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Dr. Hemant R. Jadhav

pilani Pharmacy

Professor, Department of Pharmacy,
BITS Pilani, Pilani Campus

Pharmaceutical Chemistry
Department of Pharmacy, Birla Institute of Technology & Science, Pilani- 333031, Rajasthan. India.
hemantrj@pilani.bits-pilani.ac.in
+91 (1596) 255506 | +91-94140-82744
https://www.linkedin.com/in/hemantrjadhav

Publications

  1. Sangeeta Hazarika, Shikha Thakur, Hemant R. Jadhav, Pankaj Chetia, Damiki Laloo, Siva Hemalatha (2024). ‘Investigation of antibacterial potential of Natsiatum herpeticum Buch.-Ham. ex Arn. using in silico-in vitro approach’, South African Journal of Botany, Elsevier, 164, 167-179. IF: 3.1. doi: 10.1016/j.sajb.2023.11.041
  2. Amit Sharma, Hemant R. Jadhav, Anubhav Rai, Naga Rajiv Lakkaniga, Harish C. Chandramoorthy, Hossam Mohammed Kamli, Mohammad Y. Alshahrani, and Prasanna Rajagopalan (2023). ‘A Comprehensive Review of Systemic Targeted Therapies in Cancer Treatment’, Current Cancer Therapy Reviews, Bentham Science, IF: 0.6. doi: 10.2174/0115733947261058231017170056.
  3. Amit Sharma, Santosh Rudrawar, and Hemant R. Jadhav (2023). ‘Butadiene Sulfone-catalyzed Monobromination of Arenes with NBS as the Bromination Source: A Simple, Mild, Efficient, and Chemoselective Protocol’, Letters in Organic Chemistry, Bentham Science, 21 (2), 201 – 208. IF: 1.0. doi: 10.2174/1570178620666230914164247
  4. Pinky Vishwakarma, Noor Fatima Siddiqui, Shikha Thakur & Hemant Jadhav (2023). ‘FDA approved fused-pyrimidines as potential PI3K inhibitors: a computational repurposing approach’, Journal of Biomolecular Structure and Dynamics, Taylor and Francis online. IF: 4.4. doi: 10.1080/07391102.2023.2276315.
  5. Abhishek Wahi, Namish Manchanda, Priti Jain, Hemant R Jadhav (2023). ‘Targeting the epigenetic reader “BET” as a therapeutic strategy for cancer’, Bioorganic Chemistry, 140, 106833. IF: 5.307. doi: 10.1016/j.bioorg.2023.106833.
  6. Abhishek Wahi, Priti Jain, Apurba Sinhari, Hemant R Jadhav (2023). 'Progress in discovery and development of natural inhibitors of histone deacetylases (HDACs) as anti-cancer agents', Naunyn-Schmiedeberg's Archives of Pharmacology, 1-28. IF: 3.6. doi: 10.1007/s00210-023-02674-4.
  7. Mohit Sharma, Ankita Sharma, Shikha Thakur, Vijay K Nuthakki, Ashiya Jamwal, Utpal Nandi, Hemant R Jadhav, and Sandip B Bharate (2023). 'Discovery of blood-brain barrier permeable and orally bioavailable caffeine-based amide derivatives as acetylcholinesterase inhibitors,' Bioorganic Chemistry, 139, 106719. IF: 5.307. doi: 10.1016/j.bioorg.2023.106719.
  8. Mohit Sharma, Shikha Thakur, Hemant R. Jadhav, and Sandip B. Bharate (2023). 'Identification of Azelastine and Carvedilol as Cholinesterase Inhibitors via Structure-Based Virtual Screening of FDA-approved Drugs,' ChemistrySelect, 8(28), e202301879. IF: 2.307. doi: 10.1002/slct.202301879.
  9. Subhash Chander, Shvetank Bhatt, Kamal Dua, and Hemant Jadhav (2023). 'Recent trends and spotlight on nucleotide-based drugs: novel targets, their design, delivery, and clinical potential,' Frontiers in Pharmacology, 14, 1245809. IF: 5.99. doi: 10.3389/fphar.2023.1245809.
  10. Mohd Abdullaha, Razia Banoo, Vijay K. Nuthakki, Mohit Sharma, Sukhleen Kaur, Shikha Thakur, Ajay Kumar, Hemant R. Jadhav, and Sandip B. Bharate (2023). 'Methoxy-naphthyl-Linked N-Benzyl Pyridinium Styryls as Dual Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Structure-Activity Relationship,' ACS Omega, 8, 20, 17591–17608. IF: 4.132. DOI: 10.1021/acsomega.2c08167.
