Senior Professor, Department of Pharmacy,
Dean, Administration
Shri B.K. Birla and Smt. Sarala Birla Chair Professor
Chairperson, Institutional Animal Ethics Committee
· Journal of Medicinal Chemistry (ACS, USA)
· Journal of Chemical Information & Modeling (ACS, USA)
· European Journal of Medicinal Chemistry (Elsevier)
· Bioorganic Medicinal Chemistry (Elsevier)
· Drug Discovery Today (Elsevier)
· Recent Patents on CNS Drug Discovery (Bentham)
· Current Enzyme Inhibition (Bentham)
· Acta Pharmacologica Sinica (Blackwell Publishing)
· Brain Research (Elsevier)
· International Journal of Biomedical Science (Master Publishing group, USA)
· Archive der Pharmazie (Wiley VCH)
· European Journal of Pain (Elsevier)
· Brain Research (Elsevier)
· Medicinal Research Reviews (Wiley)
· Expert Opinion on Drug Discovery (Informa Health)
· Expert Opinion on Drug Safety (Informa Health)
· Archive der Pharmazie (Wiley)
· Various New Targets of Neurological disorders that include
i. Neuropathic pain including Diabetic neuropathy
ii. Autism spectrum disorder (ASD)
iii. Fragile X syndrome
iv. Fetal Alcohol spectrum disorder (FASD)
v. Duchenne Muscular Dystrophy
vi. Epilepsy,
vii. Alzheimer’s Disease,
· Various New Targets for
i. Tuberculosis
ii. Hepatitis C virus
iii. Dengue virus
iv. Cancer
Drug Screening
i. Anticonvulsant screening
ii. Neuropathicpain
iii. CNS Behavioral and cognition screening
iv. Neurochemical estimations in different regions of brain
v. Nerve conduction velocity
vi. Anti-Cancer screening
vii. Anti-inflammatory screening
viii. Neurotoxicity screening
ix. Molecular pharmacology
x. Biophysical characterization
Research Collaborations
· National Institute of Health, Bethesda, USA
· National Cancer Institute, USA
· National Institute of Mental Health and Neurosciences, Bangalore, India
· Indian Institute of Science, Bangalore, India.
· National Institute of Immunology, New Delhi, India
· Karolinska Institute, Stockholm, Sweden
· The University of Queensland, Australia
· Department of Ophthalmology & Visual Science, University of Illinois, Chicago, USA
· Dongduk Women's University, Seoul, Korea
· Pasteur Institute, University of Lille, France
· University of KwaZulu Natal, Durban, South Africa
· Federal University of Para, Belem, Brazil
· Bogomoletz Institute of Physiology National Academy of Science, Ukraine
· Faculty of Medicine of Porto, Porto, Portugal
· Instituto Nacional de Ciencia e Technologia em Tuberculosis, MCT/CNPq, Porto Alegre, Brazil
· Incozen Therapeutics Pvt. Ltd, Hyderabad
· Rutger's The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA
· Basavatarakam Indo-US Cancer Hospital, Hyderabad, India
· Army College of Dental Sciences, Hyderabad
BOOKS & Chapters in BOOK
1. D. Sriram, P. Yogeeswari, Textbook on Medicinal Chemistry, 2e, 2010, Pearson Education Singapore Ltd.
2. Book Chapter: P. Yogeeswari and D. Sriram, SUSTAINABILITY IN HIGHER EDUCATION THROUGH BASIC SCIENCE RESEARCH -STRATEGIES FOR CORPORATE BODIES IN PHARMACEUTICALS in Evolving Corporate Education Strategies for Developing Countries: The Role of Universities, Released in Jan 2013 by IGI Global- Officially released by the Hon'ble Minister of Human Resources Development , Government of India, SRI PALLAM RAJU in May 2013
3. Book Chapter: P. Purkayastha, A. Rallapalli, N.L. Bhanu Murthy, A. Malapati, P. Yogeeswari, D. Sriram, EFFECT OF FEATURE SELECTION ON KINASE CLASSIFICATION MODELS in Computational Intelligence in Medicial Informatics, Springer Singapore, 2015.
