Employer | Job title | Start date | End date | Duties/Responsibilities |
BITS Pilani, Pilani Campus | Assistant Professor | Aug 2018 | Current | In-charge of CADD facility, Practice School, development of drug metabolism and toxicity prediction models. |
SPP SPTM, SVKM’s NMIMS, Mumbai | Associate Professor | Feb 2018 | Aug 2018 | Develop drug metabolism prediction models using quantum chemistry and PKPD modeling. |
SPTM, SVKM’s NMIMS, Shirpur campus | Associate Professor | March 2016 | Jan 2018 | Setup computational and synthesis research facility, project submission to DST, CSIR and teaching. |
Qualichem Laboratories | Sr. Chemist | Oct. 2015 | Feb 2016 | In-charge of instrument section for LC-MS/MS, GC-MS, HPLC-UV and spectrophotometry. |
AstraZeneca, Macclesfield, UK | Postdoc | June 2013 | June 2015 | The design/synthesis of novel heterocycles. |
Indian Institute of Science (IISc, Bangalore), INDIA | Postdoc | Dec. 2012 | May 2013 | Perform P450 modeling research work modeling support to other projects in the lab. |
Gurunanak College of Pharmacy, Nari, Nagpur, Maharashtra, INDIA | Assistant Professor | July 2012 | Dec 2012 | Guiding M. Pharm. students for thesis work and teaching Pharm. Chemistry to B. Pharm. students. |
Lecturer | Aug 2006 | June 2007 | Teaching Pharmaceutical Chemistry (organic and analytical), conducting practical sessions. |
Education:
Qualification | Year | Institute | Percentage/CGPA |
Ph. D. in Medicinal Chemistry | 2012 | NIPER, S.A.S. Nagar, India | 9.33/10 |
M. S. (Pharm) in Medicinal Chemistry | 2006 | NIPER, S.A.S. Nagar, India | 9.16/10 |
Graduate Aptitude Test in Engineering (GATE), Pharmaceutical Sciences | 2004 | Conducted by IIT, Delhi, Inida | 94.57 |
B. Pharm. | 2004 | Department of Pharmaceutical Sciences Nagpur University | 71.36 |
Previous funds and awards
1) European Molecular Biology Organization (EMBO) short-term fellowship 2017: €3,957 fellowship+ €600 (travel grant). 2) University seed grant, SVKM’s NMIMS Deemed-to-be-University by UGC act. Rs. 1,00,000/-. 3) Industrial Postdoctoral Fellowship by AstraZeneca, UK. 4) Dr. DS Kothari Postdoctoral fellowship by University Grants Commission (UGC), New Delhi, India
Current grant income
Rs. 2,00,000/- per year under research initiation grant (RIG), Birla Institute of Technology and Science, Pilani (BITS Pilani), Pilani, Rajasthan 333031, India.
Publications
1. Dixit, V.A., Lal, L. A.; Agrawal, S. R. Recent advances in the prediction of non-CYP450-mediated drug metabolism. WIREs Comp. Mol. Sci. 2017, doi: 10.1002/wcms.1323.
2. Dixit, V. A.; Goundry, W. R. F., Tomasi, S. C=C/B-N isoelectronic substitution in five membered heterocycles. A computational study. New. J. Chem. 2017, doi: 10.1039/C7NJ00950J.
3. Joshi, D.; Mittal, D. K.; Shukla, S.; Srivastav, S. K.; Dixit, V. A. Curcuma longa Linn. extract and curcumin protect CYP 2E1 enzymatic activity against mercuric chloride-induced hepatotoxicity and oxidative stress: A protective approach. Exp. and Toxicol. Pathol. 2017 doi: 10.1016/j.etp.2017.02.009.
4. Joshi, D.; Srivastav, S. K.; Belemkar, S.; Dixit, V. A. Zingiber officinale and 6-gingerol alleviate liver and kidney dysfunctions and oxidative stress induced by mercuric chloride in male rats: A protective approach. Biomed. Pharmacother. 2017, 91, 645-655.
5. Dixit, V.A.; Deshpande, S.S. Advances in computational prediction of regioselective and isoform specific drug metabolism catalyzed by de CYP450s. ChemistrySelect 2016, 1, 6571-6597.
6. Dixit, V. A.; Rathi, P. C., Gohlke, H., Petersen, R. K., Kristiansen, K., Chakraborti, A. K., Bharatam, P. V. Design and synthesis of novel Y-shaped barbituric acid derivatives as PPARγ activators. Eur. J. Med. Chem. 2016, 108, 423-435.
7. Dixit, V. A.; Bhatia, S.; Jangra, H.; Bharatam, P. V. Formation/Fate of Reactive Metabolites from General Anesthetics and A Comparison of Toxic and Non-Toxic Analogues: A DFT Study. Drug Metab. Lett. 2012, 6, 221-234.
8. Taxak, N.; Dixit, V. A.; Bharatam, P. V. Density Functional Study on the Cytochrome Mediated S-Oxidation: Identification of Crucial Reactive Intermediate on the Metabolic Path of Thiazolidinediones. J. Phys. Chem. A. 2012, 116, 10441–10450.
9. Dixit, V. A.; Bharatam, P. V. Toxic metabolite formation from Troglitazone (TGZ): New Insights from DFT study. Chem. Res. Toxicol. 2011, 24, 1113-1122.
10. Malik, S.; Dixit, V. A.; Bharatam, P. V.; Kartha, K. P. R. A simple, mild, and regioselective method for the benzylation of carbohydrate derivatives promoted by silver carbonate. Carbohydr. Res. 2010, 345, 559-564.
11. Chimni, S. S.; Bala, N.; Dixit, V. A.; Bharatam, P. V. Thiourea catalyzed aminolysis of epoxides under solvent free conditions. Electronic control of regioselective ring opening. Tetrahedron 2010, 66, 3042-3049.
12. Dixit, V. A.; Rathi, P. C.; Bharatam, P. V. Intramolecular dihydrogen bond: A new perspective in Lewis acid catalyzed nucleophilic epoxide ring opening reaction. J. Mol. Struct.: Theochem 2010, 962, 97-100.
13. Dixit, V. A.; Bharatam, P. V. SAR and Computer-Aided Drug Design (CADD) approaches in the discovery of Peroxisome Proliferator-Activated Receptor γ (PPARγ) activators: A perspective. J. Compt. Med. 2013, Article ID 406049.