  11. Vijay K. Nuthakki, Sushil Choudhary, Chilakala N. Reddy, Shipra Bhatt, Ashiya Jamwal, Anshika Jotshi, Rinky Raghuvanshi, Ankita Sharma, Shikha Thakur, Hemant R. Jadhav, Sonali S. Bharate, Utpal Nandi, Ajay Kumar, and Sandip B. Bharate (2023). 'Design, Synthesis, and Pharmacological Evaluation of Embelin–Aryl/alkyl Amine Hybrids as Orally Bioavailable Blood–Brain Barrier Permeable Multitargeted Agents with Therapeutic Potential in Alzheimer's Disease: Discovery of SB-1448,' ACS Chem. Neurosci., 14, 6, 1193–1219. IF: 5.78. DOI: 10.1021/acschemneuro.3c00030.
  12. Neha Dagar, Ajinath Kale, Hemant R. Jadhav, Anil Bhanudas Gaikwad (2023). 'Nutraceuticals and network pharmacology approach for acute kidney injury: A review from the drug discovery aspect,' Fitoterapia, 168, 105563. IF: 3.204. DOI: 10.1016/j.fitote.2023.105563.
  13. Shikha Thakur, Apurba Sinhari, Priti Jain, and Hemant R. Jadhav (2022). "A perspective on oligonucleotide therapy: Approaches to patient customization," Frontiers in Pharmacology, 12, 1006304. IF: 5.99. doi: 10.3389/fphar.2022.1006304
  14. Priti Jain, Pankaj K. Wadhwa, Hemant R. Jadhav (2021). "Design, Synthesis, and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitors: Plausible lead for Alzheimer's Disease", Medicinal Chemistry, 17 (10), 1194-1210. IF: 2.74. DOI: 10.2174/1573406417666201221155452
  15. Pankaj K. Wadhwa, Priti Jain, Hemant R. Jadhav (2021). "Design, Synthesis and in Vitro Evaluation of 4-Oxo-6-Substituted Phenyl-2-Thioxo1, 2, 3, 4-Tetrahydropyrimidine-5-Carbonitrile Derivatives as HIV Integrase Strand Transfer", Letters in Drug Design & Discovery, Bentham Science, 18 (4), 387-395. IF: 1.17, doi: 10.2174/1570180817999201022193325
  16. Vadiraj Kurdekar, Satish N. Dighe, and Hemant R. Jadhav (2020). "Study of arginine mimetic benzamidine urea derivatives as PAD4 inhibitors", Journal of the Indian Chemical Society, Elsevier, 97(8), 1273-1278. IF: 0.28. doi: 10.5281/zenodo.5656697
  17. Pankaj Wadhwa, Priti Jain, and Hemant R. Jadhav (2020). "Glycogen Synthase Kinase 3 (GSK3): Its Role and Inhibitors", Current Topics in Medicinal Chemistry, Bentham Science, 20 (17), 1563-1575. IF: 3.402, No. of Citations: 11 doi: 10.2174/1568026620666200516153136
  18. Pankaj Wadhwa, Priti Jain, and Hemant R. Jadhav (2020). "Synthesis and anti-HIV Evaluation of substituted Indole-3-carbaldehyde derivatives", Indian Drugs, IDMA, 57 (2), 18-26. IF: 0.07. doi: 10.53879/id.57.02.11912
  19. Pankaj Wadhwa, Priti Jain, and Hemant R. Jadhav (2020). "Design, Synthesis and In Vitro Evaluation of 2-Oxo-N-substituted phenyl 2H-chromene-3-carboxamide Derivatives as HIV Integrase Strand Transfer Inhibitors", Letters in Drug Design & Discovery, Bentham Science, 17 (4), 418-427. IF: 1.17 doi: 10.2174/1570180816666190617150803
  20. Pankaj Wadhwa, Priti Jain, Arpit Patel, Shantanu Shinde and Hemant R. Jadhav (2019). "Synthesis and Evaluation of 3-(1,3-dioxoisoindolin-2-yl)-N-substituted Phenyl Benzamide Analogues as HIV Integrase Strand Transfer Inhibitors", Anti-Infective Agents, Bentham Science, 17 (2), 105-114. IF: 0.16. doi: 10.2174/2211352516666181102121920