4. Book Chapter: P. Purkayatha, S. Varanasi, A. Malapati, P. Yogeeswari, D. Sriram, EFFECT OF PHYSIOCHEMICAL PROPERTIES ON CLASSIFICATION ALGORITHMS FOR KINASES FAMILY in Chapter COMPUTATIONAL INTELLIGENCE IN DATA MINING- Volume 2, Volume 411 of the Series Advances in Intelligent Systems and Computing Series, Springer, 2016, pp 47-57.
PATENTS:
1. Yogeeswari, P.,Sriram, D., Kumar, A.S.K. et al., Novel N-Spiro substituted compounds. Indian Patent 263536 (Granted on 5th Nov 2014)
2. Yogeeswari, P., Sriram, D., Madhubabu, B., Brahmam, M., Indian Patent Application No. 2945/DEL/2014 (15/10/2014): A Compound for treating inflammatory neuropathic pain and cancer.
3. Saketh, D.V.S., Srikanth, V., Yogeeswari, P., Sriram, D., Indian Patent Application No. 5707/CHE/2014 (13/11/2014): Novel compounds as modulators of AKT.
4. Yogeeswari, P., Sriram, D., Hasitha, S.A., Brahmam, M., Indian Patent Application No. 1763/DEL/2015 (12/06/2015): Cathepsin D inhibitors and compositions thereof for treating breast cancer.
5. Vinay K. Nadicoori, Vijay S., Yogeeswari, P., Sriram, D., Indian Patent Application No. 3167/DEL/2015 (01/10/2015): Novel compounds with antitubercular potential.
6. Yogeeswari, P., Parameshwar Reddy, A., Dwivedi, S. Indian Patent Application No. E-136359/2019-DEL (28/08/2019): Compounds for the treatment of inflammation and process for preparing the same.
CRYSTAL STRUCTURES:
Crystal Structures of the Ligand Designed in our CADD lab published in pdb.
1. 3ZEI: Structure of the Mycobacterium tuberculosis O-Acetylserine Sulfhydrylase (OASS) CysK1 in complex with a small molecule inhibitor5AKWCrystal structure of TNKS2 in complex with 2-(4-chlorophenyl)-1,2,3,4- tetrahydroquinazolin-4-oneCrystal structure of TNKS2 in complex with 2-(4-(propan-2-yl)phenyl)- 1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one
2. Structure of the Mycobacterium tuberculosis O-Acetylserine Sulfhydrylase (OASS) CysK1 in complex with a small molecule inhibitor5AKWCrystal structure of TNKS2 in complex with 2-(4-chlorophenyl)-1,2,3,4- tetrahydroquinazolin-4-oneCrystal structure of TNKS2 in complex with 2-(4-(propan-2-yl)phenyl)- 1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one: Structure of the Mycobacterium tuberculosis O-Acetylserine Sulfhydrylase (OASS) CysK1 in complex with a small molecule inhibitor5AKWCrystal structure of TNKS2 in complex with 2-(4-chlorophenyl)-1,2,3,4- tetrahydroquinazolin-4-oneCrystal structure of TNKS2 in complex with 2-(4-(propan-2-yl)phenyl)- 1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one
3. 5AL1: Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1H, 2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one
4. 5AL2: Structure of the Mycobacterium tuberculosis O-Acetylserine Sulfhydrylase (OASS) CysK1 in complex with a small molecule inhibitor5AKWCrystal structure of TNKS2 in complex with 2-(4-chlorophenyl)-1,2,3,4- tetrahydroquinazolin-4-oneCrystal structure of TNKS2 in complex with 2-(4-(propan-2-yl)phenyl)- 1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one
5. 5AL3: Crystal structure of TNKS2 in complex with 2-(2,4-dichlorophenyl)-1- methyl-1H,2H,3H,4H-pyrido(2,3-d)pyrimidin-4-one
6. 5AKU: Crystal structure of TNKS2 in complex with 2-(4-tert-butylphenyl)-1,2, 3,4-tetrahydroquinazolin-4-one
7. 5AL4: Crystal structure of TNKS2 in complex with 2-(4-methylpiperazin-1-yl)- 3,4,5,6,7,8-hexahydroquinazolin-4-one
8. 5AL5: Crystal structure of TNKS2 in complex with 2-(4-((pyridin-4-yl)methyl) piperazin-1-yl)-3,4,5,6,7,8-hexahydroquinazolin-4-one
Click here for more information.
