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Dr. Shambojit Roy

Assistant Professor
Department of Chemical Engineering

Biochemical / Bioprocess Engineering, Cancer therapeutics, Cell Imaging, Drug delivery, nano materials
Birla Institute of Technology & Science, Pilani
Hyderabad Campus, office: J123
Jawahar Nagar, Kapra Mandal
Dist.-Medchal-500 078
Telangana, India

List of publications

Journal Publications

  1. Roy, S., Qian, G., Zhang, H., Chen, Z., Provenzano, P. Migration and cytotoxicity of engineered T cells through the dense stroma of 3D pancreatic tumor spheroids. (Under preparation).
  2. Roy, S., Curry, S. D., Bagot, C. C., Mueller, E. V., Mansouri, A. M., Park, W., Cha, J. N., & Goodwin, A. P. (2022). Enzyme Prodrug Therapy with Photocrosslinkable anti EGFR Affibodies Conjugated to Upconverting Nanoparticles. ACS Nano, 16(10), 15873-15883. [https://doi.org/10.1021/acsnano.2c02558]
  3. Roy, S., Curry, S., Bibbey, M. G., Chapnick, D., Liu, X., Goodwin, A. P., & Cha, J. N. (2022). Effect of covalent photo-conjugation of affibodies to Epidermal Growth Factor Receptor (EGFR) on cellular quiescence. Biotechnology and Bioengineering, 119(1), 187-198. [https://doi.org/10.1002/bit.27964]
  4. Ganguly, S., Roy, S., Goodwin, A. P., & Cha, J. N. (2021). Generation of 3D cellular spheroids using DNA modified cell receptors and programmable DNA interactions. Biomaterials Science, 9(23), 7911-7920. [http://10.1039/D1BM01193F]
  5. Harris, A. W., Roy, S., Ganguly, S., Parameswar, A. V, Lucas, F. W. S., Holewinski, A., Goodwin, A. P., Cha, J. N. (2021). Investigating the use of conducting oligomers and redox molecules in CdS – MoFeP biohybrids. Nanoscale Advances, 3, 1392–1396. [10.1039/D0NA00678E]
  6. Roy, S., Cha, J. N., & Goodwin, A. P. (2020). Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review. Bioconjugate Chemistry, 31(11), 2465–2475. [https://doi.org/10.1021/acs.bioconjchem.0c00529]
  7. Harris, A. W., Harguindey, A., Patalano, R. E., Roy, S., Yehezkeli, O., Goodwin, A. P., & Cha, J. N. (2020). Investigating Protein-Nanocrystal Interactions for Photodriven Activity. ACS Applied Bio Materials. 3(2), 1026-1035. [https://doi.org/10.1021/acsabm.9b01025]
  8. Roy, S., Brasino, M., Harguindey, A., Chapnick, D. A., Liu, X., Cha, J. N., Goodwin, A. P. (2020) Enzymes Photo-Cross-Linked to Live Cell Receptors Retain Activity and EGFR Inhibition after Both Internalization and Recycling. Bioconjugate Chemistry, 31(1), 104-112. [https://doi.org/10.1021/acs.bioconjchem.9b00781]
  9. Harguindey, A., Roy, S., Harris, A. W., Fairbanks B. D., Goodwin, A. P., Bowman, C. N., & Cha, J. N. (2019). Click Nucleic Acid Mediated Loading of Prodrug Activating Enzymes in PEG-PLGA Nanoparticles for Combination Chemotherapy. Biomacromolecules, 20(4), 1683-1690. [https://doi.org/10.1021/acs.biomac.9b00040]
  10. Bull, D. S., Kienle D. F., Chaparro Sosa, A. F., Nelson, N., Roy, S., Schwartz, D. K., Kaar, J. L., & Goodwin, A. P. (2019). Surface-Templated Nanobubbles Protect Proteins from Surface-Mediated Denaturation. The Journal of Physical Chemistry Letters. 10(11), 2641–2647. [https://doi.org/10.1021/acs.jpclett.9b00806]
  11. Brasino, M., Roy, S., Erbse, A. H., He, L., Mao, C., Park, W., Cha, J. N., Goodwin, A. P. (2018). Anti-EGFR Affibodies with Site-Specific Photo-Cross-Linker Incorporation Show Both Directed Target-Specific Photo-conjugation and Increased Retention in Tumors. Journal of the American Chemical Society (JACS), 140(37), 11820–11828. [https://doi.org/10.1021/jacs.8b07601]
  12. Yildirim, A., Shi, D., Roy, S., Blum, N. T., Chattaraj, R., Cha, J. N., & Goodwin, A. P. (2018). Nanoparticle-Mediated Acoustic Cavitation Enables High Intensity Focused Ultrasound Ablation Without Tissue Heating. ACS Applied Materials and Interfaces, 10(43), 36786-36795. [https://doi.org/10.1021/acsami.8b15368]