

Rs. 46 Lakhs

 

Just approved

29

Indian Council of Medical Research (ICMR), Govt. of India

Development of aspirin hybrids for dual targeting of cyclooxygenase and histone deacetylase as treatments for colitis-associated colorectal cancer (CAC).

Rs. 60,34,814

PI

Just approved

28

Scheme for Promotion of Academic & Research Collaboration (SPARC). Prof. Swati Biswas (PI), Prof. Adam Mechler (La Trobe, Australia) Prof. Jimmy Hsia (NTU, Singapore).

Formulation-based strategy to design membrane targeting antimicrobial peptide-based therapeutics for cancer and eye infections

Rs. 71.16 Lakhs

Co-PI

01/04/2024 (2 years)

27

Department of Biotechnology (DBT) under Joint DBT-NMPB, Ministry of AYUSH Call for Proposals on Biotech Interventions in Medicinal Plants

Molecular Studies on Bacopa monnieri to evaluate the modulation of neuronal receptors for schizophrenia using cell based and

mouse models: Submitted on January 30_2020

Rs. 30

Lakhs

Co-PI

01/04/2024-31/03/2027

26

Department of Biotechnology (DBT), Govt. of India

3D-Bioprinted Contact Lens Embedding Host-Defense Peptide S100A12 as Precision Medicine for Bacterial Keratitis

39.10 Lakhs

Co-PI

(1.5 years)

25

Hetero Lab Limited, R&D

Jeedimetla, Hyderabad, Telangana – 500037 India.

Human serum albumin –based nanoparticles as an antiproteosome therapy for the treatment of advanced metastatic triple negative breast cancer

Rs. 5.0 Lakhs

Joint PI

26.06.2023-2026 (3 years)

24

Indian Council of Medical Research (ICMR), Govt. of India

Revolutionizing Phototherapy with Hypoxia-Reversing Photothermal/ Photodynamic Nanoparticles-Laden In Situ Gel for Non-Invasive Tumor Ablation in Oral Cancer

53.13 Lakhs

 

Co-PI

28.02.2024-27.02.2027

23

Indian Council of Medical Research (ICMR), Govt. of India

Antibacterial Nanozyme-Laden in situ Light-Responsive Hydrogel for Tissue Regeneration and Quorum-Sensing Inhibition to Revert Antimicrobial Resistance in Diabetic Foot Ulcers

48.02 Lakhs

 

Co-PI

3 years

22

Scheme for Transformational and Advanced Research in Sciences (STARS) for promoting translational, India-centric research in Science; implemented and managed by IISc, Bangalore

Carbon dioxide-fueled Janus Motors for Targeted Delivery of Therapeutic Cargo in Helicobacter pylori Infection

 

43.15 Lakhs

 

Co-PI

Jan 1, 2024 (3 years)

21

Indian Council of Medical Research (ICMR), Govt. of India. (Proposal ID: IIRP-2023-5411)

Development of Self-Powered Electrochromic Smart Display for Visual Detection of Folate Receptor Overexpressed Cancer Cells

Rs. 41 Lakhs

Co-PI

Feb 1, 2024 (3 years)

20

Department of Science and Technology, Government of India (CRG-SERB) File Number: CRG/2023/003045

Electrochemical green synthesis of medicinally potential organo-chalcogenides and chalcogenoxides and evaluation of their anti-cancer activities in search of novel anti-cancer agents

Rs. 43.486Lakhs

Co-PI

Jan 19, 2024 (3 years)

19

Indian Council of Medical Research (ICMR), Govt. of India

Development of epigenetic modulators as therapeutics for cognitive deficit associated with psychosis using novel selective histone deacetylase-3 inhibitors

34.84

Lakhs

PI

Ongoing 25.03.2023

– 24.03.2026

18

Indian Council of Medical Research (ICMR), Govt. of India

HDAC3 and its functional role in the progression of cognitive deficits as a secondary complication to chronic kidney disease (CKD).

31.16

Lakhs

Co-PI

Ongoing; 01.03.2023

- 28.02.2026

17

Indian Council of Medical Research (ICMR), Govt. of India

Tailor-made, Tumor-Targeted Vitaprotein Nanoparticles of Lapatinib and Letrozole as NanoChemo-Cocktail. for Hormone- Receptor-Amplified Advanced Metastatic Breast Cancers Treatment.

28.82

Lakhs

Co-PI

Ongoing; 27.01.2023

– 26.01.20226

(3 Yrs)

16

Indian Council of Medical Research (ICMR), Govt. of India

Design and development of portable acidosis kit for the rapid, trace-level

detection of Ketone bodies in biological samples

34.366

Lakhs

Co-PI

Ongoing; 01.04.2023–

31.03.2026

(3 Yrs)

15

DBT-BUILDER (Boost to University Interdisciplinary Life Science Departments for Education and Research).