Completed Projects
1. DST Fast Track for young scientist- DESIGN OF NEW ANTICONVULSANTS: SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF ARYL SEMICARBAZONES AND ITS ANALOGUES- 2004-2007| Principal Investigator
2. CSIR project - SYNTHESIS AND NEUROPHARMACOLOGY OF 4-AMINOBUTYRIC ACID ANALOGUES-2006-2009| Principal Investigator
3. CSIR project- DEVELOPMENT OF NEW GENERATION QUINOLONE MOLECULES AGAINST MYCOBACTERIUM TUBERCULOSIS- 2005-2008|Co-Investigator
4. UGC Major project-DESIGN AND SYNTHESIS OF NEWER GABA ANALOGUES FOR TREATING CNS DISORDERS- 2007-2010|Principal Investigator
5. ICMR project-DESIGN AND SYNTHESIS OF NOVEL NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS FOR THE TREATMENT OF AIDS AND OPPORTUNISTIC INFECTIONS ASSOCIATED WITH AIDS INCLUDING TUBERCULOSIS TUBERCULOSIS -2005-2008|Co-Investigator
6. OPEN SOURCE DRUG DISCOVERY (CSIR) Project-DESIGN AND SYNTHESIS OF NEW INBIBITORS OF MTB GLMU BY MODELING & HIGH THROUGHPUT DOCKING -2010-2011|Co-Investigator.
7. DBT CENTRE OF EXCELLENCE PROJECT- VIRTUAL CENTRE OF EXCELLENCE FOR TUBERCULOSIS RESEARCH (In collaboration with Indian Institute of Science, Bangalore & The Foundation for Medicial Research, Mumbai)-2007-2012|Co-Investigator
8. UGC Major project-ISOCITRATE LYASE ENZYME AS TARGET IN PERSISTENT MYCOBACTERIUM TUBERCULOSIS INFECTION: SYNTHESIS OF 2-ARYLTHIAZOLIDINE-4-CARBOXYLIC ACID AND 5-NITRO-2-FUROIC ACID DERIVATIVES AND ITS ANTIMYCOBACTERIAL EVALUATION-2009-2012|Co-Investigator
9. CSIR project- DEVELOPMENT OF NOVEL DNA GYRASE INHIBITORS AGAINST MYCOBACTERIUM TUBERCULOSIS AND OTHER NON-TUBERCULOSIS MYCOBACTERIAL INFECTIONS -2010-2013|Co-Investigator
10. DBT Neuroresearch Project- STRUCTURE-GUIDED DESIGN OF NOVEL NON-PEPTIDIC NONCOVALENT SELECTIVE INHIBITORS OF THE SPINAL MICROGLIAL CATHEPSIN S FOR THE TREATMENT OF NEUROPATHIC PAIN-2011-2013| Principal Investigator
11. DST Project- STRUCTURE-BASED RATIONAL DESIGN AND SYNTHEIS OF MYCOBACTERIUM TUBERCULOSIS PANTOTHENATE SYNTHETASE INHIBITORS-2011-2014| Co-Investigator
12. DST INDO-BRAZILIAN_SOUTH AFRICAN-DEVELOPMENT, SYNTHESIS, AND TESTING OF NOVEL ANTI-HIV DRUGS-2011-2014| Co-Investigator
13. DBT Project- DISCOVERY OF NOVEL MODULATORS OF NAD(+) DEPENDENT PROTEIN DEACETYLASE SIRT1 FOR THE TREATMENT OF VARIOUS HUMAN DISORDERS -2011-2014|Principal Investigator
14. CSIR project- DESIGN AND SYNTHESIS OF PHARMACOPHORIC HYBRIDS AS POTENTIAL LEADS FOR THE TREATMENT OF NEUROPATHIC PAIN-2012-2015|Principal Investigator
15. DBT INDO-SWEDEN Project-STRUCTURE-GUIDED DESIGN OF NEW ANTIBACTERIAL AGENTS AGAINST DORMANT MYCOBACTERIUM TUBERCULOSIS-2009-2014 |Co-Investigator
