The VIbrio and STructural Analysis Lab (VISTA):
The Vista lab, at present has two main areas of research. The first involves the lifestyle switching of Vibrio cholerae and induction of virulence. Present research in this area involves investigation into a GGEEF domain protein from V. cholerae and characterization of a primary sigma factor from the same source. While structural studies involving X-ray crystallography is a major tool for these studies, molecular biology of V. cholerae and other biophysical methods are also being dealt with.
The second area is concerned with the prediction and validation of oncogenicity of microRNAs. While experimental methods to determine the involvement of microRNAs in oncogenic pathways is a time-consuming and extensive process, this lab has struck upon an innovative tool to predict and validate oncomeric microRNAs.
Additionally, the lab also deals with independent crystallization experiments from various natural sources, like Naja kaouthia (Indian monocellate cobra) and Moringa oleifera. The study of extremophilic protein architecture and stress adaptations are also some of the nascent areas the lab is interested in.