Government of India

Interdisciplinary Life Science Programme for Advanced Research and Education

300

Lakhs

PI

22.7.2021 -21.7.2026 (5yr)

Completed Projects

14

Department of Health Research (DHR-ICMR). Government of India

Development of Epigenome Targeted Therapeutics with Improved Selectivity and Drug-ability for the Treatment of Cancer

30.483

Lakhs

PI

Complete 15.12.2021

to14.5.2025

13

Council of Scientific and Industrial Research (CSIR), Government of India

Development of Cost-effective, Electrophilic Trifluoromethylating Reagents and Their Application to the Syntheses of New Classes of Medicinally Potential Trifluoromethylated Heterocycles

25 Lakhs

(Received 1255830)

Co-PI

Complete (01.04.2021

-31.03.2024

(3 Yrs)

12

BITS-Pilani Hyderabad Campus

Validation of therapeutic activity in preclinical models

20 Lakhs

PI

Jan 2023 to Dec 2023

11

Council of Scientific and Industrial Research (CSIR) Government of India

Bifunctional Gene-Expression Modulating Chemotherapeutic Agents as Improved Treatment Strategy for Cancer

26.06

Lakhs

PI

01.06.201931.05.2022

10

Department of Science and Technology, Government of India (SERB-DST)

Near-Infrared Light Degradable Nanomicellar Chemo-Photodynamic Therapy using Aerobic Chlorin e6 Conjugate for Oropharyngeal Carcinomas

30.72

Co-PI

Complete 29.04.2019-28.04.2022;

3 yrs.

9

Indian Council of Medical Research (ICMR), Govt. of India

Functional role of histone deacetylase 6 (HDAC6) in the progression of oral squamous cell carcinoma: regulation of IL-1 beta expression, autophagy and epithelial- mesenchymal transition (EMT)

26 Lakhs

Co-PI

Complete

(09.09.2019 -

8.9.2022)

8

Dr. Reddy’s Laboratory (DRL), Hyderabad

Formulation development and physico-chemical/in vitro/in vivo characterization of a nano-suspension formulation of an anticancer drug.

8.01

Lakhs

PI

Complete (2018-2022)

7

Department of Science and Technology, Government of India (SERB-DST)

Design, Synthesis and Biological   Evaluation of HDAC3 Selective Inhibitors as Long-Term Memory Enhancers

29.87

Lakhs

PI

Complete 28.08.2017-

27.08.2021

6

SUN PHARMA ADVANCED RESEARCH COMPANY LTD. (SPARC), India

Chemically modified epigenome targeted anticancer drug development

29 Lakhs

PI

Completed (2016-2018)

5

Daewoong Pharmaceuticals, Seoul, Republic of Korea

Development for sustained release injectable formulations

22 Lakhs

PI

Complete 18.07.2015-17.07.2017

4

Department of Biotechnology (DBT), Government of India

Cell penetrating peptide octa- arginine anchored, multifunctional poly(amidoamine) dendrimer to promote delivery of chemotherapeutics in cancer

37 Lakhs

Co-PI

Complete 21.04.2015- 20.05.2028

3

Additional Competitive Research Grant: Birla Institute of Technology and Science- Pilani

Design and Development of Isoform Selective HDAC3 Inhibitors for the Enhancement of Long-term Memory

9 Lakhs

PI

Completed (2015-2017)

2

Department of Science and Technology (DST), Government of India (Indo-Belarus).

Tumor targeted nanomedicines for photodynamic therapy

9.58 Lakhs

Co-PI

Complete 30.03.2015-31.03.2017

1

Research Initiation Grant: Birla Institute of Technology and Science-Pilani at Hyderabad

Campus

Development of Cognitive Enhancers that Inhibit Histone Deacetylase Activity and Modulate Chromatin-mediated Neuroplasticity

2 Lakhs

PI

Complete 31.10.2013-30.10.2015

 

Sponsored Projects for SRF Fellowship

Sl. No.

Student

Funding Agent

Years

Status

Role

Amount (Rs.)

1

Prakruti Trivedi

CSIR-SRF

2017-2019

Completed

PI

10,81,600

2

Sravani Pulya

CSIR-SRF

2018-2021

Completed

PI

16,22,400

3

Tarun K Patel

ICMR-SRF

2022-2025

Completed

PI

10,81,600

4

Sripathi Nikhitha

DST-INSPIRE

2023-2028

Ongoing

PI

26,88,000

5

Darakhshan Begum

Lady Tata Memorial Trust

2025-2028

Ongoing

PI

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