16. ICMR project- DEVELOPMENT OF DRUGS FOR THE TREATMENT OF LATENT PHASE OF TUBERCULOSIS- 2011-2014| Co-Investigator
17. DST Major Research Project- DRUG DISCOVERY OF INHIBITORS OF THE PROTEASE OF PERIPHERAL MACROPHAGES AND MICROGLIAL CELLS IN THE SPINAL CORD FOR THE TREATMENT OF NEUROPATHIC PAIN- 2011-2015| Principal Investigator.
18. DST INDO-UKRAINE JOINT PROJECT-DEVELOPMENT OF ANTIEPILEPTIC LEADS TO SUPPRESS HIPPOCAMPAL EPILEPTIC SEIZURES-2012-2015|Principal Investigator.
19. DBT RGYI project-NON-INVASIVE DELIVERY OF siRNA TO TREAT MELANOMA-2012-2015|Co-Investigator
20. OPEN SOURCE DRUG DISCOVERY-CSIR-DEVELOPMENT AND ANALYSIS OF NOVEL INHIBITORS AGAINST MTB GlmU- 2012-2015| Co-Principal Investigator (In Collaboration with NII, New Delhi, and IIT- Kanpur)
21. ICMR-INSERM (Indo-France) project- STRUCTURE-BASED DESIGN OF ORPHAN NUCLEAR RECEPTOR MODULATOR TO TREAT DIABETES AND ITS COMPLICATIONS BY TARGETING RORALPHA AND REV-ERBALPHA-2014-2016| Principal Investigator
22. DBT INDO-SWEDEN new project- STRATEGIES AGAINST ANTIBIOTIC RESISTANCE IN MYCOBACTERIUM TUBERCULOSIS AND PSEUDOMONAS AERUGINOSA: NEW DRUG FOR OLD TARGETS AND OLD DRUGS FOR NEW TARGETS- 2014-2017|Co-Investigator
23. DST INDO-PORTUGAL project- DEVELOPMENT OF NOVEL COMPOUNDS FOR THE TREATMENT OF NEURAL COMPLICATIONS OF DIABETES-2014-2017| Principal Investigator
24. DBT INDO-BRAZIL project - ENZYMES FROM PURINE AND PYRIMIDINE BIO-SYNTHETIC PATHWAY AS TARGETS FOR THE DEVELOPMENT OF MYCOBACTERIUM TUBERCULOSIS DRUGS-2014-2017| Principal Investigator
25. DST INDO-POLISH project- MYCOBACTERIAL TUBERCULOSIS ACETYL COENZYME A CARBOXYLASE INHIBITORS: STRUCTURE-BASED DRUG DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION- Approved| Co-Investigator
Ongoing projects
Co-Investigator, DBT project entitled "MRI based non-invasive quantitative
biomarker for early diagnosis and prognosis of brain tumor"- In Collaboration with EEE/ECE Department, BITS Pilani, Hyderabad campus
Industry sponsored projects
1. ASTRA ZENCA, Bangalore- Development of New Antitubercular agents-2010-2013(COMPLETED)
2. ADITYA BIRLA GROUP, Mumbai- Structure-based rational design and synthesis of inhibitors of various enzymes Mycobacterium tuberculosis - 2011-2014 (COMPLETED)
3. Incozen Therapeutics Ltd, Hyderabad - Development of Novel Antiinflammatory Agents-2012-2015 (COMPLETED)
Research Students
B.Pharm Projects guided: 150
B.Pharm thesis guided: 9
B.E. projects guided: 10
M.Pharm projects guided: 55
M.Pharm dissertation guided:7
Ph.D. Students Details:
Completed: 21