  21. Philip Ryan, Bhautikkumar Patel, Vivek Makwana, Hemant R. Jadhav, Milton Kiefel, Andrew Davey, Tristan A. Reekie, Santosh Rudrawar, and Michael Kassiou (2018). "Peptides, Peptidomimetics, and Carbohydrate−Peptide Conjugates as Amyloidogenic Aggregation Inhibitors for Alzheimer's Disease," ACS Chem. Neurosci., 9, 1530−1551, IF: 4.211, doi: 10.1021/acschemneuro.8b00185
  22. Mahaveer Singh, Hemant R. Jadhav (2018). "Targeting non-small cell lung cancer with small-molecule EGFR tyrosine kinase inhibitors," Drug Discovery Today, Elsevier, 23 (3), 745-753, IF: 6.691, No. of Citations: 96 DOI: 10.1016/j.drudis.2017.10.004
  23. Pankaj Wadhwa, Priti Jain, Santosh Rudrawar, Hemant R Jadhav (2018). "Quinoline, Coumarin, and Other Heterocyclic Analogs Based HIV-1 Integrase Inhibitors," Current drug discovery technologies, Bentham Science, 15 (1), 2-19, DOI: 10.2174/1570163814666170531115452
  24. Pankaj Wadhwa, Priti Jain, Sirish Cholasamudram and Hemant R Jadhav (2018). "Synthesis and Biological Evaluation of N-(4-Fluorophenyl)-6-Methyl-2-Oxo-1,2, 3, 4-Tetrahydropyrimidine-5-Carboxamides as HIV Integrase Strand Transfer Inhibitors", Der Pharmacia Lettre, 10 (4), 100-114.
  25. Mahaveer Singh, Hemant R. Jadhav, Amit Kumar (2018). "Design, Synthesis and in-vitro evaluation of piperazine incorporated novel anticancer agents," Letters in Drug Design and Discovery, Bentham Science, 15 (8): 866-574. IF: 1.17, DOI: 10.2174/1570180815666171211161501
  26. Mahaveer Singh, Hemant R. Jadhav, Tanya Bhatt (2017). "Dynamin Functions and Ligands: Classical Mechanisms Behind," Molecular Pharmacology, ASPET, 91 (2), 123-134. IF: 4.1, 33 DOI: 10.1124/mol.116.105064
  27. Pathak K, Mohanan A, Jadhav H, Acharya S, Mandavia D. (2016). "Exploring Visceral Adiposity Index as a predictor of visceral adiposity dysfunction and evaluating its performance in predicting hepatic insulin resistance in Indian type 2 diabetics", International Journal of Pharmacy and Pharmaceutical Sciences, 8(8):297-301
  28. Priti Jain, Pankaj K Wadhwa, Hemant R Jadhav (2016). "Design, synthesis, and evaluation of Acridin-9-yl hydrazide derivatives as BACE-1 inhibitors", Medicinal Chemistry Research, Bentham Science, 25(7): 1507-1513. IF: 1.402.
  29. Priti Jain, Pankaj K Wadhwa, Sinduri Gunapati, Hemant R Jadhav (2016). "Design, synthesis and in vitro evaluation studies of Sulfonyl-amino-acetamides as small molecule BACE-1 inhibitors", Bioorganic & Medicinal Chemistry, Elsevier, 24(11): 2567-75. IF: 2.793, DOI: 10.1016/j.bmc.2016.04.023
  30. Vandana Kharb, Vikas Anand Saharan, Vivek Kharb, Hemant Jadhav and Suresh Purohit (2016). "Formulation and characterization of taste masked ondansetron–magnesium aluminum silicate adsorption systems," Drug Development and Industrial Pharmacy, Taylor and Francis, 42 (8): 1291-1299. IF 2.101
  31. Priti Jain, Pankaj K Wadhwa, Shilpa Rohilla, Hemant R Jadhav (2016). "Rational design, synthesis and in vitro evaluation of allylidene hydrazinecarboximidamide derivatives as BACE-1 inhibitors", Bioorganic & Medicinal Chemistry Letters, Elsevier, 26(1): 33-37. IF: 2.42
  32. Kaushal Y Pathak, Anookh Mohanan, Hemant R Jadhav, Shivani Acharya (2015). "Cardiometabolic risk: Independent role of visceral and liver fat," World Journal of Pharmaceutical Research, 4 (11): 545-558.
