Publications

Prof. Naga Mohan Kommu

Professor
Department of Biological Sciences

Epigenetic mechanisms of development, Genetics of psychiatric disorders and Genetic diagnostics, Human Molecular Genetics

A103, Birla Institute of Technology & Science, Pilani
Hyderabad Campus
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

mohankn@hyderabad.bits-pilani.ac.in

nkommu@pitt.edu

040-66303608

JOURNALS

2025

38. Mohan KN^*, Anne A, Kumar L, Chaillet JR^*. A new class of human CpG island promoters with primate-specific repeats. Scientific Reports 2025, 15(1):27630. https://www.nature.com/articles/s41598-025-11213-5

37. Reichard J, Wolff P, Xie S, Zuo K, Fullio CL, Du J, Graff S, Linde J, Yildiz CB, Pitschelatow G, Nabbefeld G, Dorp L, Vollmer J, Biemans L, Kempf S, Singh M, Mohan KN, Kuo C-C, Vogel T, Carloni P, Musall S and Geraldine Z-B. DNMT1-Mediated Regulation of Somatostatin-positive Interneuron Migration Impacts Cortical Architecture and Function. Nature Communications 2025, 16(1):6834. https://www.nature.com/articles/s41467-025-62114-0

36. Bora Yildiz C, Du J, Mohan KN, Zimmer-Bensch G, Abdolahi S. The role of lncRNAs in the interplay of signaling pathways and epigenetic mechanisms in glioma. Epigenomics 2025, 17: 125-140. https://www.tandfonline.com/doi/full/10.1080/17501911.2024.2442297

2024

35. Choudhury S, Anne A, Singh M, Chaillet JR, Mohan KN^* DNMT1 Y495C mutation interferes with maintenance methylation of imprinting control regions. Int J Biochem Cell Biol. 2024, 169:106535. https://www.sciencedirect.com/science/article/pii/S1357272524000268

34. Mohan KN^* Editorial: New insights into investigating schizophrenia as a disorder of molecular pathways. Front. Mol. Neurosci. 2024, 17:1360616. https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2024.1360616/full

2023

33. Singh M, Kkani P, Gundugurti PR, Dhagudu NK, Kumar L, Chellamuthu R, Srinivasan GK, Sontteneni S, Mohan KN^* Genome-scale copy number variant analysis in schizophrenia patients and controls from South India. Front. Mol. Neurosci. 2023,16:1268827. https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1268827/full

32. Singh M, Saxena S, Mohan KN^* DNMT1 downregulation as well as its overexpression distinctly affect mostly overlapping genes involved in similar pathways implicated in schizophrenia, autism spectrum, epilepsy, and bipolar disorders. Front. Mol. Neurosci. 2023, 16:1275697. https://www.frontiersin.org/journals/molecular-neuroscience/articles/10.3389/fnmol.2023.1275697/full

31. Choudhury S, Anne A, Pradhan P, Mohan KN^* Generation of a transgenic mouse embryonic stem cell line overexpressing DNMT1. Stem Cell Res. 2023 71: 103141. https://www.sciencedirect.com/science/article/pii/S1873506123001277

2022

30. Anne A, Kumar L, Salavadi RK, Anand PS, Nuguri S, Bindra S, Reddy KVR, Gummanur MR, Mohan KN^* Somatic Variants and Exon-Level Copy Number Changes in Five Hyperplastic Oral Leukoplakias. Cytogent. Genome Res. 2022 162: 560-569. https://karger.com/cgr/article-abstract/162/10/560/836047/Somatic-Variants-and-Exon-Level-Copy-Number?redirectedFrom=fulltext

29. Anne A, Bindra S, Reddy KVR, Gummanur MR, Mohan KN^* Comparative Somatic Variant Analysis of a Rare Case with Concurrent Oral Leukoplakia and Oral Submucosal Fibrosis. Cytogenet. Genome Res. 2022 162: 207-213. https://karger.com/cgr/article-abstract/162/4/207/822002/Comparative-Somatic-Variant-Analysis-of-a-Rare?redirectedFrom=fulltext

28. Anne A, Saxena S, Mohan KN^* Genome-wide methylation analysis of post-mortem cerebellum samples supports the role of peroxisomes in autism spectrum disorder. Epigenomics 2022 14: 1015-1027. https://www.tandfonline.com/doi/abs/10.2217/epi-2022-0184

27. Mohan KN^*DNMT1: catalytic and non-catalytic roles in different biological processes. Epigenomics 2022 14: 629-643. https://www.tandfonline.com/doi/full/10.2217/epi-2022-0035

2021

26. Choudhury S, Mohan KN^* Generation of a transgenic mouse embryonic stem cell line expressing Dnmt1Y495C mutation associated with HSAN1E disorder. Stem Cell Res. 2021 56:102561. https://www.sciencedirect.com/science/article/pii/S1873506121004086