1. Dr. Shalini Mehta on “SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF NEW ARYL AND HETEROARYL SEMICARBAZONES AS ANTICONVULSANTS”- Completed in 2007. (Current position: Works at FDA & F. Hoffmann La Roche AG, USA)
2. Dr. J.Vaigunda Raghavendran on "DESIGN OF GABA ANALOGUES AS ANTICONVULSANTS - SYNTHESIS & NEUROPHARMACOLOGY"- Completed in 2008. (Current position: Scientific Medical Writer, Ogilvy CommonHealth Worldwide, Montreal, Canada)
3. Dr. A.S.K. Reddy on "SYNTHESIS AND NEUROPHARMACOLOGY OF 4-AMINOBUTYRIC ACID ANALOGUES"- Completed in 2009. (Current position: Scientist at Aurobindo Pharma, Hyderabad, India)
4. Dr. Arvind Semwal on "PHARMACOLOGICAL INTERVENTIONS TO IDENTIFY POTENTIAL DRUG CANDIDATES FOR THE TREATMENT OF NEUROPATHIC PAIN"- Completed in 2012 (Current position: senior Manager, Medical Writing, Parexel International, Hyderabad, India)
5. Dr. Pritesh Bhat on “DESIGN OF VARIOUS NEW ENZYME INHIBITORS AS ANTIMYCOBACTERIAL AGENTS USING IN-SILICO HIGH-THROUGHPUT SCREENING"- Completed in 2013. (Current position: Senior Applications Scientist at Schrodinger, Bangalore, India)
6. Dr. Monika Sharma on "DESIGN AND SYNTHESIS OF MULTIFUNCTIONAL LEADS FOR THE TREATMENT OF NEUROPATHIC PAIN"- Completed in 2013. (Current position: Postdoctoral Fellow, Nanyang Technical Universty (NTU), Singapore)
7. Dr. J.T. Patrisha on "PHARMACOPHORE MODELING AND 3D QSAR COMBINED WITH VIRTUAL SCREENING TO IDENTIFY NOVEL INHIBITORS OF PROTEIN TARGETS OF INFECTIOUS DISEASES"-Completed in 2015. (Current position: Entrepreneur, Trinity Groups, India)
8. Dr. Madhu Babu B on "DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL CATHEPSIN S INHIBITORS"- Completed in 2015. (Current position: Entrepreneur- Started a Diagnostic Centre)
9. Dr. Saketh Sriram on "STRUCTURE-BASED DESIGN AND SYNTHESIS OF NOVEL AKT INHIBITORS FOR PRECLINICAL EVALUATION IN LUNG CANCER CELL LINES"-Completed in 2015.(Current position: PostDoc, Penn State College of Medicine, Hershey, PA)
10. Dr. P. Brindha Devi on "DEVELOPMENT OF NOVEL PANTOTHENATE SYNTHETASE AND LYSINE AMINOTRANSFERASE INHIBITORS AGAINST ACTIVE AND DORMANT TUBERCULOSIS"- Completed in 2015.(Current position: Assistant Professor, Department of Bio-Engineering, Vels Institute of Science, Technology and Advanced Studies, Chennai, India)
11. Dr. Ram Kumar Mishra on "DESIGN AND CHARACTERIZATION OF NOVEL PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF NEURONAL COMPLICATIONS OF DIABETES"- Completed in 2015. (Current position: Project Analyst, ICON PLC, Bangalore, India)