  33. Pankaj Wadhwa, Priti Jain, Hemant R. Jadhav (2015). "QSAR and Docking Studies of N-Hydroxy Urea Derivatives as Flap Endonuclease-1 Inhibitors, Current Computer-Aided Drug Design, Bentham Science, 11(4): 346-352. IF: 1.155
  34. Priti Jain, Pankaj Kumar Wadhwa and Hemant R. Jadhav (2015). "Reactive Astrogliosis: Role in Alzheimer's Disease," CNS & Neurological Disorders - Drug Targets, Bentham Science, 14 (7), 872-879, IF: 2.628
  35. Vadiraj D. Kurdekar and Hemant R. Jadhav (2015). "A new open source data analysis python script for QSAR study and its validation," Medicinal Chemistry Research, Bentham Science, 24 (4), 1617-1625. IF: 1.402
  36. Vadiraj D. Kurdekar and Hemant R. Jadhav (2015). "Small Molecular Inhibitors for the Treatment of Rheumatoid Arthritis: Progress so Far," Mini-Reviews in Medicinal Chemistry, Bentham Science, 15, 123-144, IF: 2.628
  37. Vikas Saharan, Kapil Dev, Vandana Kharb, Anupama Singh A, Hemant Jadhav, Suresh Purohit (2014). "Bitterness Score and its Correlation to Drug Concentration: An Approach for Estimating Bitterness Suppression in a Marketed Product of Ofloxacin," Analytical Chemistry Letters, Taylor and Francis, 4 (4), 232-239
  38. Mahaveer Singh and Hemant R. Jadhav (2014). "Melatonin functions and ligands," Drug Discovery Today, Elsevier, 19 (9), 1410-1418, IF: 6.691
  39. Kharb V, Saharan VA, Dev K, Jadhav H, Purohit S. (2014). "Formulation and evaluation of lipid-based taste-masked granules of ondansetron HCl," European Journal of Pharmaceutical Sciences, Elsevier, 62, 180-188, IF: 3.350
  40. Dev K, Kharb V, Singh A, Saharan VA, Jadhav H, Purohit S. (2014). "A proposed methodology for in vitro evaluation of bitterness in drug solutions and in vitro drug release samples," Journal of Pharmaceutical Innovations, Springer, 14 (9), 183-191, IF: 1.00
  41. Kharb V, Saharan VA, Dev K, Jadhav H, Purohit S. (2014). "Formulation, evaluation and 3(2) full factorial design-based optimization of ondansetron hydrochloride incorporated taste masked microspheres", Pharmaceutical Development and Technology, Informa Healthcare, 19 (7): 839–852, IF: 1.202
  42. Priti Jain, Naga Rajiv L, Hemant R Jadhav (2014). "Synthesis and antibacterial profile of cyclized diazonium compounds," Research and Reviews: A Journal of drug design and discovery, 1 (1): 17-20.
  43. Piush Sharma, Ganesh N. Sharma, Birendra Shrivastava, Hemant R. Jadhav (2014). "Evaluation of Antioxidant Potential of Barleria prionitis Leaf and Stem," American Journal of Phytomedicine and Clinical Therapeutics, 2(10), 1177-1186.
  44. Piush Sharma, Ganesh N. Sharma, Birendra Shrivastava, Hemant R. Jadhav (2014). "Phytochemicals Screening, Total Phenol Estimation, Antioxidant Activity of Blainvillea Acmella Leaf and Stem Successive Extracts," Malaysian Journal of Analytical Sciences, 18(2): 351-359.
  45. Priti Jain and Hemant R Jadhav (2013) "Quantitative structure-activity relationship analysis of amino imidazoles as BACE-I inhibitors," Medicinal chemistry research, Springer, 22, 1740-46, IF: 1.402
  46. Mahaveer Singh and Hemant R. Jadhav (2013). "Histamine H3 Receptor Function and Ligands: Recent Developments", Mini-Reviews in Medicinal Chemistry, Bentham Science, 13, 47-57, IF: 2.903
  47. Piush Sharma, B Shrivastava, Ganesh N. Sharma, Hemant R, Jadhav (2013). "Phytochemical and Pharmacological profile of Lanata camara l: An Overview," Journal of Advanced Pharmacy Education & Research, 3 (4), 294-305
  48. P Sharma, B Shrivastava, G Sharma, H Jadhav (2013). "Phytochemical and ethnomedical values of Barleria prionitis L: An overview," Journal of Harmonized Research in Pharmacy, 2, 190-193
  49. Satish N. Dighe and Hemant R. Jadhav (2012). "Microwave-assisted mild, rapid, solventless & Catalyst-Free Chemoselective N-tert-Butyloxycarbonylation of Amines," Tetrahedron Letters, Elsevier, 53, 5803-5806, IF: 2.379
  50. Lavika Jain, Priti Jain, Hemant R. Jadhav (2011). "1-(4-(Phenoxymethyl) benzyl) Piperidine Derivatives as H3 Histaminic Receptor Antagonists: A Quantitative Structure-Activity Relationship study" International Journal of Pharmaceutical Frontier Research, 1, 23-30.
