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Dr. Aditya Sharma

Assistant Professor, Department of Biotechnology

Bioinformatics and Computational Biology, Computer Aided Drug Design, Next Generation Sequencing data analysis (WES), computational chemistry/cheminformatics, computational genomics, genetic disorders (Mendelian and complex), human genetics
Room No. 317, BITS Pilani, Dubai Campus Dubai International Academic City P.O. Box No. – 345055, Dubai, UAE

Research Focus

My research work involves novel drug target identification and development of lead molecules using computational approaches for complex genetic disorders in humans, with a special focus on neurodegenerative and neurodevelopmental disorders such as Parkinson’s, Alzheimer's, dementia and schizophrenia. These disorders are responsible for significant global disease burden compounded by various factors like increasingly longer lifespans, social stigma, lack of awareness and access to adequate specialised support structures and therapy. Treatment remains largely symptomatic, and disease modifying therapies which delay or halt progression are the need of the hour. A key aspect to developing such therapeutics is finding novel drug targets for these disorders through identification of potentially novel mechanisms and pathways which may have a direct or indirect role in the pathophysiology of these diseases. These genes can then be assessed for their suitability as drug targets, and a three-pronged computational drug discovery approach can be then utilised to design and/or discover novel lead molecules targeting them. This approach can also be supplemented with repurposing of drugs approved for related conditions and/or targets. 

  • Ongoing research project – “Leveraging computational genomics for novel drug target discovery and lead molecule development for neurological disorders". 

Interested PhD aspirants or UG/PG students looking for internship with an interest in this area may contact through appropriate communication channels.