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Soumitra Ghosh

Assistant Professor, Department of Biological Sciences,
BITS Pilani, Pilani Campus

Cancer Biology
Department of Biological Sciences, Pilani Campus
Birla Institute of Technology & Science, Pilani- 333031, Rajasthan. India.
Soumitra-Ghosh

Publications

 

As lead author:                                                                                                                                                                                                                   (*Contributed equally)

1. Ghosh S, Isma J, Mazzeo L, Toniolo A, Ostano P, Das M, Simon C, Dotto G. P, Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation (In revision Nature Communications). 

2. Ma M*, Ghosh S*, Tavernari D, Katarkar A, Clocchiatti A, Mazzeo L, Samarkina A, Epiney J, YuYi-Ru, Ho PC, Levesque M, Özdemir BC, Ciriello G, Dummer R, & Dotto GP. Sustained AndrogenReceptor signaling is a determinant of melanoma cell growth potential and tumorigenesis. Journalof Experimental Medicine, 2021, 218: e20201137.

3. Clocchiatti A*, Ghosh S*, Procopio MG, Mazzeo L, Bordignon P, Ostano P, Goruppi S, Bottoni G,Katarkar A, Levesque M, Kölblinger P, Dummer R, Neel V, Berna C. Özdemir BC & Dotto GP.Androgen receptor functions as a transcriptional repressor of Cancer Associated Fibroblast (CAF)activation. Journal of Clinical Investigations, 2018, 128: 5531-5548.

4. Kim DE*, Procopio MG*, Ghosh S*, Jo SH, Goruppi S, Magliozzi F, Bordignon P, NeelV, Angelino P, & Dotto GP. Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation. Journal of Experimental Medicine, 2017, 214: 2349-2368.

5. Ghosh S, Padmanabhan B, Anand C & Nagaraja V. Lysine acetylation of the Mycobacterium tuberculosis HU protein modulates its DNA binding and genome organization. Molecular Microbiology, 2016, 100: 577-588. Ghosh S, Padmanabhan B, Godbole AA, Tare P, Ahmed W, Vasu K, China A, Kumar R, Mitra A & Nagaraja V. Transcriptional regulation of topology modulators and transcription regulators of Mycobacterium tuberculosis. Biochem Biophys Res Commun., 2016, 475:257-263.

6. Ghosh S, Padmanabhan B, Godbole AA, Tare P, Ahmed W, Vasu K, China A, Kumar R, Mitra A & Nagaraja V. Transcriptional regulation of topology modulators and transcription regulators of Mycobacterium tuberculosis. Biochem Biophys Res Commun., 2016, 475:257-263.

7. Bhowmick T*, Ghosh S*, Dixit K, Ganesan V, Ramagopal UA, Dey D, Sarma SP, Ramakumar S& Nagaraja V. Targeting Mycobacterium tuberculosis nucleoid-associated protein HU withstructure-based inhibitors. Nature Communications, 2014, 5, 4124.

8. Ghosh S, Mallick B & Nagaraja V. Direct control of mycobacterial topoisomerase I activity by anucleoid-associated protein. Nucleic Acids Research, 2014, 42:11156-11165.

9. Ghosh S, Indi SS & Nagaraja V. Regulation of lipid biosynthesis, sliding motility and biofilmformation by a membrane-anchored nucleoid-associated protein of Mycobacterium tuberculosis. Journal of Bacteriology. 2013, 195: 1769-1778. 

 

As Co author 

10. Mazzeo L , Ghosh S , Di Cicco E , Isma J , Tavernari D , Samarkina A, Ostano P, Youssef MK, Simon C & Dotto GP, ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation, bridging loss of the androgen receptor to AP-1 activation. Nature Communications, 2024, 15:1038.

11. Samarkina A, Youssef MK, Ostano P, Ghosh S, Ma M, Tassone B, Proust T, Chiorino G, Levesque M. P, Goruppi S, Dotto GP, Androgen Receptor is a Determinant of Melanoma targeted drug resistance. Nature Communications, 2023; 14: 6498.

12. Bottoni G*, Katarkar A*, Tassone B, Ghosh S, Clocchiatti A, Goruppi S, Bordignon P, Jafari P, Tordini F, Lunardi T, Hoetzenecker W, Neel V, Lingner J & Dotto GP. CSL controls telomere maintenance and genome stability in human dermal fibroblasts. Nature Communications, 2019, 10, 3884.

13. Datta C, Jha RK, Ahmed W, Ganguly S, Ghosh S, Nagaraja V. Physical and functional interactionbetween nucleoid-associated proteins HU and Lsr2 of Mycobacterium tuberculosis: altered DNAbinding and gene regulation. Molecular Microbiology, 2019, 111: 981–994.

14. Anand C, Garg R, Ghosh S, & Nagaraja V. A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis. Biochem Biophys Res Commun, 2017, 493:1204-1209.

15. Gupta M, Sajid A, Sharma K, Ghosh S, Arora G, Singh R, Nagaraja V, Tandon V & Singh Y. HupB, a nucleoid-associated protein of Mycobacterium tuberculosis, is modified by serine/threonine protein kinases in vivo. Journal of Bacteriology, 2014, 196: 2646-2657.

16. Sengupta S, Ghosh S & Nagaraja V. Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme. Microbiology. 2008, 154: 2796-2803. 

17. Saravanan M, Vasu K, Ghosh S & Nagaraja V. Dual role for Zn2+in maintaining structural integrity and inducing DNA sequence specificity in a promiscuous endonuclease. Journal of Biological Chemistry, 2007, 282: 32320-32326.

18. Suryanarayanarao R, Bhowmick T, Ghosh S, Udupi R A & Nagaraja V. Crystal structure and structure-based drug design of HU (histone-like protein) from M. tuberculosis, Acta Cryst. 2008, A64, C342.