  51. Priti Jain and Hemant R. Jadhav (2011). "Therapeutic Advances in the Treatment of Alzheimer's Disease: Present and Future," Current Drug Therapy, Bentham Science Publishers, 6, 175-185
  52. Dipanwita Pati, Dilip Kumar Pandey, Radhakrishnan Mahesh, Vadiraj Kurdekar and Hemant R. Jadhav (2010). "Anti-Depressant-Like Activity of Mucuna Pruriens; A Traditional Indian Herb in Rodent Models of Depression" Pharmacologyonline, Univ of Salerno, Italy, 1, 537-551, IF: 0.16
  53. Deepti Dongarwar, Inamdar Afeez, M. Dinakaran, Vadiaraj D. Kurdekar and Hemant R. Jadhav (2010). "Synthesis and antioxidant potential of novel 2-isoxazole substituted chromenones synthesized by microwave irradiation". Asian Journal of Research in Chemistry, 3, 1, 106-109
  54. Hemant R. Jadhav and Subodh C. Pal (2005). "Chemistry and Pharmacology of Picrorhiza kurroa Royle Ex. Benth".Pharmacognosy Magazine, Phcog.NET, 1, 140-144
  55. Prashant L. Kole, Hemant R. Jadhav, Prasad. A. Thakurdesai and Anantha N. Nagappa, (2005), "Cosmetics: Potential of herbal extracts," Natural Product Radiance, NISCAIR, 4, 315-321, No. of Citations: 123
  56. R. Jadhav, A. Singh and K. K. Bhutani (2005), "Rationale for immunomodulatory and anti-inflammatory effects of Ocimum sanctum: Radical scavenging potential and effect on nitric oxide production," Acta Horticulturae, Intl. Soc. Hort. Sci., 678, 159-162
  57. Hemant R. Jadhav and K. K. Bhutani (2002), "Antioxidant Properties of Selected Few Herbal Plants," Phytotherapy Research, Wiley, 16, 771-773, IF: 2.068
  58. K. Bhutani and H. R. Jadhav (2001), "Natural Products in Drug Discovery – An Overview of Current Status," Current Research and Information on Pharmaceutical Sciences (CRIPS), NIPER, 2, 2-11.
  59. K. Bhutani and H. R. Jadhav (2000), "R & D in Traditional Medicines," in Course material for International symposium "Preparation and Assessment of Pharmaceutical Registration Dossier" held at NIPER, Mohali.
  60. H. R. Jadhav and K. K. Bhutani (2000), "Regulatory Status of Herbal Medicines – A Global Perspective," in course material for the International Symposium "Preparation and Assessment of Pharmaceutical Registration Dossier" held at NIPER, Mohali.

Book Chapters

  • H. R. Jadhav and K. K. Bhutani (2003), “Regulatory Status of Herbal Medicines – A Global Review”, In: GMP for Botanicals, Edited by Robert Verpoorte and Pulok K. Mukherjee, Business Horizons Ltd, New Delhi.
  • Vandana Kharb, Vikas Anand Saharan, Anupama Singh, Hemant Jadhav, Suresh Purohit (2011), “Bitterness Suppression of Oral Pharmaceuticals” In: The sense of taste”, Edited by Elizabeth J. Lynch and Alexander P. Petrov, Nova Science Publishers Inc. Hauppauge NY, USA.  ISBN: 978-1-61209-748-0.
  • Mahaveer Singh and Hemant R. Jadhav (2017). “Fast Dissolving Oral Films’, book chapter in ‘Current Advances in Drug Delivery Through Fast Dissolving/Disintegrating Dosage Forms’, Edited by Prof. Vikas A Saharan, Bentham Science, pages: 318-356. ISBN: 978-1-68108-460-2.

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