25. Saxena S, Choudhury S, Maroju PA, Anne A, Kumar L, Mohan KN^*. Dysregulation of schizophrenia-associated genes and genome-wide hypomethylation in neurons overexpressing DNMT1. Epigenomics 2021 19: 1539-1555. https://www.tandfonline.com/doi/full/10.2217/epi-2021-0133

24. Saxena S, Maroju PA, Choudhury S, Voina VC, Naik P, Gowdhaman K, Kkani P, Chennoju K, Srinivasan GK, Chellamuthu R, Gundugurthi PR, Jamma T, Narayan KP, Mohan KN*. Functional analysis of Dnmt1 SNPs (rs2228611 and rs2114724) associated with schizophrenia. Genetics Research 2021 2021:6698979. https://onlinelibrary.wiley.com/doi/full/10.1155/2021/6698979

2020

23. Saxena S, Choudhury S, Mohan KN^*. Reproducible differentiation and characterization of neurons from mouse embryonic stem cells. MethodsX 2020 7:101073. https://www.sciencedirect.com/science/article/pii/S2215016120302934

22. Saxena S, Choudhury S, Mohan KN^*. Genome-wide methylation data from R1 (Wild-type) and the transgenic Dnmt1^tet/tet mouse embryonic stem cells overexpressing DNA methyltransferase 1 (DNMT1). Data in Brief 2020 32:106242. https://www.sciencedirect.com/science/article/pii/S2352340920311367?via%3Dihub

21. Saxena S, Maroju PA, Choudhury S, Anne A, Mohan KN^*. Analysis of transcript levels of a few schizophrenia candidate genes in neurons from a transgenic mouse embryonic stem cell model overexpressing DNMT1. Gene 2020 757:144934. https://www.sciencedirect.com/science/article/pii/S037811192030603X?via%3Dihub

20. Addepalli A, Kalyani S, Singh M, Bandyopadhyay D, Mohan KN^*. CalPen (Calculator of Penetrance), a web-based tool to estimate the penetrance in complex genetic disorders. PLoS One. 2020 (15): e0228156. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228156

2019

19. Saxena S, Kkani P, Ramasubramanian C, Kumar SG, Monisha R, Prasad Rao G, Mohan KN^*. Analysis of 15q11.2 CNVs in an Indian population with schizophrenia. Ann Hum Genet. 2019 83: 187-191. https://onlinelibrary.wiley.com/doi/10.1111/ahg.12300

18. Mohan KN^*, Cao Y, Pham J, Cheung SW, Hoffner L, Ou ZZ, Surti U, Cook EH, Beaudet AL. Phenotypic association of 15q11.2 CNVs of the region of breakpoints 1-2 (BP1-BP2) in a large cohort of samples referred for genetic diagnosis. J Hum Genet. 2019 64: 253-255. https://www.nature.com/articles/s10038-018-0543-7

2017

17. Ajit S, Praveen HM, Puneeth SB, Dave A, Sesham B, Mohan KN, Goel S. Towards rapid prototyped convective microfluidic DNA amplification platform. Microfluidics, BioMEMS and Medical Microsystems 2017 XV 10061, 100610H. https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10061/100610H/Towards-rapid-prototyped-convective-microfluidic-DNA-amplification-platform/10.1117/12.2257843.short

2016

16. Mohan KN^*. Stem Cell Models to Investigate the Role of DNA Methylation Machinery in Development of Neuropsychiatric Disorders. Stem Cells International. 2016;2016:4379425. https://onlinelibrary.wiley.com/doi/10.1155/2016/4379425

2015

15. Saxena S, Gowdhaman K, Kkani P, Vennapusa B, Rama Subramanian C, Ganesh Kumar S, Mohan KN^*. Improved Multiplex Ligation-dependent Probe Amplification (i-MLPA) for rapid copy number variant (CNV) detection. Clinica Chimica Acta. 2015 Oct 23;450:19-24. https://www.sciencedirect.com/science/article/pii/S0009898115003575

14. McGraw S, Zhang JX, Farag M, Chan D, Caron M, Konermann C, Oakes CC, Mohan KN, Plass C, Pastinen T, Bourque G, Chaillet JR, Trasler JM. Transient DNMT1 suppression reveals hidden heritable marks in the genome. Nucleic Acids Res. 2015 43:1485-1497. https://academic.oup.com/nar/article/43/3/1485/2411302?login=false

2014

13. Chaste P, Sanders SJ, Mohan KN, Klei L, Song Y, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Martin DM, Morrow EM, Walsh CA, Sutcliffe JS, State MW, Martin CL, Devlin B, Beaudet AL, Cook EH Jr, Kim SJ. Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2. Autism Res. 2014 Jun; 7(3):355-362. https://onlinelibrary.wiley.com/doi/full/10.1002/aur.1378