12. Dr. Reshma Chowdhary on "DUAL INHIBITORS OF ROCK-I AND NOX2 TO ATTENUATE NEUROINFLAMMATION IN NEUROLOGICAL DISORDERS: HIGH THROUGHPUT VIRTUAL ND BIOLOGICAL SCREENING"- Completed in 2015. (Current position: Research Associate, Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad, India)
13. Dr. Venkat Koushik (CSIR SRF) on "TARGETING SIRT1 AND ITS PATHWAY FOR THERAPEUTIC INTERVENTION OF CANCER: DRUG DESIGN AND BIOLOGICAL EVALUATION"- Completed in March 2016 (Current position: Senior Product Manager, Merck Group Bangalore, India)
14. Dr. Brahmam Medapi (ICMR SRF) on DEVELOPMENT OF NOVEL QUINOLINE ANALOGUES AS MYCOBACTERIUM TUBERCULOSIS DNA GYRASE INHIBITORS- Completed in June 2016. (Current Position: Associate Scientist, GVKBio, Bangalore, India)
15. Dr. Priyanka S on "COMPUTATIONAL ANALYSES OF MYCOBACTERIUM TUBERCULOSIS ENZYME INHIBITORS: A STUDY INVOLVING FREE ENERGY PERTURBATION AND MOLECULAR DYNAMICS SIMULATIONS"-Completed in Dec 2016. (Current Position: Post Doctoral Scientist, University of Kentucky)
16. Dr. Srikant Racharla on DESIGN, SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF NOVEL ADENOSINE A2 MODULATORS FOR TREATMENT OF EPILEPSY AND PAIN- Completed in September 2016. (Current Position: Research Associate, Hospira, Pfizer company, Chennai)
17. Dr. Hasitha S Anantharaju (DST INSPIRE Fellow) on CATHEPSIN D, AN ASPARTATE PROTEASE AS A POTENT THERAPEUTIC OPTION FOR BREAST CANCER: DESIGN, SYNTHESIS AND BIOEVALUATION AGAINST TRIPLE POSITIVE AND TRIPLE NEGATIVE BREAST CANCERS- Completed in October 2017. (Current Position: Scientific Writer II, Novartis, Hyderabad, India)
18. Dr. M. Gangadhar on "MOLECULAR PHARMACOLOGICAL INVESTIGATIONS ON NEW CHEMICAL ENTITIES USEFUL IN THE TREATMENT OF NEUROPATHIC PAIN - Completed in Feb 2018 (Current Position: Senior Research Associate, GVK EXCELRA, Hyderabad)
19. Dr. Pushkar Kulkarni (ILS, Hyderabad) on "ZEBRA FISH MODELS FOR NEUROSCIENCE DRUG DISCOVERY -Completed in June 2018 (Current Position: Dr. Reddy's Institute of Life Sciences, University of Hyderabad campus, Hyderabad)
20. Mr. Shubham Diwedi (DBT JRF, BITS Scholar, ICMR SRF) on DEVELOPMENT, VALIDATION, AND EXPLORATION OF NOVEL DISEASE MODELS FOR AUTISM, Completed in December 2019 Current Position: Assistant Professor, University of Petroleum and Energy Studies, Uttarkhand )
21. Mr. Parameshwar Reddy (AMRI, Hyderabad) on SYNTHESIS OF NOVEL LEADS USEFUL FOR NEUROLOGICAL DISEASES, Completed in September 2021
Presently Guiding: 4
Ms. Purbali Chakraborty (ICMR SRF) on DRUG DISCOVERY FOR ORAL CANCER
Ms. Dipika Sahu on DRUG DISCOVERY FOR COLORECTAL CANCER
Ms. Deepika (ICMR JRF) on NEUROPHARMACOLOGICAL INTERVENTION FOR PAIN THERAPEUTICS
Mr. Madan (Almelo Industry) on DRUG SYNTHESIS FOR CANCER RESEARCH