2013

12. Szafranski P, Dharmadhikari AV, Brosens E, Gurha P, Kolodziejska KE, Zhishuo O, Dittwald P, Majewski T, Mohan KN, Chen B, Person RE, Tibboel D, de Klein A, Pinner J, Chopra M, Malcolm G, Peters G, Arbuckle S, Guiang SF 3rd, Hustead VA, Jessurun J, Hirsch R, Witte DP, Maystadt I, Sebire N, Fisher R, Langston C, Sen P, Stankiewicz P. Small noncoding differentially methylated copy-number variants, including lncRNA genes, cause a lethal lung developmental disorder. Genome Res. 2013 Jan; 23(1):23-33. https://genome.cshlp.org/content/23/1/23.long

Before Joining BITS Pilani

2011

11. Bird LM, Tan WH, Bacino CA, Peters SU, Skinner SA, Anselm I, Barbieri-Welge R, Bauer-Carlin A, Gentile JK, Glaze DG, Horowitz LT, Mohan KN, Nespeca MP, Sahoo T, Sarco D, Waisbren SE, Beaudet AL. A therapeutic trial of pro-methylation dietary supplements in Angelman syndrome. Am J Med Genet A. 2011 Dec;155A(12):2956-2963. https://onlinelibrary.wiley.com/doi/10.1002/ajmg.a.34297

10. D'Aiuto L, Di Maio R, Mohan KN⁺, Minervini C, Saporiti F, Soreca I, Greenamyre JT, Chaillet JR. Mouse ES cells overexpressing DNMT1 produce abnormal neurons with upregulated NMDA/NR1 subunit. Differentiation. 2011 Jul;82(1):9-17. (Joint first Author) https://www.sciencedirect.com/science/article/pii/S0301468111000557?via%3Dihub

09. Mohan KN, Ding F, Chaillet JR. Distinct roles of DMAP1 in mouse development. Mol Cell Biol. 2011 May;31(9):1861-1869. https://www.tandfonline.com/doi/10.1128/MCB.01390-10?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

08. Mohan KN^*, Rani BS, Kulashreshta PS, Kadandale JS. Characterization of TTAGG telomeric repeats, their interstitital occurrence and constitutively active telomerase in the mealybug Planococcus lilacinus (Homoptera, Coccoidea). Chromosoma 2011 120: 165-175. https://link.springer.com/article/10.1007/s00412-010-0299-0

07. Rugo RE, Mutamba JT, Mohan KN, Yee T, Chaillet JR, Greenberger JS, Engelward BP. Methyltransferases mediated cell memory of a genotoxic insult. Oncogene 2011 30: 751-756. https://www.nature.com/articles/onc2010480

2010

06. D’Aiuto L, Marzulli M, Mohan KN, Borowzczyk E, Saporiti F, Vandemark A, Chaillet JR. Dissection of structure and function of the N-terminal domain of mouse DNMT1 using regional frame-shift mutagenesis. PLoS One 2010 23: e9831. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0009831

2009

05. Borowczyk E, Mohan KN⁺, D'Aiuto L, Cirio MC, Chaillet JR. Identification of a region of the DNMT1 methyltransferase that regulates the maintenance of genomic imprints. Proc Natl Acad Sci U S A. 2009 Dec 8;106(49): 20806-20811. (Joint First Author) https://www.pnas.org/doi/10.1073/pnas.0905668106?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed

2007

04. Mohan KN^*, Rani BS, Selvam S, Debarshi S, Kadandale JS. Comparison of mealybug (Planococcus lilcinus) and fruit fly genomes: Isolation and analysis of conserved sequences and their utility in studying synteny in the mealybug. Cytogenet Genome Res. 2007 119: 255-262. https://karger.com/cgr/article-abstract/119/3-4/255/61710/Comparison-of-mealybug-Planococcus-lilacinus-and?redirectedFrom=fulltext

2005

03. Mohan KN^*, Chandra HS. Isolation and analysis of sequences showing sex-sepcific cytosine methylation in the mealybug Planococcus lilacinus. Mol Genet Genomics 2005 274: 557-568. https://link.springer.com/article/10.1007/s00438-005-0004-9

02. Pal D, Venkataraman V, Mohan KN, Chandra H.S, Natarajan V. A power-efficient thermocycler based on induction heating for DNA amplification by polymerase chain reaction. Review of Scientific Instruments 2005; 75(9): 2880-2883. https://pubs.aip.org/aip/rsi/article-abstract/75/9/2880/351822/A-power-efficient-thermocycler-based-on-induction?redirectedFrom=fulltext

2002

01. Mohan KN, Ray P, Chandra HS. Characterization of the genome of the mealybug Planococcus lilcainus, a model organism for studying whole-chromosome imprinting and inactivation. Genet Res. 2002 79: 111-118. https://www.cambridge.org/core/journals/genetics-research/article/characterization-of-the-genome-of-the-mealybug-planococcus-lilacinus-a-model-organism-for-studying-wholechromosome-imprinting-and-inactivation/B20A33FC575CF0B05BC7C2D6E0165963

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